Ahmad Jomaa
@jomaa_lab
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Assistant Professor at the University of Virginia, Biochemist, Molecular and Structural Biologist, Husband, Father, Traveller #cryoem #ribosome #rna
Charlottesville
Joined August 2016
Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal : https://t.co/YmsR18WcRJ
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Learn how our hunt for the native structure of top #antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms 👉 https://t.co/SX5vBW1ZzT 🦠🔬❄️ A team effort by @mehsehret @cmholab & Anurag Shukla @AkhilVaidya1 #cryoEM
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Our DeFrND approach is finally published. A simple trick to isolate membrane proteins with native lipids for structural and functional characterization.
nature.com
Nature Communications - To bypass the limitations of detergents, Ren et al. developed peptide scaffolds that extract membrane proteins directly into lipid nanodiscs, preserving the native...
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Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: https://t.co/4WJcgdgRY7
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Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin @shuramankin identifying the first translation inhibitor binding to the E-site of the bacterial ribosome…
researchsquare.com
A significant challenge in addressing the antibiotic resistance crisis is identifying new antimicrobial compounds. Although natural products produced by fungi and bacteria, particularly actinomycet...
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Sharing some of my PhD work that just came out today. TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5) https://t.co/ntiukQdEcw
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Check out our latest preprint with Qi lab on the structure and disease physiology of the human ERAD complex. Outstanding work by Leo, a cell physiologist whom we successfully tempted into structural biology! Preprint: https://t.co/ebaTAJdFNN
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Check out our new paper on the entire E. coli type 1 pilus structure. Many thanks to all coauthors!
nature.com
Nature Communications - Adhesive, filamentous type 1 pili are critical virulence factors in urinary tract infections. Here, the authors describe the cryo-EM structures of the entire type 1 pilus...
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In our newly published study we show that the proline-rich antimicrobial peptide (PrAMP) Bac5 has a distinct mode of interaction with the ribosome compared to other PrAMPs… https://t.co/AECODPspzg
academic.oup.com
Abstract. Proline-rich antimicrobial peptides (PrAMPs) are produced as part of the innate immune response of animals, insects, and plants. The well-charact
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Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ @jpkreysing, Johannes Betz,Turoňová lab, @MarinaLusic, Hummer lab, @Beck_Laboratory, @MPIbp 🔗 Preprint here: https://t.co/0tTxZcu0Vz
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Fresh off the press…our latest study on the Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | great collaboration with @inada_lab and Zaher lab. Data collected at @DCI_EM. PNAS
pnas.org
The integrated stress response (ISR) is a central signaling network that enables eukaryotic cells to respond to a variety of different environmenta...
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Excited to share our new preprint on co-transcriptional splicing! U1 snRNP is recruited to RNA polymerase II through multiple interaction sites, with elongation factor SPT6 binding directly to the U1 snRNP protein. https://t.co/6CItEE2X4d
#cryoEM #transcription #splicing
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1/2 Here we unexpectedly find that protein S20/L26—identified at the dawn of ribosome research but then deemed a ribosome isolation artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation:
nature.com
Nature Communications - Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that...
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The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @ScienceMagazine 🎉 You can find the full story here https://t.co/5DaDHXjE6z
@luminous_lab did a wonderful job on the cover and animation👩🎨
science.org
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain,...
In mitochondria, respiratory supercomplexes (blue) pump protons across crista membranes to create an electrochemical gradient, fueling adenosine triphosphate (ATP) synthase (pink) to regenerate ATP—the energy currency of life. Now, cryo–electron tomography captures these
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Our paper “Blocking IF3N delays bacterial translation initiation” is out on #biorxiv Awesome work from @ana_sancas and @Ka_li44 in collaboration with friends from @WilsonLab2 and @akonevega labs! https://t.co/IE1OD4fIvi
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People who are more extrinsically motivated – those interested in fame, power, and money – are more likely to do unethical things to advance their careers, new research shows.
news.stanford.edu
Ambition is a predictor of success. But according to a new study, the motives behind it can also lead to lying and cheating.
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Ever wondered how Pol II speed is controlled during productive elongation? Our study reveals that the helicase RECQL5 triggers transcription braking, while the transcription-coupled DNA repair complex restores the elongation rate. #cryoEM #transcription
https://t.co/ViwoGIz74o
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🆕 #preprint by Karagoz lab & us on the crosstalk between #UFMylation & #RQC (ribosome-associated quality control) https://t.co/8RgM7yPxLJ As always let us know what you think!
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