Pagliarini Lab
@Pagliarini_Lab
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Mitochondrial systems biochemistry
HHMI/WashU School of Medicine
Joined March 2015
Bullseye! Nobel Prizes This Year Offer Three Cheers for Slow Science
nytimes.com
The scientific Nobels announced this week — in Physiology or Medicine, Physics and Chemistry — honored achievements rooted in fundamental research from decades ago.
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Registration is open (and free) for this year's Midwest Metabolism/Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) Annual Conference at the University of Michigan November 10–11, 2025. Hope to see you there! https://t.co/78aHpvoTkN
vai.org
Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.
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Very proud of the hard work and resilience by @EdreesRashan, @AbbyBartlett_ and many others on this work!
As promised, a 🧵 on our recent article now out in @NatureSMB! Co-led with @AbbyBartlett_ @Pagliarini_Lab @JudithSimcox, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯#lipidtime
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AHH!! My primary thesis work is finally out! Tweetorial to come...
New online! ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism https://t.co/JxDn3pT7lW
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The countdown to #ASBMB25 is on! Visit our annual meeting website to start adding special sessions, keynote lectures, scientific symposia and more to your personal schedule. Plus, check out these other opportunities for scientists: https://t.co/jxvt99rEU5.
asbmb.org
Visit our #ASBMB25 website to start adding special sessions, keynote lectures, scientific symposia and more to your personal schedule.
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ATTENTION #Mito Sci-Med Community: Abstracts for #MitoMed 2025 in St. Louis are due on March 31. Submit your abstract here: https://t.co/38pPKMXNpS Scholarship applications are available on https://t.co/huz6q66QYE
#mitoresearch #mitomedicine @mitowomen
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NIH cuts are hitting young scientists the hardest. By David Baker.
timmermanreport.com
[Editor’s note: David Baker gave this speech to Seattle community leaders Mar. 10, at a celebration of his 2024 Nobel Prize in Chemistry.] Let me just briefly tell you how innovation arises in...
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🚨New preprint available! Third and final in the #CRISPR screen series!🚨 👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis https://t.co/0E8dKqdhpw By A. Strefeler in collaboration with @Pagliarini_Lab Please RT 🙏🏻 🧵1/9
biorxiv.org
Nucleotides are essential for nucleic acid synthesis, signaling, and metabolism, and can be synthesized de novo or through salvage. Rapidly proliferating cells require large amounts of nucleotides,...
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🚨 New paper alert! 🚨 Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with @MazeInBiotech 🔗 Paper: https://t.co/21dGI0ebhX
@CellCellPress
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💫NEW: @Zak_Bakes @Pagliarini_Lab & co show that #mitochondria stress recovery requires mobilization of #LipidDroplet triacylglycerol stores to facilitate #cardiolipin biosynthesis and mitochondrial biogenesis. https://t.co/iXVm50aNOm
nature.com
Nature Cell Biology - Baker et al. show that mitochondrial stress recovery requires mobilization of lipid droplet triacylglycerol stores to facilitate cardiolipin biosynthesis and mitochondrial...
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Join us for the @UMDF Mito Med 2025 meeting this July in St. Louis! Abstract submissions due 3/31. Multiple SciMed Scholarships are being offered this year. See links below! https://t.co/MhiCJSQ8AX
https://t.co/B3Gr7qihzh
https://t.co/8UzcJu6OEQ
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#ASBMB25 is an opportunity to immerse yourself in the forefront of science, exchange groundbreaking ideas, and spark collaborations that could change everything. 🔬You can register and submit your late-breaking abstracts here: https://t.co/UwgMdxBo15.
asbmb.org
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Excited to co-chair #ASBMB2025 with the incredible @Pagliarini_Lab! This year’s @ASBMB meeting promises to showcase cutting-edge science, foster dynamic collaborations, & inspire new ideas. Don’t miss your chance to be part of it—register & submit your late breaking abstracts!🔬
#ASBMB25 is an opportunity to immerse yourself in the forefront of science, exchange groundbreaking ideas, and spark collaborations that could change everything. 🔬You can register and submit your late-breaking abstracts here: https://t.co/UwgMdxBo15.
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I'm excited to share our latest work linking TAG mobilization to mitochondrial stress recovery. A monumental effort by @Zak_Bakes (on the faculty job market soon!). Great collaboration with the @Coon_Labs and others. https://t.co/4gnU2DgaG4
#mitochondria
#HHMINews
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HHMI Investigator Nels Elde (@ElEarlyBird) of @UUtah works at the crossroads of evolutionary genetics and cell biology to study one of the biggest battlefronts in science: host-pathogen interactions. Learn more about the Elde lab’s research: https://t.co/NRXQcKqLjV
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@Pagliarini_Lab we are looking forward to your presentation at #Mito25 this coming February☀️There is only 2 WEEKS left to register, so please RT to let your followers know limited spaces remain to join us in the Dominican Republic! 🇩🇴 Register here➡️ https://t.co/FXKLax00Cg
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Interested in building small molecule screening and/or genetic assay systems for exploring new mitochondrial biology and therapeutics? See our HHMI posting for a Research Specialist II position. https://t.co/WFfZSLkcaP
#HHMI
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Meet our #MitoMed 2025 Planning Committee! Save the Date for our UMDF Mitochondrial Medicine Conference in St. Louis, June 18-21, 2025. Learn more at https://t.co/huz6q66QYE
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we are excited to share our latest work on mapping and exploiting conditional drug sensitivity in cancer cells @ScienceAdvances! next chapter of unbiased profiling in #HPLM as a source of new insights! congrats to co-1st @kyle_flickinger and Kelli Wilson!
science.org
Chemical screens identify drug sensitivities that vary in conventional versus Human Plasma–Like Medium (HPLM).
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Great as always to work with @taylorlabncl and @MitoMonika! Another interesting example of coordinated coenzyme Q biosynthesis and complex I assembly.
Excited to share our latest preprint, led by @MitoMonika Rachel Guerra & @mitocollier in collaboration with the Wittig lab & @Pagliarini_Lab
https://t.co/PnFtk6HlFT
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