Judith Simcox PhD
@JudithSimcox
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Associate Professor @UWBiochem studying lipid signaling and regulation | HHMI FHS | opinions are my own and do not reflect those of my employer
Madison, WI
Joined November 2018
Thrilled to have our story on the regulation of lysosomal lipids out in @Cell_Metabolism! The work was led by two outstanding grad students @_JessDavidson and Raghav Jain probing mechanistic control of energy expenditure @HHMINEWS @UWBiochem
New! Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV https://t.co/QcT4tpbNWl
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If you’re looking for an Assistant Professor position, in immunology, metabolism, and aging- come join us in Madison! The metabolism community is outstanding and spans the entire campus. https://t.co/tq7cq5sPLL
jobs.wisc.edu
Current Employees: If you are currently employed at any of the Universities of Wisconsin, log in to Workday to apply through the internal application process.Job Category:FacultyEmployment Type:Reg...
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Congrats to Postdoc Danny Son and all of our colleagues and collaborators on this paper.
Neutrophil-derived IL-1β preserves lipid stores during metabolic stress, highlighting a physiological function of innate immune cells in limiting lipid loss and maintaining energy homeostasis @Nature @UCSDMedSchool @LabSaltiel
https://t.co/5rYZMl75ft
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If you’re looking for an Assistant Professor position, in immunology, metabolism, and aging- come join us in Madison! The metabolism community is outstanding and spans the entire campus. https://t.co/tq7cq5sPLL
jobs.wisc.edu
Current Employees: If you are currently employed at any of the Universities of Wisconsin, log in to Workday to apply through the internal application process.Job Category:FacultyEmployment Type:Reg...
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Huge milestone for the McReynolds Lab! Our first preprint is out, led by senior PhD candidate Abrar Alsaadi with key contributions from visiting clinical scientist Dr. Lina Welz—my first “postdoc” when the lab was just beginning. Their work uses multi-omics + in vivo isotope
researchsquare.com
Host-microbiota metabolic interactions critically regulate nicotinamide adenine dinucleotide (NAD+) homeostasis, and their disruption is increasingly linked to chronic diseases including inflammatory...
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cell.com
Illiano et al. apply a multi-omics approach to study the effects of post-SG dietary protein on host metabolism in mice. Counter to current practice, following SG, they find that a low-protein,...
(1/4) We are excited to share our first WiSLiM manuscript! With the help of @LammingLab and @cholsoon_jang, we attempt to challenge the dogmatic approach to post-bariatric surgery diet with some surprising results... @WiscSurgery @WiscMIS @UWHealth
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1/ New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @DanNomura and huge credit to grad student superstar Sydney Tomlinson! https://t.co/CT5knDfjSM
biorxiv.org
Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously “undruggable” proteins. Current...
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We show that cerebellar microglia age differently from microglia in other brain regions, revealing unique molecular and spatial adaptations. Amazing teamwork with @HenzeDoug! Huge thanks to the @wysscoray & @StephenQuake labs and @BrainResilience! https://t.co/JXnZ7KP1d9
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Excited to finally share the main thrust of my dissertation research. Here we developed a series of new in vitro tools to ask the question: how does ATG2 function on the surface of a lipid droplet? https://t.co/CrqlvhfK7X
pnas.org
Bridge-like lipid transfer proteins (BLTPs) are established to function in phospholipid transport between bilayers at organelle–organelle contact s...
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Tenure-track Assistant Professor position in Metabolic Biology / Human Metabolic Disease @UCBerkeley! Fantastic opportunity to join an interdisciplinary department with strengths in metabolism, nutrition & human health. Please help spread the word! https://t.co/N5XJhvcw9S
jobs.sciencecareers.org
Assistant Professor - Environmental Impact on Human Metabolic Disease Position overview Position title: Assistant Professor Salary range: T
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This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins. https://t.co/X1n0OEsCeK
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@HHMINEWS Summer Undergraduate Research Experience - #CechFellows named in honor of Prof Tom Cech Deadline to apply: 12/22/2025 Spend 9 weeks in a paid, mentored biomedical research experience in an HHMI lab. See you next summer!!! https://t.co/FglNF1FdiF
hhmi.org
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
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Excited to share our latest paper led by Renata Goncalves @RenataG81952725: CoQ imbalance drives reverse electron transport to disrupt liver metabolism. https://t.co/aEEgIEAIsU We uncover how altered CoQ redox balance triggers RET and rewires hepatic metabolism to offer
nature.com
Nature - Reverse electron transport is the mechanism behind excess mitochondrial reactive oxygen species in the livers of obese mice, which has implications for developing therapeutics for fatty...
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We're looking for a Lab Manager to join our lab @arcinstitute @Stanford! Apply at https://t.co/Xpco4tMK9r
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Registration is now open for the 2026 Kern Lipid Conference on “Lipids and Lipoproteins in Cardiometabolic and Neurodegenerative Diseases”. Register now: https://t.co/WiRKBxLH3y
@kimberleydbruce @CreweLab
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Our soon to be renamed Dept. of Metabolic Biology and Nutrition is having a faculty search in the broad area of Metabolic Disease. Apply to join @apsarruda, @OlzmannLab, @gparlakgul, @Ale_Ferrari1 at the best metabolism department in the world!
aprecruit.berkeley.edu
University of California, Berkeley is hiring. Apply now!
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Can one target SLC25A51 the major determinant of the mitochondrial NAD+ pool to improve hepatocyte health and regeneration?
nature.com
Nature Metabolism - Modulating mitochondrial NAD+ levels by changing the expression of the mitochondrial NAD+ transporter, SLC25A51, Mukherjee et al. demonstrate that mitochondrial, rather than...
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Super excited to be launching Madison AI for Proteins (MAIP) with @anthonygitter ! Fun fact: the "Maip" dinosaur is one of the largest raptors to have ever lived join our mailing list and stay tuned at https://t.co/ayI7lf8W3c
.@HWaymentSteele and I are creating the Madison AI for Proteins (MAIP) group to discuss early-stage research at monthly meetups, share computational resources, and grow this local community. Visit https://t.co/QYXDwxcx3K to sign up for announcements and watch for our 2026 events.
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Calling all rising juniors & seniors: Interested in biological or biomedical research? Apply now for our ’26 Summer Undergraduate Research Experience Program! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more:
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Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency @CharlesMBrenner
nature.com
Nature Metabolism - In a mouse model of the rare disease citrin deficiency, the authors discovered that the accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction. The...
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On #WorldDiabetesDay, #NASmember E. Dale Abel reflects on a career spent uncovering how diabetes affects the heart & blood vessels, and how new research is paving the way toward prevention, earlier interventions & more equitable access to care worldwide. https://t.co/ZGroT8jtMt
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