Yaser Hashem
@Hashemyaser4
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Group leader (Ph.D.) at the Inserm, in the fields of molecular and structural biology.
Bordeaux, France
Joined January 2019
It's a great pleasure to share our latest collaborative work detailing the composition and structure of the highly rRNA-fragmented mitoribosome from Apicomplexa, such as Plasmodium falciparum and Toxoplasma gondii, now out in @NatureComms
https://t.co/Ly7JeipU8W
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We are hiring…position suitable for PhD student with interest in ribosomes, antibiotics and cryoEM… https://t.co/8SN6Yn2CJw
uni-hamburg.de
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BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has
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Delighted to announce our latest work on how Wadjet loads onto and establishes topological entrapment of plasmid DNA prior to initiating loop extrusion. At Stephan Gruber's lab in Lausanne, @DCI_EM and BSI @IGBMC and with @drhonsworth
https://t.co/LiDOmr0xPo
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GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science
science.org
During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular...
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It was a great honor to give two lectures at @UniversityOFBel School of Medicone today as an invited lecturer (visiting professor). Hope to do this soon again and continue with scientific collaboration.
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Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal : https://t.co/YmsR18WcRJ
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Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @NatureSMB🥳 https://t.co/5SaPnwQ4zf Massive team effort led by @leonie_anton @mehsehret @Wenjing_Cheng_ in collaboration with @DziekanJerzy @CowmanAlan #teamtomo
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In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes:
nature.com
Nature Chemical Biology - Mo, Chen, Cui and colleagues report a proximity-labeling-based method termed TAPRIP for profiling RNA–protein interactions in living cells, enabling the...
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Excited to share our new @NatureMicrobiol paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩@TheColinMann @HarvardMicro @VirologyHarvard
nature.com
Nature Microbiology - Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that...
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New online! Structural insights into higher-order natural RNA-only multimers https://t.co/KOjh7CNWSd
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Finally out 🤓 great collaboration with @slavicaPD and @DjuranovicLab
Our RAPPL purification of ribosomes and associated material is finally out. I am really proud of this study in collaboration primary with @slavicaPD lab, as well as Marko Jovanovic and @Hashemyaser4 Labs. This method aims to replace 60 years old purification of ribosomes by
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A paper in @NatureNeuro suggests that the brain detects when a potential source of infection enters the immediate surroundings and prepares the body’s immune defenses. This may occur even before physical contact is made, in a virtual reality environment. https://t.co/qGw109Sr7m
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Pre-print out from the @SternbergLab with our contribution on the structural side. Great effort from Matt, Egill Tanner and the rest of the team leaded by awesome Sam! A 1 year effort on my side learning helical reconstruction by cryoEM... 👇
1/16 New pre-print from the Sternberg Lab! We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: https://t.co/rh4PoOWn9l
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1/16 New pre-print from the Sternberg Lab! We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: https://t.co/rh4PoOWn9l
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New online! A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients https://t.co/I1MLkRFJUu
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ROOL monomers entangle with other monomers via strand swapping to form octameric nanocages. https://t.co/kThZa5hsMS
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New story - the structure of the Vault cap at 2.3 Å! Fantastic work by Huan Li (@huanli00). For more details, read the preprint, or check out my thread at the other place! 😊🟦☁️ https://t.co/8rWD6FRP5q
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🎉 Congrats to ERC grantee Wolfgang Baumeister @MPI_Biochem, awarded the 2025 #ShawPrize in Life Science & Medicine for pioneering work in cryo-ET! Learn more 👉 https://t.co/dI2vt6vIqs
#ERCSYG #CryoET #StructuralBiology #shawprize2025
@TU_Muenchen @ShawPrize @maxplanckpress
erc.europa.eu
2025 Shaw Prize honours ERC-funded research in molecular imaging
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In our newly published study we show that the proline-rich antimicrobial peptide (PrAMP) Bac5 has a distinct mode of interaction with the ribosome compared to other PrAMPs… https://t.co/AECODPspzg
academic.oup.com
Abstract. Proline-rich antimicrobial peptides (PrAMPs) are produced as part of the innate immune response of animals, insects, and plants. The well-charact
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