Broad Institute
@broadinstitute
Followers
97,351
Following
3,751
Media
2,265
Statuses
15,134
A unique, collaborative community pioneering a new model of biomedical science
Cambridge, MA, USA
Joined April 2009
Don't wanna be here?
Send us removal request.
Explore trending content on Musk Viewer
Champions
• 232355 Tweets
Dortmund
• 192101 Tweets
Senna
• 176180 Tweets
Sancho
• 137284 Tweets
Gustavo Petro
• 131829 Tweets
Mbappé
• 90312 Tweets
#BVBPSG
• 82604 Tweets
Madonna
• 81354 Tweets
Boulos
• 57813 Tweets
Paco Villa
• 56601 Tweets
Powell
• 48440 Tweets
Le PSG
• 39308 Tweets
Ramos
• 33114 Tweets
Flopou
• 32908 Tweets
Dembele
• 31432 Tweets
Bruno Mars
• 28154 Tweets
Canelo
• 20971 Tweets
باريس
• 20834 Tweets
Kolo Muani
• 20338 Tweets
دورتموند
• 16970 Tweets
Adeyemi
• 16054 Tweets
Fullkrug
• 14979 Tweets
Reus
• 14709 Tweets
Fabian Ruiz
• 14388 Tweets
Nuno Mendes
• 14137 Tweets
Ronnie
• 13707 Tweets
Hakimi
• 12777 Tweets
Luis Enrique
• 10802 Tweets
Maatsen
• 10155 Tweets
Barcola
• 10053 Tweets
Congratulations to
@eric_lander
who will become Presidential Science Advisor to
@JoeBiden
! As Eric transitions to this new role, we welcome Broad’s Chief Scientific Officer Todd Golub as Director of the Broad Institute. Learn more:
12
154
771
Eli Broad was one of the great philanthropists of our time, and his impact on biomedicine is immeasurable. His extraordinary vision and support launched the Broad Institute, and leaves behind formidable legacies in education, art, and beyond.
5
104
499
We are thrilled to announce the launch of the Eric and Wendy
#SchmidtCenter
. Merging biology and machine learning to understand the programs of life, the Center will enable a new field of interdisciplinary research aimed at improving human health.
5
118
465
Congratulations to Aviv Regev, who moves on to an amazing opportunity with
@Genentech
in August. She was the first faculty member hired at Broad and is a remarkable scientific leader and mentor. Thanks, Aviv!
4
83
457
Researchers have developed a new way to deliver molecular therapies to cells. The system, called SEND, can be programmed to encapsulate and deliver different RNA cargoes. Learn more:
5
107
438
Prime editing, a new
#CRISPR
#genomeediting
tool created by
@davidrliu
/
@liugroup
, directly edits human cells in a precise, efficient, and highly versatile fashion. The tool has the potential to correct up to 89% of
#genetic
defects.
8
236
435
Today we recognize, thank, and celebrate the women in our Broad community – and worldwide! We need more
#WomenInScience
, more women scientists from all backgrounds, and more young girls choosing STEM careers!
#InternationalDayOfWomenInScience
#WomenAndGirlsInScience
3
120
406
Cost of sequencing the first human genome was $3 billion. Today it costs $600 dollars.
#BroadAt15
#HumanGenome
6
196
400
A new class of base editor, developed in a collaboration between
@davidrliu
, Joseph Mougous
@UW
,
@VamsiMootha
, and colleagues, enables precision editing of mitochondrial DNA (mtDNA). Read more:
3
129
361
Slide-seq technique generates high-resolution maps of cellular relationships in tissues, without the need for a microscope
5
136
320
A new method called Slide-tags lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds upon Slide-seq, both developed by the labs of
@insitubiology
&
@macosko
.
2
56
293
In a matter of days, the
@BroadGenomics
Platform converted its clinical processing lab to a
#COVID19
testing facility capable of testing 2,000 samples a day.
Read how the platform worked to modify protocols, train staff members, and reshape lab spaces:
6
104
285
Today
@BroadGenomics
processed their 500,000th
#COVID19
test! In partnership with
@MassDPH
,
@CambMA
, hospitals, nursing homes, and low-income housing, the lab is working ‘round the clock. Thank you to everyone who is a part of this fantastic team!
