Children’s Research Institute at UT Southwestern
@CRI_UTSW
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Interdisciplinary, collaborative researchers seeking #RelentlessDiscovery toward treatments of tomorrow. #regeneration #StemCells #CancerBiology #Metabolism
Dallas, Texas, USA
Joined August 2015
Discover Prashant Mishra’s, M.D., Ph.D., work at @CRI_UTSW, where he studies mitochondria to tackle common genetic disorders. His research aims to unlock new therapies and tools to improve patient care. Learn more: https://t.co/ulqoUeTJQI
#MeetTheMinds
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Fantastic @Fusion_conf on retrotransposons #EREHD25 and redox #RedoxBio25 concluded with two “Best Poster Awards” to our own @thechuan3 @UTSWmstp @JianXuLab @StJude and @DohunKim96 and @Gerta_Hoxhaj lab @CRI_UTSW. Congratulations to Michael and Dohun!
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@CRI_UTSW continues pushing the boundaries of science and inspiring the scientific community worldwide! Check out two new publications from the DeBerardinis and @Zhu_Lab labs, published this week in @ScienceMagazine. @UTSWMedCenter @ScienceNews @UTSWScience
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ONLINE NOW in @ScienceMagazine: Zhu Lab discovers location matters for liver cancer's origins. Read more ➡️ https://t.co/0wB41Dr3GR 🔖 @Zhu_Lab breakdown ⬇️ #relentlessdiscovery @ScienceNews
cri.utsw.edu
Hepatocellular carcinoma arises primarily in zone 3 due to glutathione transferase genes that help mutated cells avoid dying Scientists have discovered liver cancers arise in specific metabolic...
Where do cancers start? In the liver, not all cells are the same. The liver is divided into 3 “zones,” and each specializes in different metabolic tasks. We show in @Science that where a mutation occurs in a liver lobule can determine a cell’s fate. https://t.co/3YTc77gZcd (1/9)
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🔖 Ralph's full breakdown: https://t.co/BnB7lBvnIA
#relentlessdiscovery @ScienceNews @ScienceMagazine
ONLINE NOW in @ScienceMagazine: CRI DeBerardini's Lab discovers protein regulating balance between purine nucleotide production pathways, read more ⬇️ https://t.co/wAAD1esTgc
#relentlentlessdiscovery @ScienceNews
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ONLINE NOW in @ScienceMagazine: CRI DeBerardini's Lab discovers protein regulating balance between purine nucleotide production pathways, read more ⬇️ https://t.co/wAAD1esTgc
#relentlentlessdiscovery @ScienceNews
cri.utsw.edu
NUDT5 suppresses de novo purine biosynthesis through PPAT interaction, affects thiopurine sensitivity The protein NUDT5 is a vital regulator of how cells build purine nucleotides, which may determine...
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6 years ago, Lizz took a leap of faith by moving across the country to join our new/empty lab as a research tech. She then became our 1st grad student, playing a big role in shaping our research directions and lab culture. Today she defended her PhD, and I couldn’t be more proud.
Defended! 🍾 Introducing Elizabeth Maurais, Ph.D. 🎉 Congrats on your successful #dissertationdefense. Dr. Maurais was joined by her mentor @PeterLyLab & other Ly Lab mates. Next stop: #postdoc!
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Defended! 🍾 Introducing Elizabeth Maurais, Ph.D. 🎉 Congrats on your successful #dissertationdefense. Dr. Maurais was joined by her mentor @PeterLyLab & other Ly Lab mates. Next stop: #postdoc!
