Bruce Levine, Ph.D. 🇺🇦
@BLLPHD
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12,940
Professor @Pennmedicine #CellTherapy #Genetherapy #Inventor #Kymriah #CARTCell @TmunityTx & @CapstanTx CoFounder, Past President @ISCTGlobal , @PNASNexus AE
Philadelphia, PA
Joined November 2010
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This picture is worth a thousand words! 🙏
Emily Whitehead 10 years on and celebrating a cure
#CARTCell
#tcellrx
#immunotherapy
#celltherapy
#genetherapy
@ChildrensPhila
@PennMedicine
@PennCancer
@EWhiteheadFdn
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🚨NEW: CAR T cells produced in vivo to treat cardiac injury
#CARTCell
#TCell
#Tcellrx
#genetherapy
@PennMedicine
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The Age of Cell Therapy is here. Emily Whitehead shows you why. 🙏
Emily Whitehead became the first child to receive genetically-modified T cell to treat her leukemia. Her story helped launch
@EWhiteheadFdn
and the field of cellular medicine, as told in a new book,
#TheSongoftheCell
by the Pulitzer Prize-winning,
@DrSidMukherjee
.
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#OTD
celebrating 10 years since 1st CAR19
#Tcell
infusion
@PennMedicine
We thank all patient
#Heroes
for volunteering to advance
#cancer
#Immunotherapy
🙏🦸♂️🦸♀️
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🚨New: Decade-long
#leukemia
remissions with persistence of CD4+ CAR T-cells demonstrates long-term potential and clonal stability of
#CARTCell
therapy
#tcell
#tcellrx
#cancer
#immunotherapy
@PennMedicine
@Nature
Portfolio
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🙏Words are not adequate to describe the feeling standing next to
#CARTCell
hero Emily Whitehead 9 years after. Thanks to
@EWhiteheadFdn
for supporting
#immunotherapy
#cancerresearch
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#CARTCell
Team with CAR T Cellebrity Emily Whitehead w parents Tom and Kari
@EWhiteheadFdn
@PennMedicine
@PennCancer
@CHOPCancerCntr
@ChildrensPhila
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🚨🚨Carl June to receive 2024 Breakthrough Prize in Life Sciences
#immunotherapy
#tcell
#CARTcell
#tcellrx
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Today we celebrate
@EWhiteheadFdn
12 years cancer free 👏, and give our thanks to all patients who have contributed to
#CARTCell
#immunotherapy
development.
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It is with a heavy heart that we received the very sad news of the passing of our 1st CART19
#Tcell
patient. Bill Ludwig was a true
#cancer
#immunotherapy
pioneer and a humble
#hero
1/x
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A Happy Happy Birthday to Emily Whitehead!!! No longer a poster "child", but having paved a new path for the first
#FDA
approved
#genetherapy
is now continuing to write a better story for kids with
#Cancer
@EWhiteheadFdn
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🚨NEW Commentary on
#FDA
11/28/23 announcement "Unanswered questions following reports of secondary malignancies after CAR-T cell therapy"
@NatureMedicine
- A consensus commentary from
@ISCTGlobal
@ASTCT
@TheEBMT
@CIBMTR
@parkerici
@mpasca
@John_E_Connolly
David Porter
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Compassion creating joy, a lesson in how to be more human
@Goodable
Dont we all need more good news lately?
A judge at a dog show saw a young girl watching from the sidelines.
The girl had autism, and she'd brought her stuffed animal.
So the judge stopped, walked over to her, and asked if she wanted to show her dog, just like the others.
This is what happened.
❤
(
@akcdoglovers
)
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CAR T Cell dose - in the short term (1-3 mo) cell dose does not matter, but in the long term, it does matter.
Higher doses of
#tisagenlecleucel
associate with improved outcomes.
#tcellrx
#immunotherapy
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Many questions unanswered from the FDA report:
Colleagues I've consulted with are very surprised by this as we haven't seen. Questions:
-what was the clinical status of the patients in terms of immunosuppression, prior therapy, conditioning chemotherapy,
FDA investigating whether CAR-T, a treatment for cancer, can also cause lymphoma via
@statnews
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An encore annual picture🙏
Emily Whitehead 11 years on & celebrating a cure! This is why we do what we do
#CARTCell
#tcellrx
#immunotherapy
#celltherapy
#genetherapy
#writeabetterstory
@ChildrensPhila
@PennMedicine
@PennCancer
@EWhiteheadFdn
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Selfie with
@ladygaga
after talking about T cells
Tell me a story about yourself the sounds like a lie but is absolutely true.
