All life depends on accurate translation (both intracellular & international). Using time-resolved cryo-EM, we watched ribosomes decode mRNA, aided by EF-Tu and GTP. See our animations & article ( on how ribosomes proofread tRNAs to make correct proteins:

ROOL monomers entangle with other monomers via strand swapping to form octameric nanocages.

With our RTI colleagues Xiaobin Ling and @WenwenFang2, we report cryo-EM structures of enigmatic bacterial RNA nanocages made of long-noncoding ROOL RNAs. Octamers are held by "A-minor staples" and other interactions. Congrats Xiaobin, Dima et al!.

Activation of Retron-Septu for antiphage defense. Congrats @futianmin and all co-authors!.

RT @rubenlgonzalez: “Undermining the future of American science is not a path to accountability — it’s a path to decline.”.In a powerful ne….

RT @WilsonLab2: In our newly published study we show that the proline-rich antimicrobial peptide (PrAMP) Bac5 has a distinct mode of intera….

RT @cureffi: We developed a new siRNA drug candidate for prion disease, a @broadinstitute / @RTI_UMassChan collaboration. We now have an op….

RT @MariuszCzC: I’m happy to share our recent manuscript in which we are structurally and biochemically investigating 3'-5' tRNA splicing l….

RT @WilsonLab2: Fresh off the press…our latest study on the Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | gre….

RT @UMassChan: Anastasia Khvorova, PhD, named 2025 Else Kröner Fresenius Prize for Medical Research awardee for her pioneering work in the….

RT @slavov_n: Biological systems find ingenuous solutions. Almost anything that can happen, happens. Still, I would not have guessed a rol….

RT @MarvinTanenbaum: Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation b….

RT @KarinaJouravl: Our review on small endogenous RNAs in animals is online. We thank @MartinjSimard, @SvobodaLab and the third, anonymous,….

Gabriel Demo and colleagues report how a small archaeal protein (aRDF) dimerizes 30S subunits to prevent ribosome formation:.

RT @DmitriErmolenko: Using reporters with long unstructured 5’ UTRs, we examined which initiation factors are limiting for 40S scanning. Ou….

RT @Hashemyaser4: It's a great pleasure to share our latest collaborative work detailing the composition and structure of the highly rRNA-f….

RT @rubenlgonzalez: Our latest work is out in @Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5….

Congratulations Matt and all co-authors. It's exciting that you harnessed RNase L for a specific RNA cleavage!.

RiSANA is online!. We report the Ribosome Stimulated Angiogenin Nuclease Assay (RiSANA) and explore: (a) if Angiogenin is activated by bacterial 70S ribosomes; and (b) if closest homolog RNase 4 is stimulated by 80S: Congrats Emily Sholi and Anna Loveland!

RT @AlbertW_Lab: We are excited to share our latest work on the cooperation between RNA polymerase and the ribosome in bacteria: https://t.….

"A-minor-like motifs are the most populated contacts in RNA structures":.