Eddie Rashan
@EdreesRashan
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Lipid metabolism biochemist. Postdoc @mvh_lab @KochInstitute | he/him | BlueSky: @edreesrashan.bsky.social
Cambridge, USA
Joined September 2019
As promised, a 🧵 on our recent article now out in @NatureSMB! Co-led with @AbbyBartlett_ @Pagliarini_Lab @JudithSimcox, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯#lipidtime
nature.com
Nature Structural & Molecular Biology - Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and...
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November Molecule of the Month: GLP-1 Receptor Agonists Popular and effective drugs for the treatment of obesity and diabetes https://t.co/DLhf2nngLk
pdb101.rcsb.org
Popular and effective drugs for the treatment of obesity and diabetes
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Happy to have contributed to this awesome finding! We identify a mechanism by which acetoacetate drives anti-tumor immunity in the gut.
Check out the latest pre-print from the lab! Great work led by Slater Clay @SlaterC_ Oral acetoacetate reduces tumor burden in colon cancer models by forming an MR1 ligand that boosts anti-tumor MAIT cells. https://t.co/mr7YCGMMxh
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Excited to share our new study out in @NatureCellBio! Led by postdoc @MikeLangePhD, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. https://t.co/QBM8e07IlC
nature.com
Nature Cell Biology - Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of...
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#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembioBryan and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. https://t.co/SJG1jBWnm7
#lipidtime
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The Weintraub Award is seeking nominations for 2026! The award recognizes the outstanding achievements of grad students in biology and was established to honor the bold, creative, pioneering spirit embodied by Dr. Hal Weintraub.
fredhutch.org
Annual award to honor the bold, creative, pioneering spirit embodied by Hal Weintraub. The Harold M. Weintraub Graduate Student Award recognizes outstanding achievements during graduate studies in...
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Tumor-associated macrophages protect glioblastoma cells from ferroptosis by inducing the release of ferritin-bound iron via exosomes. https://t.co/4a7XmmO7N8
#biorxiv_cancer
biorxiv.org
Tumor-associated macrophages (TAMs) are the most abundant non-tumor cell type in glioblastoma (GBM) and act as the pivotal cell type in regulating iron metabolism in the GBM tumor microenvironment....
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Interested in organellar metabolomics? Check out my talk tomorrow on how the Rapid Organellar IP technology has enabled discoveries in organellar biology over the past 10 years! Thanks Technology Networks for the invite to present! @CRI_UTSW
technologynetworks.com
Proteomics and metabolomics are unlocking new dimensions in our understanding of biology and disease. This event will highlight the latest developments in mass spectrometry, single-cell proteomics...
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🤯 New in @Nature from @MDAndersonNews colleagues @adam_grippin @StevenLin_MDPhD SARS-CoV-2 mRNA vaccines sensitize tumors to immune checkpoint blockade https://t.co/kiZCCnf5Uw
nature.com
Nature - mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
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What did the largest trial of an early detection of cancer blood test show? https://t.co/SuSTyk23Tr
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Today @AnthropicAI released PubMed integration for Claude. No hallucinations. Just real science, real data. As a beta tester, this has been a game changer—like having a supercharged research assistant. Here are 6 prompts that will transform how you search the literature. A 🧵
We’re building tools to support research in the life sciences, from early discovery through to commercialization. With Claude for Life Sciences, we’ve added connectors to scientific tools, Skills, and new partnerships to make Claude more useful for scientific work.
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Congratulations to IICD member @bstockwell who was awarded an NCI P01 grant with Xuejun Jiang (@mskcancercenter) and Wei Gu (@columbiamed). Read more: https://t.co/Vv9WnVwSwV
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New work by @FangtaoChi from our lab on how dietary cysteine regulates intestinal stem cells via mucosal/intraepithlial CD8+ T cells. An interesting example of metabolic coupling of cysteine between crypt epithelial stem and progenitor cells and T cells.
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Our work describing the metabolic roles of serum for cancer cell proliferation is now out @jbiolchem! Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process. See here: https://t.co/vKtmAewPAG
Excited to share a new preprint, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside: A broadly applicable serum-free media, Quantitative lipid uptake characterization, Evidence lipid scavenging > synthesis for cancer cell proliferation
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Creatine fuels cancer. In @jbiolchem, we show CKB drives CK activity in NSCLC, osteosarcoma & ovarian cancer, promoting metastasis & anoikis resistance. Led by postdoc Mouna Tlili, in collaboration with Peter Siegel + @McGillGCI @McGillBiochem. Preproof:
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https://t.co/BcYfva1vrs Itaconate is metabolized to 2-hydroxymethylsuccinate through a CoA-independent degradation pathway in mitochondria
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Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @Cell_Metabolism @RockefellerUniv
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Are you attending SACNAS NDiSTEM 2025!? Don't miss this awesome session about "How to Identify the Right Mentor for You" hosted by @greisha_ortiz @Colon_Lorianna @luisci22 and @JEncarnacion_. #NDiSTEM2025 #SACNAS #STEM #STEMResearch #PLI @SACNAS @sonia__zarate @eraguilera12 🧪🔬
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I hear about this. This is not uncommon and it bothers me: Patient has cancer which is getting worse and causing pain Waits days for doctors appointment See the doctor. Scans ordered. But now waits days for an appointment slot to get the scans Scan is done and shows the
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Register for our DMRC Rising Stars event on Oct. 7 and hear from rising stars from institutions across the country. This is a multi-departmental effort, aligned with the University of Utah's synergistic approach to amplify voices and foster connections. https://t.co/tNJkOQAWpz.
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