1/16 New pre-print from the Sternberg Lab!.We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here:

Ribosome density is often used as a surrogate for translation efficiency. However, this article suggests differences in translation elongation rates across mRNAs:. ⬛️ Translation elongation rates vary up to ∼ 20-fold among transcripts. 🧵

🚨 Extremely excited to share that I’m joining @Columbia University as an Assistant Professor!. The Thawani Lab will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. We’re hiring at all levels! If

Today in 1945, George Orwell published a devastating critique of Communism. Animal Farm reveals why every communist revolution follows the same tragic pattern: liberation to corruption to oppression. Here are 10 truths from Animal Farm Orwell warned us never to forget 🧵👇🏼

ProteinGenerator simultaneously generates protein sequences and structures using sequence space diffusion

An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting 🦠 m1G (TrmD) at position 37 modulates tRNA conformation on ribosome and suppresses +1 FS induced by tRNA-Pro (four base pair codon-anticodon) 💫.

‘Protein evolution as a complex system’ – A new Comment discusses protein evolution in terms of complex systems theory and machine learning approaches to model the dynamics of protein evolution.

New online! Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Now published in @NatureComms! 🥳. 👉 We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces and combined soft matter physics with experimental biology. 1/n

My paper is out in @ScienceMagazine!. We found a novel host defense strategy where #mitochondria, our domesticated microbes, compete with the intracellular pathogen #Toxoplasma for #folate.

The high-throughput magnetic IgG purifier is complete. Our tech transfer encouraged me to patent it, but I follow Jonas Salk's example and make a gift to humankind. You can make it with this plan or I will make you one at zero-profit cost

#Guanidine was known since the 1870s to affect muscle function. Vertebrates have guanidine-sensing #riboswitch RNAs linked to genes relevant to muscle disorders, including some for Ca2+ signaling and others relevant to #ataxia symptoms. @NatureComms

A new paper, published in PNAS, suggests that "large groups of editors and authors. cooperated to facilitate publishing fraud." The authors used statistical analyses and huge databases of papers to figure this out. But first, some context on paper mills. There is a well-known

MOSAIC 4D movie of zebrafish cellular dynamics and internal responses to a tail cut injury, as seen in the adaptive optical lattice light sheet mode, over 12.5 hrs at 3 min intervals.

First cryo-EM map of Apoferritin from our new @JEOL_Japan @JEOLUSA @JEOLEUROPE cryoARM300-II with @DirectElectron Apollo detector. Collected over night and processed in 1 day with @cryosparc using all-default settings from only 76k particles. H/R B-factor=28 at 1.5A. Not too

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors

New online! Structural insights into higher-order natural RNA-only multimers