@AbrahamLabHMS
@abrahamlabhms
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Visualizing how viruses infect cells using tools in structural biology.
Joined May 2020
Out Now! Molecular organization of the New World arenavirus spike glycoprotein complex https://t.co/fisCxzUVOE
#Arenavirus #MolecularBiology #CryoEM
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Though the Candid#1 vaccine is effective against JUNV, other lethal New World areaviruses still pose a large public health risk 🌎with no specific medical countermeasures. Our structures may serve as a basis for further rational design and development of therapeutics and vaccines
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A K33A substitution in the stable signal peptide (SSP) allowed for stabilization of the pre-fusion GPC, with molecular dynamics suggesting K33A stabilizes GPC by better accommodating membrane lipids in the SSP33 pocket, supported by our cryo-EM density
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Further structural and functional analyses also reveal the effect of specific residues in transmembrane and membrane proximal region on pH-mediated fusion, elucidating the attenuation mechanism of the JUNV Candid#1 vaccine 💉
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These cryo-EM structures reveal notable differences between JUNV and MACV in GP1 organization at the apex and C terminus. The MACV GPC apex has a more open appearance due to its GP1 subunits slightly rotating outwards and clockwise 🔃compared to JUNV GP1 subunits
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Our recent @NatureMicrobiol paper provides the most complete insight into the molecular organization of the JUNV and MACV GPCs yet 😲revealing new features not seen in previous structures, such as the TM helices and cytosolic portions, including ZBD
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New World arenaviruses, like Junin virus (JUNV) and Machupo virus (MACV), cause hemorrhagic fever with fatality rates as high as 30% predominantly in South America. To date, the only medical countermeasure against these viruses is the Candid#1 vaccine effective only against JUNV
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Excited to share our new @NatureMicrobiol paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩@TheColinMann @HarvardMicro @VirologyHarvard
nature.com
Nature Microbiology - Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that...
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Though the Candid#1 vaccine is effective against JUNV, other lethal New World areaviruses still pose a large public health risk 🌎with no specific medical countermeasures. Our structures may serve as a basis for further rational design and development of therapeutics and vaccines
0
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A K33A substitution in the stable signal peptide (SSP) allowed for stabilization of the pre-fusion GPC, with molecular dynamics suggesting K33A stabilizes GPC by better accommodating membrane lipids in the SSP33 pocket, supported by the cryo-EM density.
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Further structural and functional analyses also reveal the effect of specific residues in transmembrane and membrane proximal region on pH-mediated fusion, elucidating the attenuation mechanism of the JUNV Candid#1 vaccine 💉
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These cryo-EM structures reveal notable differences between JUNV and MACV in GP1 organization at the apex and C terminus. The MACV GPC apex has a more open appearance due to its GP1 subunits slightly rotating outwards and clockwise 🔃compared to JUNV GP1 subunits.
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Our recent @NatureMicrobiology paper provides the most complete insight into the molecular organization of the arenavirus GPCs yet 😲revealing new features not seen in previous structures, such as the TM helices and cytosolic portions, including ZBD.
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New World arenaviruses, like Junin virus (JUNV) and Machupo virus (MACV), cause hemorrhagic fever with fatality rates as high as 30% predominantly in South America. To date, the only medical countermeasure against these viruses is the Candid#1 vaccine effective only against JUNV
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If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫 We're excited to share our published work developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. https://t.co/k3PyY1ZPG8
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Out Now! Ecology and evolutionary trajectories of morbilliviruses in Neotropical bats https://t.co/BgKrwmT4qI
#Ecology #Evolution #Morbillivirus
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Excited to share a preview on "Decoding WEEV’s host adaptation" in @cellhostmicrobe featuring papers from @abrahamlabhms, @msdiamondlab and Daved Fremont lab. 😀😀 https://t.co/MnTMc3OSFO
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TWiV podcast discussing our recent @CellCellPress paper on shifts in receptor use by an encephalitic arbovirus! Congrats @wanyuviridae @xiaoyi_fann @HarvardMicro. Thank you @profvrr for covering! 🥳🐴🐦⬛🦟 https://t.co/t8Ec6jJK4a
microbe.tv
TWiV reviews pause in the use of Chikungunya vaccine, HHS to stop recommending COVID shots for pregnant women and children, molecular basis for shifted receptor recognition by encephalitic alphavir...
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New research featured in @Nature from Joel Tan of @DanaFarber’s Kranzusch Lab ( https://t.co/Q1OXPsSIES) reports the first example of an inhibitory nucleotide immune signal. Read more: https://t.co/Zoc1h4nnrZ
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