7
78
284
Broad Institute is working closely with
@MassGeneralNews
,
@BrighamWomens
, and other area hospitals to put our high-throughput genomic capabilities at the disposal of
@MassGov
to enable increased capacity for
#COVID19
diagnostic testing. Learn more:
3
90
233
Today
@BroadGenomics
processed its 10 millionth
#COVID19
test! In the US, about 1 in every 20 tests performed daily are processed at the Broad. Thank you to all of our Broadies for their hard work, innovation, & dedication, especially to the 500+ Broadies working 24/7 onsite!
3
66
226
Broad set to sequence its 100K whole human genome on
#DNADay18
; milestone to be crossed on 15th anniversary of completion of
#HumanGenomeProject
3
66
199
Researchers from Broad and
@DanaFarber
scanned thousands of drugs in hundreds of cell lines and found that dozens of non-oncology drugs can unexpectedly kill
#cancer
cells
4
115
199
The first ever study to sequence single cells infected with a BSL-4 level pathogen has revealed new details of how the
#Ebola
virus alters the host immune response for its own benefit during infection.
@PardisSabeti
@dkotliar
@Aaron_E_Lin
@sabeti_lab
3
53
195
A single-cell atlas of the colon, generated from hundreds of thousands of cells, offers new clues into what goes wrong in ulcerative colitis and why some patients don’t respond to drugs. Check out the paper in
@CellCellPress
:
1
72
185
After nearly five years of work from researchers including
@amitvkhera
, a Broad discovery — polygenic scoring for genetic risk assessment for a common disease — has found its way into the clinic...an important step for genomic medicine.
4
53
182
Broad researchers led by
@davidrliu
/
@liugroup
have developed a new
#CRISPR
genome-editing approach, with a wide range of versatility in human cells, by combining two of the most famous proteins in molecular biology into a single machine.
2
86
180
Ben Neale, senior co-author of the
@Sciencemagazine
paper “Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior,” provides perspective on the scientific findings:
“What did this study find?” (1/6)
3
86
173
Broad recently launched the Gene Regulation Observatory to build thorough map of the non-coding genome, elucidate disease risk factors and roots of cell diversity, and inform cellular engineering. Learn more about
#BroadGRO
:
3
30
174
With 12 industry and non-profit partners, Broad has launched a cell imaging consortium, led by
@DrAnneCarpenter
, to fuel efforts for discovering and developing new therapeutics. Read more about creating the largest collection of
#CellPainting
cell images:
1
42
169
It's International Day of Women and Girls in Science! Today (and every day) we celebrate and thank the many inspiring and innovative
#WomeninScience
in the Broad community and beyond!
2
56
169
Science (
@sciencemagazine
) recognizes single-cell RNA-seq, and its potential for spurring advances in basic research and medicine, as the 2018 Breakthrough of the Year!
@humancellatlas
0
66
167
Researchers have developed a new version of prime editing that can install or swap out gene-sized DNA sequences in human cells — and could be a safer approach to gene therapy.
2
52
157
Researchers at the Broad Institute have developed a new, efficient, and scalable microscopy system for creating maps of cells, using chemical reactions to encode spatial information. Read more here and in
@CellCellPress
:
3
80
154
The Broad Institute stands with Ukraine during these attacks on the country’s freedom and democracy. We support the Ukrainian community, locally and across the world, and hope for peace.
1
15
157
#Scientists
: Need help writing papers or grants, making posters, preparing for a talk, or assembling your CV? Check out the CommKit:
0
105
154
In a new Broad video,
@NIHDirector
, Jonathan Brown (
@VUMChealth
), and
@davidrliu
describe the impact of their recent work on treating
#progeria
in an animal model -- a story that began thirty-six years ago. Watch:
0
39
149
Data set of half a million human immune cells openly accessible on preview site that provides initial access to
@humancellatlas
data:
0
105
149
“Every cell is an experiment now.” In
@techreview
, Aviv Regev talks about single-cell genomics and the
@humancellatlas
’s efforts to map each of the human body’s biological building blocks.
1
77
149
An international effort called Zoonomia Project has released the largest dataset of mammalian genomes, aimed at advancing both human health research and biodiversity conservation, also revealed species at risk of extinction.