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🚨CARTCell hero Emily Whitehead 9 years
#cancerfree
pic has dropped!
@EWhiteheadFdn
#celltherapy
#GeneTherapy
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Woman on left and right are the same person. SLE before and after CD19 CAR-T treatment. 🤯
Due to wax and wane in SLE, it has been hard to prove drugs work. Much easier when you cure patients! No relapses for 8 patients 4-29 months followup.
#ash23
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Let this sink in: “97% response rate, a deep response rate of 80% — we don’t even see that in first line [for
#myeloma
] so to see that even in a relapse refractory population - that’s such a huge thing,”
#FDA
#CARTCell
#immunotherapy
via
@statnews
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More good news like this please
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#TBT
when the pioneer/trailblazer/hero/inspiration met her CAR T cells
#immunotherapy
#tcell
#tcellrx
#CARTCell
10 years ago today we were at
@CHOPCancerCntr
preparing for Dr. Grupp to administer the first of three
#CARTcell
infusions to Emily.
In that moment there were still many unknowns, but we did know that if it worked it would make medical history.
#ActivateTheCURE
#10YearsofCART
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🚨Excited to announce the launch of Capstan Therapeutics - to Deliver on the Clinical Promise of Precise In Vivo Cell Engineering
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NEW Magnum Opus to date for CAR T cells in solid tumors - Product fitness, local delivery & pre-existing T cells in tumor impact responses. Congrats to Christine Brown
@cityofhope
team
@NatureMedicine
#immunotherapy
#CARTCell
#tcellrx
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Cancer research makes the impossible possible:
Emily Whitehead was the first child cured of cancer with therapy from Penn. She’s back as a freshman.
@Penn
@PennMedicine
@ChildrensPhila
#immunotherapy
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Cases of
#measles
have spread to vulnerable individuals, including hospitalized young children, due to people declining
#vaccination
and also failing to adhere to quarantine recommendations
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Antibody levels are easy to measure, T cell responses are not. Which is why Ab titers get the vast amount of attention, which does not equal relative importance.
12. Immunity isn't binary, says Thornburg, especially when you're talking about a respiratory infection.
What she's describing is more like a light dimmer than an on-off switch.
#ACIP
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10 years ago today I had the honor of meeting Emily Whitehead and her parents. Now we know what happens when an experiment exceeds your wildest
#immunotherapy
dreams
@EWhiteheadFdn
@ChildrensPhila
@PennCancer
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🚨NEW: PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial from
@PennMedicine
in
@NatureMedicine
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New generation of cancer-preventing vaccines enter early clinical trials for healthy people at high risk for disease
#cancer
#Immunotherapy
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I am incredibly honored and humbled to receive the Dennis Confer Innovate award. Thank you
@BeTheMatch
#ONEForum
Thank you to many many colleagues, and special thanks to our patients! 🙏♥️
Congratulations to Dr. Bruce Levine (
@BLLPHD
) for receiving the Dennis Confer Innovate Award at The
#ONEForum
. Thank you for your dedication and life-saving CAR-T research!
#BeTheMatch
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May I present, the
#Tcell
: 80% of epitopes in the spike protein recognized by CD8+ T cells are not affected by the mutations in the Omicron variant, two doses may still induce protection against severe disease
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Building better CAR-T therapies. Short take: it's hard, but we can and must do it for patients. Hey
@Rezvanilab
, that's you! cc
@GruppSteve
#Tcell
#celltherapy
#cancer
#Immunotherapy
@nature
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Today marks 30 years since I started my post-doctoral fellowship with
@carlhjune
@NavalMedicalRC
What a ride to
@PennMedicine
@PennCancer
#celltherapy
#GeneTherapy
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Dr. Fauci doesn’t sugarcoat his words and refuses to be pressured by politicians. He delivers the truth, as difficult as it may be to hear, earnestly and with one goal: to save lives. Amen!
#FauciHero
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Today is the 9th anniversary of 1st CART19 pt infusion
@PennMedicine
@PennCancer
He is healthy and doing great!
#celltherapy
#TCell
#leukemiafree
Reported here
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11 years since Emily Whitehead became the first child in the world to receive an experimental CAR T-cell therapy,
@EWhiteheadFdn
continues the fight against childhood cancers. Learn how CAR T-cell therapy is giving patients hope for the future:
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We like stair views. Art. Peek of dining room. For Christ’s sakes just get vaccinated. 10/10
@DrPaulOffit
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So, we talked T cells,
#Cancer
#cancerresearch
and
#immunotherapy
in January 2016. Tonight, opening for the Joe show
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The Emily Whitehead 8 years
#CancerFree
pic is in the house!
