Omer Yilmaz
@ohyilmaz
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Gastrointestinal pathologist, stem cell biologist, cancer researcher at MIT and Harvard, University of Michigan alumnus
Joined May 2009
Ultra-Processed Foods with probable link to ⬆️ risk of young-onset #colorectalcancer 📣 Foods to avoid: mass production breads, cereals, box soups, frozen meals, 🍪, many packaged groceries with a long shelf life.
healthline.com
Women under 50 whose diets include a lot of ultra-processed foods have a significantly increased risk of developing polyps that can progress into colorectal cancer, a new study warns.
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This study shows how re-thinking platinum chemistry can make existing treatments stronger and smarter. Proud of our collaboration across MIT, URI, UC Berkeley, and Harvard. Fang Wang, Jon Braverman, George Eng, Mike Hemann lab/MIT, and Stephen Lippard/MIT
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These new platinum-based drug conjugates stop cancer cells from pumping drugs out — a key reason many tumors stop responding to therapy. In lab and organoid models of colon cancer, this approach delayed resistance and improved survival in mice.
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Our team designed a “dual-warhead” drug that links platinum to doxorubicin to tackle one of cancer’s toughest problems — chemoresistance. It keeps chemo inside cancer cells longer and boosts effectiveness. 🔗
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This "over-WNTing" approach offers a potential treatment avenue that works by hyperactivating the very pathway driving colorectal cancer, turning the tumor's fundamental dependence into a liability.
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The therapeutic efficacy extends across the full disease spectrum. We demonstrate effectiveness in early adenomas, advanced mouse models, and critically, patient-derived metastatic tumors. We've also developed a nanoparticle formulation for GSK3 inhibitor delivery.
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Through systematic screening in organoid models, we identified multiple approaches to hyperactivate WNT signaling—GSK3 inhibition or concentrated WNT proteins. All selectively induced tumor cell death while sparing normal tissue.
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Important findings from our lab on colorectal cancer therapy. George Eng shows that APC-mutant tumors maintain a precise WNT signaling threshold. Driving activation beyond this point creates a selective therapeutic window. Preprint:
biorxiv.org
WNT signaling maintains intestinal homeostasis yet drives colorectal cancer (CRC) when constitutively activated by APC mutations. We overturn the fundamental assumption that APC-mutant tumors exist...
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#NatMetabPicks | In @Nature led by @ohyilmaz (@kochinstitute) Coupled cysteine metabolism between intestinal stem cells and mucosal CD8αβ+ T cells increases intestinal stemness. https://t.co/9pJb9Ul03l
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New work by @FangtaoChi from our lab on how dietary cysteine regulates intestinal stem cells via mucosal/intraepithlial CD8+ T cells. An interesting example of metabolic coupling of cysteine between crypt epithelial stem and progenitor cells and T cells.
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For the #organoid research group that I founded at the Princess Máxima Center, we are looking for a motivated postdoc with experience in gene editing and bioinformatics. Contact Karin Sanders (k.sanders@prinsesmaximacentrum.nl) to learn more. @prinsesmaximac
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AI carries forward the diagnostic thresholds of the pathologists who trained it.
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Great visit to my hometown of Cermik, Diyarbakir, Turkiye in front of Haburman Bridge
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The power of a bipartisan America—that refuses to dismantle science, cares about patients, and understands that medical academic research is also an economic engine. Thank you to the senators who stood up for NIH and the future of American health. https://t.co/DIkuPFg2pO.
science.org
Republicans on spending committee push back against proposed reorganization and overhead cuts
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Excellent obituary summarizing the contributions of Dr Till's foundational work in defining the hematopoietic hierarchy in Experimental Hematology @ISEHSociety
https://t.co/jdQXrw0EgF
exphem.org
It has been 64 years since the publication of the classic 1961 Till & McCulloch paper that described spleen colonies in lethally irradiated mice following a bone marrow transplant [1]. On May 18,...
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