2
55
147
A research team including
@LukeKoblan
, Mike Erdos (
@NIH
), Leslie Gordon (
@Progeria
), Jonathan Brown (
@VanderbiltU
),
@NIHDirector
, and
@davidrliu
significantly extended the lives of mice with
#progeria
using base editing, with "stunning" results.
0
41
149
In
@CellCellPress
, researchers used single-cell RNA sequencing to define four states of glioblastoma cells and showed that the cells can flip between states, shedding light on why the brain cancer is so hard to treat.
1
57
146
Prime editing can correct most known disease-causing mutations, and now has a new vehicle to deliver its machinery in mice. The
@davidrliu
lab has engineered virus-like particles that deliver prime editors efficiently enough to have a therapeutic benefit.
2
40
148
Another use for
#CRISPR
: not as a tool for cutting DNA, but for capturing the proteins controlling a given gene's transcription.
2
100
143
For 8 years, the
#gnomAD
Consortium has been working to compile and study a collection of >125,000 human exomes & 15,000 genomes. Today, they've revealed their first set of discoveries in a set of 7
@nature
,
@NatureComms
&
@NatureMedicine
papers.
1
70
144
Today,
@BroadGenomics
sequenced its 100,000th whole human genome! The full recording of our event marking the milestone is now available on Facebook. Happy
#DNADay18
!
3
49
141
“We want images to become as computable as the genome.”
@DrAnneCarpenter
and her lab are using computer vision and machine learning to turn microscope images of cells into rich sources of data that can be systematically analyzed.
1
47
140
Feng Zhang on gene-edited embryo work: "Not only do I see this as risky, but I am also deeply concerned about the lack of transparency surrounding this trial."
2
71
138
A new mathematical model picks out cancer “driver” mutations from less important “passenger” ones more accurately than previous models. It analyzed genomic “hotspots”, where
#cancer
mutations tend to recur, using sequencing data from about 10,000 patients.
3
63
137
Our community values equality, respect, and understanding. We stand with the Black community, and commit to facilitating these necessary, open and honest conversations. Racism and hate have no place at Broad, in science, or anywhere. We are listening and learning.
2
33
136
Two scientists are urging the scientific community to create a more comprehensive map of
#cancer
’s genetic dependencies. They are calling on institutions & researchers to probe all 20,000 genes & test 10,000 drugs & drug candidates in 20,000 cancer models.
5
36
133
65+ centers and studies have signed on to be part of the COVID-19 Host Genetics Initiative and answer the question: Why do some people have worse
#COVID19
symptoms than others?
@dalygene
talks about the initiative's origin stories and goals.
#coronavirus
2
61
133
Researchers post genetic profiles of half a million human immune cells on
@humancellatlas
online portal
0
87
127
Congratulations to Gad Getz, Aviv Regev, and Chuan He, winners of the 2017 Paul Marks Prize for Cancer Research:
4
36
129
.
@davidrliu
/
@liugroup
has improved prime editing, which can make a wide range of genome edits. The new version can work in cells & tissues that have been difficult to edit and could potentially be easier to deliver to cells in the body as new treatments.
0
29
127
Today we announce
@EricSchmidt
as the next Chair of the Broad Institute Board of Directors, succeeding Louis V. Gerstner, Jr. Learn more:
9
22
128
Ribosomes are molecular machines in the cell that make proteins. Researchers have come up with a high-throughput method for building ribosomes using parts from different microbes and that measures and optimizes ribosome function.
1
29
120
Broad launches the Gene Regulation Observatory (
#BroadGRO
) to build thorough map of the non-coding genome, elucidate disease risk factors and roots of cell diversity, and inform cellular engineering.
0
38
120
Congratulations to Feng Zhang, Ben Ebert, Beth Stevens, and Ed Boyden on being named Howard Hughes Medical Institute (HHMI) investigators!
