@AbrahamLabHMS
@abrahamlabhms
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Visualizing how viruses infect cells using tools in structural biology.
Joined May 2020
RT @NatureMicrobiol: Out Now! Molecular organization of the New World arenavirus spike glycoprotein complex #Arenav….
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Though the Candid#1 vaccine is effective against JUNV, other lethal New World areaviruses still pose a large public health risk 🌎with no specific medical countermeasures. Our structures may serve as a basis for further rational design and development of therapeutics and vaccines.
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A K33A substitution in the stable signal peptide (SSP) allowed for stabilization of the pre-fusion GPC, with molecular dynamics suggesting K33A stabilizes GPC by better accommodating membrane lipids in the SSP33 pocket, supported by our cryo-EM density
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Further structural and functional analyses also reveal the effect of specific residues in transmembrane and membrane proximal region on pH-mediated fusion, elucidating the attenuation mechanism of the JUNV Candid#1 vaccine 💉
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These cryo-EM structures reveal notable differences between JUNV and MACV in GP1 organization at the apex and C terminus. The MACV GPC apex has a more open appearance due to its GP1 subunits slightly rotating outwards and clockwise 🔃compared to JUNV GP1 subunits
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Our recent @NatureMicrobiol paper provides the most complete insight into the molecular organization of the JUNV and MACV GPCs yet 😲revealing new features not seen in previous structures, such as the TM helices and cytosolic portions, including ZBD
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New World arenaviruses, like Junin virus (JUNV) and Machupo virus (MACV), cause hemorrhagic fever with fatality rates as high as 30% predominantly in South America. To date, the only medical countermeasure against these viruses is the Candid#1 vaccine effective only against JUNV.
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Excited to share our new @NatureMicrobiol paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩@TheColinMann @HarvardMicro @VirologyHarvard
nature.com
Nature Microbiology - Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that...
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Though the Candid#1 vaccine is effective against JUNV, other lethal New World areaviruses still pose a large public health risk 🌎with no specific medical countermeasures. Our structures may serve as a basis for further rational design and development of therapeutics and vaccines.
0
0
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A K33A substitution in the stable signal peptide (SSP) allowed for stabilization of the pre-fusion GPC, with molecular dynamics suggesting K33A stabilizes GPC by better accommodating membrane lipids in the SSP33 pocket, supported by the cryo-EM density.
1
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Further structural and functional analyses also reveal the effect of specific residues in transmembrane and membrane proximal region on pH-mediated fusion, elucidating the attenuation mechanism of the JUNV Candid#1 vaccine 💉
1
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0
These cryo-EM structures reveal notable differences between JUNV and MACV in GP1 organization at the apex and C terminus. The MACV GPC apex has a more open appearance due to its GP1 subunits slightly rotating outwards and clockwise 🔃compared to JUNV GP1 subunits.
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Our recent @NatureMicrobiology paper provides the most complete insight into the molecular organization of the arenavirus GPCs yet 😲revealing new features not seen in previous structures, such as the TM helices and cytosolic portions, including ZBD.
1
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New World arenaviruses, like Junin virus (JUNV) and Machupo virus (MACV), cause hemorrhagic fever with fatality rates as high as 30% predominantly in South America. To date, the only medical countermeasure against these viruses is the Candid#1 vaccine effective only against JUNV.
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RT @TheColinMann: A great #ASV2025 with old friends, new friends, and awesome labmates from @abrahamlabhms!
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RT @WeingartenShira: If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫.We're excited to share our publi….
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RT @NatureMicrobiol: Out Now! Ecology and evolutionary trajectories of morbilliviruses in Neotropical bats #Ecology….
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Excited to share a preview on "Decoding WEEV’s host adaptation" in @cellhostmicrobe featuring papers from @abrahamlabhms, @msdiamondlab and Daved Fremont lab. 😀😀.
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TWiV podcast discussing our recent @CellCellPress paper on shifts in receptor use by an encephalitic arbovirus! Congrats @wanyuviridae @xiaoyi_fann @HarvardMicro. Thank you @profvrr for covering! 🥳🐴🐦⬛🦟.
microbe.tv
TWiV reviews pause in the use of Chikungunya vaccine, HHS to stop recommending COVID shots for pregnant women and children, molecular basis for shifted receptor recognition by encephalitic alphavir...
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RT @DanaFarberNews: New research featured in @Nature from Joel Tan of @DanaFarber’s Kranzusch Lab ( reports the fir….
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