Chi-Min Ho
@mimi1inh
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#NewPI of the @cmholab @Columbia_MI. Using CryoEM/ET to study malarial membrane protein complexes. Co-host of #ThePlungePodcast @ https://t.co/5crCxDkeUN.
Joined May 2017
Magnesium site in human oncochannel TRPV6 is formed by two negatively charged residues that are close together in the closed state and separated in the open state. Magnesium binding keeps these residues together and stabilizes the closed state. https://t.co/axq2Vczugl
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Exciting news!! I’ve been awarded an #SNSFStartingGrant and will join the Institute of Parasitology, @UZH_en as an Assistant Professor in summer 2026. A dream come true! 🥺
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Beautiful work using #insitu #cryoEM #SingleParticleAnalysis from @guowangbiao @YaleMicroPath in @NatureMicrobiol
https://t.co/UZIjxpOL72
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Thrilled that our study on heme crystal motion in #malaria @parasitesrule is now published @PNASNews, @UofUBiochem @UofUtahCIHD @UofUHealth. Fantastic collaboration! https://t.co/KEKKxwewUa
pnas.org
Malaria parasites infect red blood cells where they digest host hemoglobin and release free heme inside a lysosome-like organelle called the food v...
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Learn how our hunt for the native structure of top #antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms 👉 https://t.co/SX5vBW1ZzT 🦠🔬❄️ A team effort by @mehsehret @cmholab & Anurag Shukla @AkhilVaidya1 #cryoEM
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Excited to share that our paper on mitochondrial cardiolipin dynamics is published in @NatureComms today! We provide molecular explanations for unique aspects of mitochondrial morphology and the mechanisms underlying cardiolipin-related Barth Syndrome. https://t.co/xNckXoMKF3
nature.com
Nature Communications - This study reveals how cardiolipin governs mitochondrial morphology by modulating the activity of human OPA1 and how its replacement by monolyso-cardiolipin, as observed in...
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Congratulations, Yifan, for the Anatrace Award! Yifan’s work on the TRPV1 structure with David Julius helped launch the Resolution Revolution in cryo-EM. Not just in membrane proteins—hardly any area of biophysics today has remained untouched by the techniques Yifan pioneered.
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How does hunger spur us to consume? @Columbia scientists have found a brain area that drives mice to consume sweets, fats, salt & food. This finding may inform novel treatments for both overeating and undereating. See @CellCellPress #neuroscience
https://t.co/PRVLrcIejg
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The Lander Lab is now hiring a postdoc to investigate cAMP signaling pathways in T. cruzi. Prospective candidates should be enthusiastic, proactive, and passioned about science! Use this link to apply: https://t.co/jqa6zTsHZL
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This 1998 paper is, without question, one of the most beautiful in the history of biology. It answers two questions: First, how does a potassium channel let in K+ ions while excluding Na+ ions? And second, how does it funnel 100 million of those ions through each second? These
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Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal : https://t.co/YmsR18WcRJ
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Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex | Science
science.org
Malaria parasite fertilization occurs in the midgut of a female Anopheles mosquito. Blocking fertilization within the mosquito can prevent malaria transmission. Plasmodium falciparum Pfs230 and...
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Happy to share structures of kainate receptor channel GluK2 in complex with auxiliary subunits Neto2, which slow receptor kinetics, in apo closed and open conducting states, both with 2-fold symmetrical LBD layer! @shantigangwar @MariaKarela3 @LauraYen42
https://t.co/r4RWqXAxCn
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New online! Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug https://t.co/PCq38IjXjm
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Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @NatureSMB🥳 https://t.co/5SaPnwQ4zf Massive team effort led by @leonie_anton @mehsehret @Wenjing_Cheng_ in collaboration with @DziekanJerzy @CowmanAlan #teamtomo
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Out Now! HIV-1 nuclear import is selective and depends on both capsid elasticity and nuclear pore adaptability https://t.co/536wnBx4Hp
#HIVResearch #ViralScience #Microbiology
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In our latest preprint on bioRxiv, we present the in situ structure of the human gap junction at 14 Å resolution using cryo-ET. The structure provides a blueprint for investigating how connexin regulation shapes intercellular communication in health and disease.
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We have a preprint for you EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer By Elena Vazquez-Sarandeses, Vasya @v_mikirtumov Jeff Noel&Oli Daumke https://t.co/kq450wTJkV
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Check out our latest preprint with Qi lab on the structure and disease physiology of the human ERAD complex. Outstanding work by Leo, a cell physiologist whom we successfully tempted into structural biology! Preprint: https://t.co/ebaTAJdFNN
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Exciting findings from @JunLiuLab #postdoc @YueJianUSTC @YaleMed Architecture and activation of the Legionella Dot/Icm type IVB secretion machine #cryoEM #cryoET #Legionella
biorxiv.org
The Dot/Icm machine in Legionella pneumophila is one of the most versatile type IV secretion systems (T4SSs), with a remarkable capacity to translocate over 330 different effector proteins across the...
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