0
26
119
#SlideSeq
uses sequencing to build detailed tissue maps without need for a microscope; shows numerous cell types and patterns of gene expression
1
39
120
“Prime editing,” a new
#CRISPR
genome-editing tool, created by
@davidrliu
/
@liugroup
combines two key proteins and a new
#RNA
to make targeted insertions, deletions, and all possible single-letter changes in the
#DNA
of human cells. Learn how it works:
1
60
117
1,300+ scientists and clinicians analyzed 2,600+ whole genomes of 38 different tumor types over the last six years, completing the most comprehensive study of whole
#cancer
genomes to date and significantly improving our understanding of cancer.
2
45
116
Curious what Broad’s
#COVID19
testing process looks like? Come, take a video tour of the Broad’s COVID-19 testing lab with scientists who will explain a novel automation system for test processing that is scalable, modular, and high-throughput.
35
45
114
Congratulations to
@PardisSabeti
for being named as one of BBC's 100 inspiring and influential women from around the world for 2020!
#BBC100Women
5
14
114
The nervous and immune systems have long been thought to be separate entities, but new research from
@shaleklab
has uncovered a direct cellular interaction between the two: Pain-sensing neurons that surround lymph nodes in mice and modulate their activity.
2
31
114
The
@BroadGenomics
team has completed over 30,000
#COVID19
tests to date! Today, a public portal was launched displaying real-time testing stats.
1
43
116
Researchers have developed a way to get
#GeneEditing
proteins inside cells in animal models with high enough efficiency to show therapeutic benefit.
1
32
113
A team at Broad and
@stjuderesearch
used base editing to convert the mutation underlying sickle cell disease to a benign variant in an animal model — enabling long-lasting, healthy blood cell production. Read more about this
@nature
paper:
7
30
114
We’re excited to introduce
#HCRFlowFISH
, a new method for characterizing the function of gene regulatory elements developed by
@ReillyLikesIt
,
@r_tewhey
,
@SagerGosai
,
@PardisSabeti
and colleagues. Now in
@naturegenet
; some highlights below. 1/6
2
43
108
A group of gut bacteria can metabolize enough cholesterol to potentially affect people’s metabolism. This discovery suggests a possible reason why some people can consume more cholesterol in their diet with minimal effect on their blood cholesterol levels.
2
42
110
Sheila Dodge of
@BroadGenomics
shares how she and her collaborators are gearing up to run more than 1,000
#COVID19
tests a day.
4
40
109
In
@CellCellPress
, researchers describe a single-cell map of the enteric nervous system and its connections to the intestinal, immune, and central nervous systems -- as well as links to disorders of the gut and diseases affecting the brain. Learn more:
0
46
105
Newly discovered class of molecules may boost
#cancer
vaccine development. A team led by
@VanAllenLab
demonstrates the presence of an entirely new class of
#neoantigens
in this new study published in
@NatureBiotech
.
1
60
108
Scientists have developed a suite of molecular tools that increase the efficiency of prime editing, a gene editing method with the potential to correct the vast majority of known disease-causing genetic mutations.
1
34
106
We are thrilled to announce Fei Chen as Broad's newest core institute member. Fei will also be joining
@HSCRB
as an assistant professor. Congratulations, Fei!
2
9
106
Big milestone today for the
#NeuroGAP
-P study! The largest genetics study on
#psychosis
in Africa recruited its 10,000th participant today. Moi Uni PI
@LukoyeAtwoli
says he never expected we would have this success so early.
@StanleyCenter
(1/2)
4
52
102
The Broad Institute Clinical Research Sequencing Platform, in partnership with
@MassGov
,
@MassDPH
, and area hospitals, has begun processing
#COVID19
patient test samples. The CLIA-certified lab now has capacity to process ~2,000 tests per day.
#coronavirus
0
26
103
A new study of whole genomes from more than 250,000 people reveals new complexity in how the nuclear and mitochondrial genomes interact.
2
34
104
Through
@count_me_in
's patient-partnered research approach, Broad and
@DanaFarber
researchers, led by
@corrie_painter
and
@Nikhilwagle
, have conducted the largest study of
#angiosarcoma
, revealing new mutations and therapeutic possibilities.
@ASCaProject
2
41
100
Researchers at Broad,
@VanderbiltU
,
@NIH
, and other institutions have used base editing in mice to treat progeria, a progressive and fatal genetic condition. The work, published in
@Nature
, provides a blueprint for addressing other genetic disorders.
