Lucas Sullivan
@LucasBSullivan
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Associate professor @fredhutch & @UW. Studying metabolic constraints of cancer cell proliferation. On a mote of dust suspended in a sunbeam.
Seattle, WA
Joined March 2012
Check out this great interview with a true rising star in metabolism research (and lab alumni)! š.
#MetabolismMondays.Meet Anna Vigil, #PhD student in Crocker lab @embl, @LucasBSullivan lab @fredhutch alumni sharing her work on how #metabolism impacts cell fate, development & #evolution in #Drosophila. #theNodeCorrespondents #ecr @the_Node #DevBio . šš½
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RT @nieminm: Niemi lab grad student Hannah Pletcher recently joined @preLights and wrote up a nice highlight of recent work from @LucasBSulā¦.
prelights.biologists.com
Not all aspartate limitation is created equal: An aspartate biosensor reveals that inhibiting succinate dehydrogenase results in defects in pyrimidine synthesis and replication stress, unique from...
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RT @RutterLab: We are excited to announce our 2025 @UofUDMRC Postdoctoral Rising Stars in Metabolism Symposium! This is truly a unique oppoā¦.
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RT @lydfinley: Our latest work, led by @__btjackson and Angela Montero @MSKCancerCenter demonstrates how intracellular metabolic gradientsā¦.
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RT @shanmugamlab: Congratulations to ā¦@AKesarwalaā© Emory SOM and all awardees on receiving the Keystone Tumor Metabolism Awards and for theā¦.
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RT @RutterLab: Hello everyone! I am helping to organize a one-day symposium on fluorescent metabolite biosensors and their use in metabolisā¦.
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Next, our 2nd preprint of the week(!), this one driven by.@madelouhart. Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability. Here: we track the kinetics of ASP depletion/ proliferation impairments and. surprises ensue!.
Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis #biorxiv_cellbio.
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For more commentary about the manuscript, come see our post over on the "other" website. š¦.
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Excited to share a new preprint, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:.A broadly applicable serum-free media, .Quantitative lipid uptake characterization, .Evidence lipid scavenging > synthesis for cancer cell proliferation.
Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation #biorxiv_cancer.
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An award at the @fredhutch pumpkin carving contest might be my labās crowning achievement. Tough competition! The team had the great idea to do a live, pumpkin-based demonstration of how a triple quad MS works (with fragmentation) š.
So many phenomenal pumpkins at this yearās carving contest! .Congratulations to the @HarmitMalik Lab for most humorous, the Talbot Lab for most horrific, the @MelodyGCampbell Lab for most artistic, and the @LucasBSullivan Lab for most scientific!
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RT @sharanya_siva: Very proud to share that my postdoc work from @mvhlab is now published @NatMetabolism! š¢See beloā¦.
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RT @dbezwada: Glad to finally see this paper online. Using observations in humans and functional data in mice, we demonstrate that mitochonā¦.
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RT @LabDeNicola: šØWe are hiring! Tenure-track faculty position (Assistant Professor) in the area of cancer metabolism, diet, tumor-host intā¦.
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This work was driven by PhD student Kristian Davidsen and built off prior protocols established by others (esp. T Pan and D Nedialkova labs). If you are interested in this approach for your research, check out the improvements described here and detailed protocol in Supp File 2!.
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Our latest work just came out in its final VOR form @eLife, wherein we describe our efforts to optimize sequencing-based measurements of tRNA aminoacylation using tRNA-seq, via improvements to RNA stability, ligation efficiency, and data processing.
elifesciences.org
Improved chemical, molecular biology, and computational approaches establish an optimized method for accurate and precise quantification of tRNA expression, modifications, and aminoacylation.
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Check out our Spotlight article, written by grad student David Sokolov, highlighting two excellent papers describing purine salvage as an important metabolic resource for tissues and tumors. Impressive work from @RJDLab, Min Ni, and @Gerta_Hoxhaj labs! .
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RT @PeggyPHsu: So proud of our work (@BrianTDo1 and @mvh_lab) exploring how nucleotide metabolism can impact cell fate which is now @Dev_Ceā¦.
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The final 'VOR' for our aspartate sensor manuscript has now been published after peer review @eLife. Updates include additional sensor characterization and demonstration of response to aspartate restoration in cells. Thanks to the editors and reviewers!.
I am pleased to share our latest preprint, led by @HHMIjanelia's Jonathan Marvin and PhD student Kristian Davidsen, where we engineer and implement a biosensor (jAspSnFR3) enabling dynamic measurements of the amino acid aspartate (ASP):.
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RT @erin_liuxiaolei: Big thanks to David Sokolov and @LucasBSullivan @fredhutch & @UW for their insightful highlight on a recent Cell paperā¦.
academic.oup.com
In addition to their canonical roles in biosynthetic pathways, metabolites can be active participants in oncogenic signalling, but our understanding of the
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