James Olzmann
@OlzmannLab
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Professor of Molecular Therapeutics and Metabolic Biology at UC Berkeley; Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology
Berkeley, California. USA.
Joined August 2018
Excited to share our new study out in @NatureCellBio! Led by postdoc @MikeLangePhD, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. https://t.co/QBM8e07IlC
nature.com
Nature Cell Biology - Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of...
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Happy to see some of our work on #lipiddroplets and #ferroptosis finally out! We reveal opposing roles for LDs in ferroptosis - protection vs. sensitization - balancing membrane and mitochondrial homeostasis with LD-localized lipid oxidation.
biorxiv.org
Lipid droplets (LDs) are dynamic fat storage organelles involved in fatty acid metabolism, signalling and trafficking. By storing polyunsaturated fatty acids (PUFAs) in the form of neutral lipids,...
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Miami did not disappoint! From cold plunges to cool drinks, we took that LIVE. FIT. GO. lifestyle to a whole new level to celebrate the release of our Limited Edition Spritz Vibe Snowball Frost!
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Lipid Droplet quality control #Ferroptosis "LD-localized FSP1/ferroptosis suppressor protein 1 reduces CoQ10 to generate local antioxidants that prevent neutral lipid peroxidation (+ ferroptosis)" "ferroptosis can also be triggered from LDs", in addition to ER or lysosome
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New paper in @ScienceMagazine identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors! https://t.co/xSmNywS9PW
science.org
The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the...
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Too many men die of prostate cancer. We miss you John. We discovered a new way of attacking androgen receptor driven prostate cancers that will lead to new therapeutics. This was a wonderful collaboration with @li_haolong and Felix Feng (rest in peace). https://t.co/24bBKLdWus
nature.com
Nature Genetics - Genome-wide CRISPRi screens for modulators of androgen receptor (AR) protein levels using live-cell quantitative endogenous AR fluorescence reporters identify PTGES3 as a new...
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Two new Nature papers show that inhibiting FSP1 is sufficient to restrict tumor growth in vivo, a major step forward for ferroptosis-targeted cancer therapy. Huge congrats to all authors! https://t.co/ezDfPzSqvK
https://t.co/uaYWXKoi87
#Ferroptosis #FSP1 #CancerResearch
nature.com
Nature - The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung...
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Induced proximity-based therapeutic modalities https://t.co/hzBGTQEVyt
https://t.co/Y7toX848yE This new Review discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
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Curious how proteins find their way to #LipidDroplets? Our bipartite review traces their journey from ER insertion to LD partitioning: 👉 Navigating lipid droplet proteins - part I: ER targeting routes of LD-destined membrane proteins https://t.co/kPAlaFtYPg
portlandpress.com
Lipid droplets (LDs) are cytosolic lipid storage organelles that derive from the endoplasmic reticulum (ER). Their biogenesis and function are essential for maintaining cellular lipid homeostasis and...
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Curious how proteins find their way to #LipidDroplets? Our bipartite review traces their journey from ER insertion to LD partitioning: 👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning https://t.co/OPxIuiPLkK
portlandpress.com
Lipid droplets (LDs) originate from the endoplasmic reticulum (ER) and are unique among cellular organelles, as they consist of a hydrophobic core of neutral lipids that is surrounded by a phosphol...
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Earlier this month, a celebratory toast welcomed Professor Omar Yaghi back to campus in honor of his Nobel Prize in Chemistry. The afternoon's images continue to inspire, long after the celebration ended.
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Excited to share our review on Induced Proximity-based therapeutic modalities now out in Nature Reviews Drug Discovery!
nature.com
Nature Reviews Drug Discovery - Induced proximity modalities encompass monovalent and bifunctional agents, such as molecular glues and proteolysis-targeting chimeras, that induce an interaction...
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Looking forward to giving a talk today at @WashU about our latest research at the 2025 Academic Drug Discovery Colloqium!
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You can unleash your creativity on our HALODISC — treat it like a canvas and give your car a pair of truly one-of-a-kind shoes!
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#ACSChemBio and #Biochemistry invite submissions to a special issue on Lipids and Lipidation guest edited by @chembioBryan and me! Find details in the #CallforPapers and submit your exciting findings to one of these journals by May 31, 2026. https://t.co/SJG1jBWnm7
#lipidtime
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🚀 Excited to share our latest @biorxivpreprint by @CEStieger We unveil TRACERs - Transcriptional Regulation via Active Control of Epigenetic Reprogramming - a new small-molecule-based induced-proximity modality that silences transcription factors by recruiting endogenous
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Congratulations to senior authors Gokul Upadhyayula and Rui Gao and co-first authors Wei Wang @UIC and Gaoxiang Liu + Xiongtao Ruan @ABCUCBerkeley on imaging axons and myelin sheaths across the entire mouse olfactory bulb in wild type and diseased states. This certainly
biorxiv.org
Understanding biological systems requires observing features and processes across vast spatial and temporal scales, spanning nanometers to centimeters and milliseconds to days, often using multiple...
Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → axons & myelin across mouse olfactory bulbs (WT vs NPC1).
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Congrats to MCB's Professor (Affiliated) Daniel Fletcher on his election to the National Academy of Medicine! 🎉👏
Congratulations and welcome to the 100 new members elected today to the National Academy of Medicine! #NAMmtg
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Assistant Professor faculty position at @UCBerkeley focusing on metabolic disease. 🤩 https://t.co/vV96QoZCwZ
aprecruit.berkeley.edu
University of California, Berkeley is hiring. Apply now!
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An absolute privilege and joy to work with this exceptional group of scientists at @UCBerkeley. ☺️#NewLabPhoto
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Who says crypto has to be complicated? Meet our cutest educators yet: Cross River kids! They're helping us explore crypto concepts with clarity, curiosity, and a lot of charm! Watch the video to learn from the experts!
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Reminder 🎗️Applications due 10/20/25!
We're Hiring! Assistant Professor of Molecular Therapeutics in MCB. Learn more and apply online: https://t.co/AifKRI8fbl
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Happy to have contributed in a small way to this exciting story from Fangzhu Zhao and @realJimWells now out in @J_A_C_S. "Hijacking Extracellular Targeted Protein Degrader–Drug Conjugates for Enhanced Drug Delivery" https://t.co/WTuIi5Qdg9
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