2
29
99
15 years ago today, MIT, Harvard, Beth Israel Deaconess Medical Center, Boston Children’s Hospital, Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Massachusetts General Hospital came together to launch the Broad Institute. (2/3)
#BroadAt15
3
28
100
Most
#scRNAseq
methods lose spatial info (cell location within tissue, interactions with neighbors).
@broadinstitute
&
@KTHresearch
scientists teamed up to develop HDST, which captures spatial info & helps researchers see a tissue's architecture as never before.
2
43
99
Researchers combine population genetics with electronic health records from Finland to get insights into rare diseases. Read more in this Q & A with Alicia Martin, a postdoc in the
@dalygene
lab.
3
44
94
Congratulations to
@BroadGenomics
for reaching another big milestone – over 300K
#COVID19
tests processed in partnership with
@MassDPH
,
@CambMA
, hospitals, nursing homes, low-income housing, and more. Take a behind the scenes look at our team at work:
2
30
97
Congratulations
@AnnaGreka
on the fantastic
@TEDTalks
! Hear from Anna on "The world's rarest diseases — and how they impact everyone."
@GrekaLab
13
26
95
The Precision Cardiology Lab of
@broadinstitute
and
@BayerPharma
has created the most comprehensive cellular map to date of the human heart. The team uncovered new cell types and gene expression patterns that could be key to treating heart disease someday.
1
29
95
A new class of base editor, developed in a collaboration between
@davidrliu
, Joseph Mougous
@UW
,
@VamsiMootha
, and colleagues, enables precision editing of mitochondrial DNA (mtDNA). Read more:
2
29
95
Five Broad researchers —
@BalskusLab
,
@redmakeda
, Sun Hur,
@CKadoch
, and
@KajimuraLab
— are among the 33 biomedical researchers nationwide who will become
@HHMINEWS
investigators this fall. Congratulations to all!
2
11
97
Fei Chen began his career studying electrical engineering, then an experiment with
#DNA
inspired him to apply his expertise to
#biomedical
research. Since then, Chen has invented two innovative microscopy techniques, and he’s pursuing even more bold ideas:
1
37
95
Can we cure genetic diseases by rewriting DNA? David Liu shared his story of scientific discovery at
@TEDTalks
1
48
92
#CRISPR
-based diagnostic platform SHERLOCK adapted to work as a miniature paper test, allowing rapid and simple detection in any setting
1
68
92
Broad and
@sangerinstitute
scientists have validated the two largest
#CRISPR
-Cas9 genetic screens in 725 cancer models across 25 different cancer types. The large dataset will help speed up the discovery and development of new
#cancer
drugs.
@CancerDepMap
0
41
88
New research published in
@NatureCancer
from Broad and
@DanaFarber
found drugs for diabetes, inflammation, alcoholism — and even for treating arthritis in dogs — can also kill cancer cells in the lab.
1
40
89
"Biology needs more staff scientists" --
@nature
commentary from
@StanleyCenter
director Steven Hyman
1
79
90
Today the Zhang Lab is openly sharing a research protocol to support future development of potential diagnostics. Here’s a timelapse of the SHERLOCK system being used to detect synthetic COVID-19 samples in a lab setting. Learn more:
0
34
90
A new PACE-based system generates protein degradation tags that interact with an otherwise-inert small molecule to trigger the rapid breakdown of a cell’s native proteins, with molecular glue systems that can become useful new research tools.
0
23
87
.
@BroadGenomics
has now sequenced over 300,000 whole human genomes! The genomic data available from 2003 to now has been transformative to medical and health research. Congratulations to the Broad Genomics team on this big milestone!
Broad Genomics recently sequenced whole human genome number 300,000. We are now producing genomes at a pace of 3-5k every week.
#genomics
6
28
278
1
21
86
Broad undergrad researcher Esther Elonga has gone from refugee in Uganda to
@Harvard
student and will soon start a
@Stanford
MD/PhD program. In a
#WhyIScience
Q&A, she talks about why she wants to become a physician-scientist and advocate for refugees.
2
12
85
In
@CellCellPress
, researchers detail a single-cell map of the enteric nervous system and its connection to the intestinal, immune, and central nervous systems -- as well as the links to disorders of the gut and diseases affecting the brain. Learn more:
0
17
81