Emmeran Le Moal
@ELM_ELM_ELM_ELM
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Senior scientist in the Blau lab @Stanford
Joined January 2018
Absolutely thrilled to share our last paper in @ScienceTM @BentzingerLab with amazing collaborators @DumontN_Lab and @FeigeLab and many more. A massive team effort supported by @StemCellNetwork
science.org
Apelin-13 treatment ameliorates vascular defects associated with skeletal muscle stem cell dysfunction in mouse models of muscular dystrophy.
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Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia @andygraziani
nature.com
Nature Metabolism - Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in...
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Just out - our major review piece @ImmunityCP , summarizing couple of decades of the research on human immune aging and providing highlights of the latest advances in the field. Led by Marina Terekhova, truly encyclopedic depth (327 references) https://t.co/4SenJ8VTOj
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New preprint 🔥 showing that blocking JAK1/2 with ruxolitinib boosts food intake, preserves fat, and extends survival in lung cancer–associated cachexia. @eze_dantas
https://t.co/n9FER7D3C9
#CancerMetabolism #Cachexia #LungCancer #JAKSTAT
biorxiv.org
Lung cancer is the leading cause of cancer-related death and is frequently accompanied by reduced food intake and cachexia, a debilitating syndrome characterized by weight loss and skeletal muscle...
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Epigenetic editing opens new opportunities for programming T cells. CRISPRoff can also be combined with genome editing approaches to enable new cell engineering approaches. Congratulations to @LaineGoudy and everyone involved! https://t.co/MgkM5Xa3jn
nature.com
Nature Biotechnology - Multiplexed editing in primary human T cells generates enhanced immune cell therapies.
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#Duchenne News: Today, Satellos announced that the first patient has been dosed in LT-001, an open-label, long-term follow-up study of SAT-3247 in adult males with Duchenne muscular dystrophy. Full details here: https://t.co/QziVxknqqV
#MuscleRegeneration $MSCL $MSCLF
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Excited to share some work that came out of my lab when I was at UCSF. Thanks to @UCSFstemcell @UCSFOrtho and @calico, We studied cellular dynamics and trajectories through single cell RNA Seq, heteromotility analysis and Cell Painting, to identify key regulators of stem cell
biorxiv.org
For efficient regeneration, muscle stem cells (MuSCs) transition out of quiescence through a series of progressively more activated states. During MuSC aging, transition through the earliest steps is...
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💊 Not a very good news for Medical LLMs. A new Mass General Brigham study shows leading LLMs often try to please the user in medical chats, and to do that, can output wrong advice. Paper shows that default models will confidently echo bad medical assumptions, and that a small
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Does muscle remember disuse muscle wasting? Our new pre-print just out shows skeletal muscle retains a molecular memory of disuse! Young muscle shows transcriptional resilience to repeated atrophy Aged muscle shows exaggerated susceptibility https://t.co/T0SsBXLYMk
biorxiv.org
Disuse-induced muscle atrophy is common after illness, injury, or falls, and becomes increasingly frequent with ageing. However, whether skeletal muscle retains a “memory” of disuse remains unknown....
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New in Nature Reviews Genetics: my Review on how advanced genomic technologies are redefining cellular reprogramming: mapping trajectories, dissecting chromatin dynamics, + lineage tracing & synthetic circuits to push the boundaries of cell identity. https://t.co/8NBM5ohxkJ
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New @NatureComms paper: Nuclear entry of AS160 as a transcriptional regulator of satellite cells for muscle regeneration.
nature.com
Nature Communications - The mechanisms resulting in muscle satellite cell dysfunction in diabetes are not well understood. Here, the authors show that AS160 functions in the nucleus to regulate...
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Thrilled to share my PhD work in Rawlins lab “Hypoxia promotes airway differentiation in the human lung epithelium” (10.1016/j.stem.2025.09.007), now online in Cell Stem Cell! Huge thanks to my mentor @LabRawlins and all my collaborators for their strong support!
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Translational progress in the development of pharmacotherapies for Duchenne muscular dystrophy https://t.co/BHPuBCollA
@GordonSLynch
tandfonline.com
Despite the discovery, nearly 40 years ago, that mutations in the dystrophin gene were responsible for Duchenne muscular dystrophy (DMD), a cure for this devastating disease remains elusive. Consid...
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B cells promote atrial fibrillation via autoantibodies @NatureCVR @harvardmed @MatthiasNahrend @MaartenHulsmans @PabelSteffen 🇺🇸🇩🇪 https://t.co/XUrwxnUY48
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Day Two of Frontiers In Myogenesis! Breakfast is now available until 9:00AM in the Homestead Building, followed by our first session, "Muscle Formation and Development." Today's agenda is attached below.
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"Isolation of functional lysosomes from skeletal muscle" is now in press. Check it oput at: https://t.co/YM22r7V7WB
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Excited to share our work with @DMSabatini & @JswLab. How do lysosomes change with age? We present a metabolic atlas of lysosomal aging, and reveal a lysosomal “aging clock” of metabolites linked to lysosomal storage disorders. Grateful to all co-authors! https://t.co/HyP6zq3Ccq
biorxiv.org
Lysosomal dysfunction is a well-recognized feature of aging, yet its systematic molecular investigation remains limited. Here, we employ a suite of tools for rapid lysosomal isolation to construct a...
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Very proud to share our latest manuscript in @PNASNexus! In this work, former @UMBME star student @benjy_yang asked how manipulating nuclear lamina impacted cellular reprogramming kinetics. Thank you @hevolution_f for funding! https://t.co/Dy8MBH7YCX
academic.oup.com
Abstract. Somatic cell fate is an outcome set by the activities of specific transcription factors and the chromatin landscape and is maintained by gene sil
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Bimagrumab exits stage left as the healthy #weightloss saga continues to unfold #obesity
reuters.com
Eli Lilly has halted a study of an experimental drug, designed to prevent obesity patients from losing too much muscle, due to strategic business reasons, according to a U.S. registry of clinical...
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9/ Shoutout to co-first authors @jhibbert_phd and @kentjorgenson_ and the rest of the team pushing this 8-year-long project to the finish line. The next step is to get it published. Please give it a repost if you think it will be impactful for the field.
biorxiv.org
Mechanical loading drives skeletal muscle growth, yet the mechanisms that regulate this process remain undefined. Here, we show that an increase in mechanical loading induces muscle fiber growth...
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