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👋👋 Hi @SihanSean, 👋👋 hi @stanleylim93 😍 love seeing CRI researchers out in the wild, spreading the #relentlessdiscovery! 🌺 #ecDNA25
Wonderful conference organized by @zz_zhaozhang @regenberg_lab @Fusion_Conf. Congrats to @stanleylim93 for the #1 best poster. And PI got awarded for his nosiness on other people’s research. Photo credits to @PeterLyLab
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Happy Halloween 🎃 Scary: food in the lab (@harrison__tom) Sweet: problem-solving lab managers, like Jessica! 🎃🍬🤍🦇🕷️🕸️🐈⬛💀🧡🐦⬛🕯️🖤🍂🍁🔮
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ONLINE NOW: CRI's Ohlstein Lab presents new research that reevaluates whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila, in @PNASNews. Read more ⬇️ https://t.co/HzUPt1jjqN
#relentlessdiscovery
pnas.org
Recent work suggests that asymmetric segregation of preexisting and newly synthesized canonical histone 3.1 (H3.1), but not variant histone 3.3A (H...
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👋👋 @TrevorTippetts1! Great to see CRI postdocs spreading the wealth of knowledge. #relentlessdiscovery
Such an inspiring day leading a session for the STEM Career Exploration Program hosted by the @UTSWMedCenter STARS program. Proud of our team’s dedication to giving back and sparking scientific curiosity in the leaders of tomorrow. @RTPatUTSW @UTSWGradSchool @UTSWmstp @utswstars
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📍#MotivationMonday: "Resilience isn’t something that you are born with – it is a set of skills you have to cultivate.” -@SJMorrison_ Read more about pushing through adversity & #relentlessdiscovery with Sean & Ralph ⬇️ https://t.co/s0xHV4f9fe
utsouthwestern.edu
Four distinguished UT Southwestern scientists who are members of the National Academies inspired postdoctoral researchers by sharing their own experiences as postdocs recently, offering words of...
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Good news: CRI's @MishraLab & @Zhu_Lab have been selected to develop in vivo genetic screens to identify new regulators of liver #trauma. It's another example of CRI's #relentlessdiscovery toward the treatments of tomorrow. @UT_TRC4
TRC4 News: "TRC4 AWARDS $18M IN SECOND ROUND OF GRANT FUNDING FOR TRAUMA CARE RESEARCH" TRC4 an initiative of the @utsystem, today announced a new round of grant awards totaling $18M to fund research and product development. READ FULL RELEASE: https://t.co/z6N4ioxSuX
#txlege
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Interested in organellar metabolomics? Check out my talk tomorrow on how the Rapid Organellar IP technology has enabled discoveries in organellar biology over the past 10 years! Thanks Technology Networks for the invite to present! @CRI_UTSW
technologynetworks.com
Proteomics and metabolomics are unlocking new dimensions in our understanding of biology and disease. This event will highlight the latest developments in mass spectrometry, single-cell proteomics...
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It’s been one week since returning from the @WeillInstitute Emerging Scholars Symposium at Cornell — three days of inspiring science, conversations, and connection. Honored to share my work and bring new ideas back to @CRI_UTSW ! 🧪🧫🧬
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Great opportunity to hear CRI's @JaviGBermudez and his recent #relentlessdiscovery ⬇️
🗽Save the date! March 24, 2026 Cancer Metabolism and Signaling Symposium @NYASciences co-organized by @LyssiotisLab @RichPossemato Speakers: @lab_manning @bensahralab @MarcusDGon @airdlab @KanarekNaama @JaviGBermudez @SantoshVardhana Josh R, Erika P +short talks from abstracts!
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Thrilled to announce the launch of my lab @CRI_UTSW this January! We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
We're growing! Our newest Investigator @Henry_de_belly will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ https://t.co/lHKW4u05xP and 📌apply to research in his lab https://t.co/fX7rO4zlwS
#relentlessdiscovery
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We are so excited for Henry to join CRI's Tissue Regeneration Program. His lab is going to study how cell shape, movement, and membrane dynamics influences regeneration and disease.
We're growing! Our newest Investigator @Henry_de_belly will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ https://t.co/lHKW4u05xP and 📌apply to research in his lab https://t.co/fX7rO4zlwS
#relentlessdiscovery
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We're growing! Our newest Investigator @Henry_de_belly will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ https://t.co/lHKW4u05xP and 📌apply to research in his lab https://t.co/fX7rO4zlwS
#relentlessdiscovery
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