@PennMedicine
held here by dad Tom
@EWhiteheadFdn
@PedCancerCare
#celltherapy
#GeneTherapy
#Tcell
#Tcellrx
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Oh, the places you can go with synthetic biology - An engine upgrade for CAR
#TCell
#immunotherapy
"Potentiating adoptive cell therapy using synthetic IL-9 receptors"
@Nature
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A milestone anniversary in new
#cancer
therapies, we are celebrating with Emily, her family and all patient heroes today!
#celltherapy
#genetherapy
#tcell
#immunotherapy
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New
@NEJM
Base-edited CAR7 T cells show promise in treating relapsed T-cell ALL) In 3 pts, BE-CAR7 cells led to molecular remission, w 2 pts achieving ongoing remission after allo SCT. Long-term safety of BE-CAR7 tx TBD
#ALL
#CART
#celltherapy
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Today marks 25 years since my faculty appointment
@PennMedicine
, a surreal experience then as
@Penn
alum. None of us knew what the future would hold. Sometimes crazy
#immunotherapy
dreams come true.
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Carl H. June
@PennMedicine
Is Recipient of Inaugural Maria I. New International Prize for Biomedical Research
@MountSinaiNYC
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The world leader in
#genetherapy
product development is the University of Pennsylvania
@Penn
@PennMedicine
#science
#medicine
#innovation
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Here come the engineered B cells:
Immusoft Administers the First Engineered B Cell in a Human Clinical Trial
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🚨New: Rapid manufacturing of non-activated potent
#CARTcell
#immunotherapy
Let's call them Race CARs
#tcellrx
#tcell
@PennMedicine
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🚨
@Tribeca
Film Festival to Debut Documentary Tracing the Path to
@PennMedicine
&
@ChildrensPhila
Transformative, Personalized
#Cancer
Therapy
#celltherapy
#genetherapy
#CARTCell
#immunotherapy
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What's better than hanging out w
@NobelPrize
winner
@kkariko
? Having her autograph your copy.of her book Breaking Through: My Life in Science
@PennMedicine
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#Tcell
#Hero
Emily Whitehead running a 5K today to benefit kids with
#cancer
and
#immunotherapy
#cancerresearch
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Celebrating
@PennMedicine
Breakthrough Prize winners Virginia Lee (2020), Kati Kariko and Drew Weissman (2022), Carl June (2024)
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Why you can't make bazillion CAR
#TCell
doses from one allo donor: manufacturing techniques intended to increase cell number also increase time in culture, and increased ex vivo culture time can lead to exhaustion and decreased potency of the cells.
Will allogeneic CAR T cells for CD19+ malignancies take autologous CAR T cells ‘off the shelf’? - Amanda DiNofia &
@GruppSteve
discuss this issue in a new article now live online:
@CHOPCancerCntr
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Gene therapy success
Of 30 patients with severe
#SickleCellDisease
who were treated with gene-edited autologous hematopoietic stem and progenitor cells, 29 were free from vaso-occlusive crises for at least 12 consecutive months. Read the full CLIMB SCD-121 study results:
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Tony knows T cells
A Congressman asked Tony Fauci a question about T cells, and Fauci reached down and picked up our paper and waved it! COVID testimony today. I should make business cards with that screenshot. 😂doi:10.1016/j.cell.2020.05.015
@CellCellPress
@SetteLab
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10K
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The global CAR
#Tcell
therapy patent landscape - from
@NatureBiotech
h/t
@PennMedicine
@PennPCI
& colleagues
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Efficiencies gained by 3 day CAR
#tcell
manufacturing over 9 day process presented by Juliana Rojas-Levine. BTW, 3 day CAR T also more potent in clinical trial NCT04684563
@PennMedicine
#ISCT2023
#immunotherapy
@ISCTglobal
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If Kite has treated ~13,000 pts worldwide, that leads me to estimate ~25,000-30,000 pts worldwide have now received CAR T cell
#immunotherapy
. Yet, Christi Shaw has estimated that only ~20% of pts eligible have received. As a field, we must do better
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Thank you Dr. Fauci 👏👏👏
Anthony Fauci: A Message to the Next Generation of Scientists
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NEW:
#FDA
Approves First Gene Therapy for Children with Metachromatic Leukodystrophy. Lenmeldy (atidarsagene autotemcel) is gene modified hematopoietic stem cells with a functional copy of arylsulfatase A
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🚨Huge win for patients, and for science - Authorization of the First CRISPR/Cas9 Gene-Edited Therapy, CASGEVY™ (exagamglogene autotemcel), by the United Kingdom MHRA for the Treatment of Sickle Cell Disease and Transfusion-Dependent Beta Thalassemia
@VertexPharma
@CRISPRTX
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@Number10cat
has better judgement than some humans
What’s happening isn’t your fault. You’ve made sacrifices, while given advice that’s been inconsistent at best and contradictory at worst. People in power have set a bad example. I’m sorry you’re being asked to do more and disgusted you’re being blamed.
