Andrew Brack
@BrackLab
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Scientist interested in preventing functional decline during aging. Program Manager at ARPA-H. Interests: Crypto, Everton FC and Boxing. Views are my own.
CA
Joined April 2012
What if we had therapies to extend healthspan and prevent the onset of age related diseases? I’m excited to announce my first @ARPA_H program, PROSPR. The goal is to develop validated surrogate biomarkers, new clinical endpoints and therapies to collectively extend healthspan
What if we could predict age-induced health issues before they happen? Our new PROSPR program aims to identify biochemical and physiological markers, paving the way for faster, more targeted aging research. https://t.co/0euJylCcwa
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Kosmos, our newest AI Scientist, is available to use today on our platform. Watch here as three of our scientists describe what Kosmos is, and how it can accelerate scientific research.
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Super excited to play
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Fun day hosting the OpenADMET on-site today including @AndyKilianski and @ARPA_H team, @fraser_lab and team, @wpwalters and team at @OctantBio .
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4 days until we unleash the playbook for fueling your scientific adventure with DeSci! Tell your favorite ambitious researcher
Join us next THURSDAY for a livestream exploring how Bio is helping researchers fund and accelerate their work with @jamessinka & @eperlste. We’ll walk through how launching on Bio works and how decentralized science can offer a faster, easier path to biotech funding and R&D.
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📢 We're hiring someone to help save millions of lives from heart disease. This role is about architecting a new fund, shaping its strategy+ driving interventions that could reshape global cardiovascular health. Apply now or share with your networks:
renaissancephilanthropy.org
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Happy to share this new publication from work done back in the day. Introducing “Hyperoidy”, the increase in muscle fibre volume, membrane surface area, and protein content leading to a larger cross-sectional area and greater force production, without myocyte fusion. Based on
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Is Glp1 a longevity drug? There are two points here 1) the definition of a longevity drug and 2) is fat reduction a bona fida anti-aging mechanism. At the moment there is no formal accepted definition of a longevity drug, but from a personal perspective I would say a longevity
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📢 We're currently hiring for a number of technical and functional roles: - 3 x Technical Specialists - Head of Data + Technology - Content + Brand Manager Check them out (+ get notified of new roles when they open) ↓
aria.pinpointhq.com
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Excited to share some work that came out of my lab when I was at UCSF. Thanks to @UCSFstemcell @UCSFOrtho and @calico, We studied cellular dynamics and trajectories through single cell RNA Seq, heteromotility analysis and Cell Painting, to identify key regulators of stem cell
biorxiv.org
For efficient regeneration, muscle stem cells (MuSCs) transition out of quiescence through a series of progressively more activated states. During MuSC aging, transition through the earliest steps is...
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The commercial and regulatory market have incentiviized companies to go after muscle mass as a consequence of obesity regulated drugs. Sarcopenia is a serious problem in of itself. Go build the drugs that solve it.
Semaglutide Impact On Lean Mass "The proportion of lean mass relative to total body mass increased significantly with Semaglutide, both at 7th and 12th month compared to baseline" @BevTchangMD @MichaelAlbertMD @DrNadolsky @DrKarlNadolsky @NutritionMadeS3 @drmatthewnagra
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A request: Let’s build with data. Please share your health and biomarkers before and after. There is a lot of uncertainty around these compounds. There is an opportunity here to levitate above the n of 1 experiment.
my latest peptide stack: BPC-157 (0.5mg daily) Thymosin alpha 1 (2mg every 3 days) Retatrutide (2mg once per week) SS-31 (10mg 5x per week) Semax (0.5mg as needed)
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It is clear that sleep is important and many technologies advertise to promote deep sleep (which occurs primary in the earlier part of our sleep cycle). I’d like to know who is developing solutions targeting the latter part of sleep cycle REM stage of sleep, because that’s where
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Still got time..phew😂
Silicon Valley is obsessed with 20-year-old founders. But there is no age limit to starting a business. While everyone thinks older people don't play, the data says otherwise:
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Excited to announce MIGHTY: a $28M, 5-year initiative with @crisprcas10 at @UofIllinois, @ginko ! The human microbiome influences everything from immunity to chronic disease, yet current treatments are often blunt and imprecise. MIGHTY’s vision is to harness phages—nature’s own
bioengineer.org
A visionary research initiative is underway at the Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, in partnership with leading industrial and academic institut...
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Another case of compounds impacting male and not females. This issue needs urgent inquiry. It was recently reported that different levels of canagaflozin was found in females and males, suggesting sex differences in drug metabolism. Could drug metabolism explain the majority of
Interventions Testing Program Finds Three New Compounds @DrangowskaWay @LifespanRI
https://t.co/y4eCulAjgi
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Yes
We have published negative results, eg on RNA editing and aging in rats, also screens that came up empty. Science doesn't always work as expected and it’s important to share those so others avoid the same dead ends. Please see: https://t.co/imXDoOLL1S
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I was asked my thoughts on the new approval of Forzinity-the first and only FDA approved treatment for Barth Syndrome. The approval for this rare disease is most importantly a massive win for the patients. Secondly it’s a success for the field of mitochondrial biology as it will
@BrackLab @KarlPfleger Seems really promising. Any thoughts?
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