Lucas Sullivan
@LucasBSullivan
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Associate professor @fredhutch & @UW. Studying metabolic constraints of cancer cell proliferation. On a mote of dust suspended in a sunbeam.
Seattle, WA
Joined March 2012
Fred Hutch's Human Biology Division is recruiting a tenure-track Assistant or Associate Professor to lead a laboratory-based research program focused on the biological mechanisms of solid tumor cancers and their clinical translation. Learn more and apply: https://t.co/7abt8x92wu
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Our work describing the metabolic roles of serum for cancer cell proliferation is now out @jbiolchem! Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process. See here: https://t.co/vKtmAewPAG
Excited to share a new preprint, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside: A broadly applicable serum-free media, Quantitative lipid uptake characterization, Evidence lipid scavenging > synthesis for cancer cell proliferation
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Check out this great interview with a true rising star in metabolism research (and lab alumni)! 🙌
#MetabolismMondays Meet Anna Vigil, #PhD student in Crocker lab @embl, @LucasBSullivan lab @fredhutch alumni sharing her work on how #metabolism impacts cell fate, development & #evolution in #Drosophila. #theNodeCorrespondents #ecr @the_Node #DevBio 👉🏽 https://t.co/jhsbMqOyQn
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Niemi lab grad student Hannah Pletcher recently joined @preLights and wrote up a nice highlight of recent work from @LucasBSullivan - check it out here!
prelights.biologists.com
Not all aspartate limitation is created equal: An aspartate biosensor reveals that inhibiting succinate dehydrogenase results in defects in pyrimidine synthesis and replication stress, unique from...
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We are excited to announce our 2025 @UofUDMRC Postdoctoral Rising Stars in Metabolism Symposium! This is truly a unique opportunity to network, present your research, and enjoy the breathtaking views that Salt Lake City has to offer. Deadline is May 15th, 2025. Please share!
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Our latest work, led by @__btjackson and Angela Montero @MSKCancerCenter demonstrates how intracellular metabolic gradients induce dependence on exogenous pyruvate in embryonic stem cells
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Congratulations to @AKesarwala Emory SOM and all awardees on receiving the Keystone Tumor Metabolism Awards and for their exciting advancement of the field!
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Hello everyone! I am helping to organize a one-day symposium on fluorescent metabolite biosensors and their use in metabolism research. It will be May 12-13 and associated with the Cold Spring Harbor Laboratory “Mechanisms of Metabolic Signaling” Symposium. Our field needs to be
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Check out the full "___torial" at: https://t.co/DMCCR6V8DZ
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Next, our 2nd preprint of the week(!), this one driven by @madelouhart. Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability. Here: we track the kinetics of ASP depletion/ proliferation impairments and..surprises ensue!
Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis https://t.co/p8LOUdCZbf
#biorxiv_cellbio
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For more commentary about the manuscript, come see our post over on the "other" website. 🦋
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Excited to share a new preprint, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside: A broadly applicable serum-free media, Quantitative lipid uptake characterization, Evidence lipid scavenging > synthesis for cancer cell proliferation
Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation https://t.co/25sxNYLvdK
#biorxiv_cancer
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An award at the @fredhutch pumpkin carving contest might be my lab’s crowning achievement. Tough competition! The team had the great idea to do a live, pumpkin-based demonstration of how a triple quad MS works (with fragmentation) 😂
So many phenomenal pumpkins at this year’s carving contest! Congratulations to the @HarmitMalik Lab for most humorous, the Talbot Lab for most horrific, the @MelodyGCampbell Lab for most artistic, and the @LucasBSullivan Lab for most scientific!
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Very proud to share that my postdoc work from @mvhlab is now published @NatMetabolism! 📢 https://t.co/JLiWoHSATY See below for details…
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🚨We are hiring! Tenure-track faculty position (Assistant Professor) in the area of cancer metabolism, diet, tumor-host interactions. Apply below 👇 https://t.co/GiNGLor6Lz
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This work was driven by PhD student Kristian Davidsen and built off prior protocols established by others (esp. T Pan and D Nedialkova labs). If you are interested in this approach for your research, check out the improvements described here and detailed protocol in Supp File 2!
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Our latest work just came out in its final VOR form @eLife, wherein we describe our efforts to optimize sequencing-based measurements of tRNA aminoacylation using tRNA-seq, via improvements to RNA stability, ligation efficiency, and data processing. https://t.co/QPmN463l8S
elifesciences.org
Improved chemical, molecular biology, and computational approaches establish an optimized method for accurate and precise quantification of tRNA expression, modifications, and aminoacylation.
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Check out our Spotlight article, written by grad student David Sokolov, highlighting two excellent papers describing purine salvage as an important metabolic resource for tissues and tumors. Impressive work from @RJDLab, Min Ni, and @Gerta_Hoxhaj labs! https://t.co/ECxYSaZPwO
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So proud of our work (@BrianTDo1 and @mvh_lab) exploring how nucleotide metabolism can impact cell fate which is now @Dev_Cell. This was a fascinating and rewarding journey that started in metabolism and led us far afield (plus add in a pandemic and my move @UMich).
Online now: Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
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