#covidbriefing
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A day late, but wishing everyone Happy CD3/CD28 T Cell activation Day 😉
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🚨NEW Magnum Opus - A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer
@NatureCancer
led by
@CoukosGeorge
@Ludwig_Cancer
Janos Tanyi
@carlhjune
@PennMedicine
et al.
#OvarianCancer
#Immunotherapy
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Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results in
@NatureMedicine
Results are significant to further demonstrate Claudin18.2 as
#cancer
target. 6mo DOR of 44.8% one wishes would be better
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It is a true honor to be receiving the Jerry Mendell Award for Translational Science from
@ASGCTherapy
. I must recognize the amazing teams
@PennMedicine
,
@PennCancer
, the Center for Cellular Immunotherapies, and the Clinical Cell and Vaccine Production Facility. We know that
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#CARTCell
#immunotherapy
pioneer makes a statement on durability of
#tcellrx
@PennMedicine
@PennCancer
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Nice review: CAR-T cell manufacturing: Major process parameters and next-generation strategies. By Yvonne Chen et al.
@JExpMed
#OpenAccess
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NEW from
@RahulBanerjeeMD
David Maloney & colleagues: Answering the "Doctor, can CAR-T therapy cause cancer?" question in clinic
@BloodAdvances
Immortal time bias = if pts don't live longer (thanks to CAR T), secondary malignancy won't be observed
#cancer
#immunotherapy
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Phase I Trial of huCART19-IL18 Cells in Patients With R/R CD19+ NHL or CLL, pts who must be relapsed/refractory to prior CAR T cell therapy if indicated by FDA label. 82% ORR
Armoured CAR-T - huCART19-IL18.
• Secretion of IL18 may have autocrine / microenv / direct cytotox action
• Small no patients but all prior CAR-T
• mix B-cell NHL
• High ORR, some durable
• No unexpected safety.
Impressive responses after CAR-T failure. # 17ICML
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$190 Million "Next Generation" Cell And Gene Therapy Research Production Center In University City
#Philly
#CelliconValley
#celltherapy
#genetherapy
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👏CAR
#TCell
#immunotherapy
applications are expanding, significant report
@NatureMedicine
Anti-CD19 CAR T cell therapy for refractory systemic
#lupus
erythematosus
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Found! At
#ASH19
exhibit of history CAR
#Tcell
therapy, a 1997 pic of me with colleagues Carl June, Jim Riley et al
#CellTherapy
#genetherapy
#immunotherapy
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#FDA
approves Novartis
#Kymriah
CAR-T cell
#immunotherapy
for adult patients with relapsed or refractory follicular
#lymphoma
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Today is the day! Grateful and thrilled for patients. FDA approval brings first gene therapy to the United States
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If CAR T Cells & mRNA LNP vaccines had a baby, that would give the transformative technology of targeted LNPs encoding CARs
@capstantx
@lshawverO
Bright Minds: Capstan Therapeutics' CEO
@lshawverO
on 'decorating' LNPs with antibodies.
#SITC23
Full video:
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I am truly honored to have been elected to
@ACGTFoundation
Board of Directors. ACGT was founded by philanthropic visionaries Barbara and Edward Netter. An ACGT grant awarded to
@carlhjune
in 2004 first funded our pre-clinical CAR T studies. I look forward to supporting the
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This year, CAR T cell
#immunotherapy
at the Breakthrough Prize Ceremony, also known as “the Oscars of Science,” an awards show unlike any other.
Carl June and Michel Sadelain are the Qs who supplied a secret agent – the CAR T cell – with the technology to liquidate cancers. They will be honored at the Breakthrough Prize ceremony. Watch the worldwide premiere April 21 — streaming here and at .
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This feels like 10,000 patients will be treated with commercial CAR T Cell
#Immunotherapy
during 2023
Total
#CART
sales 793m$ in Q4, total 2.7b$ in 2022 vs 1.7b$ in 2021 (+59%) $BMY $GILD $NVS $JNJ $LEGN
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👏👏 Sequential administration of FAP-
#CARTcell
#immunotherapy
then Meso-CAR T enhances systemic endogenous adaptive anti-tumor immunity in pancreatic
#cancer
models. Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid
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