UCSF Broad Stem Cell
@UCSFstemcell
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Discovering the inner workings of stem cells, engineering treatments using genome editing tools, and healing patients by developing life-saving therapies.
San Francisco, CA
Joined May 2018
Exciting progress! 🧬 Collaborative work with @StanfordPeds, @M_Kyle_Cromer's team used CRISPR tools to create a mouse model of a rare juvenile leukemia. Congrats to Roshani Sinha, Devesh Sharma, & Benjamin Lesch for co-authoring this publication. More:
ashpublications.org
Key Points. CRISPR/Cas9-mediated NF1 loss-of-function in human hematopoietic cells induced juvenile myelomonocytic leukemia (JMML) in vivo.Our model accura
Proud to have played a role in this collaborative work with @StanfordPeds. Used CRISPR tools to create a mouse model of a rare juvenile leukemia. Look forward to building on this to develop treatments for this disorder!
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Scientists have created the most detailed maps yet of how our brains differentiate from stem cells during embryonic development and early life https://t.co/h81hvjdu9h
nature.com
Nature - A collection of studies that chart how mammalian brain cells grow and differentiate is a ‘very valuable’ tool for neuroscientists.
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This week, we published in @ScienceMagazine an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps. Grateful to @HankGreelyLSJU for co-leading
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ISSCR & @StemCellNetwork are seeking nominations to form a working group of early career scientists & senior trainees in stem cell & regenerative medicine research who will provide perspectives on global workforce development. Nominations due 5 December👉 https://t.co/oxuCC5xYZu
isscr.org
The International Society for Stem Cell Research (ISSCR) and the Stem Cell Network (SCN) are pleased to partner to lead a joint initiative and a global conversation on workforce development in...
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More powerful tools for understanding the brain. 🧠🔍 Today, comprehensive, cross-species developing brain cell atlases were released to help advance health and disease research. 🧵 #studyBRAIN #BICAN @USBrainAlliance
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New in @Nature, @LabNowakowski & team use barcoded lineage tracing to reveal how different cell types in the human brain form, identifying a transition during development when some progenitors shift from making excitatory to inhibitory neurons. https://t.co/Mm2WBqx9bV #studyBRAIN
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Expanding cell-type atlases to include developing human, mouse and non-human primate brains using multimodal genomics.
nature.com
Expanding cell-type atlases to include developing human, mouse and non-human primate brains using multimodal genomics.
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Sharing JinYoung's latest work @UCSFAging @UCSFstemcell in collaboration with @Lindsay_LaFave on how senescent fibroblasts program tumor plasticity and metabolism @CellStemCell. JY is starting her own lab @inhauniv to continue this work. https://t.co/yWUfgq4WAB
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Applications are now open for the Stanford course on neural #assembloids! Deadline: December 12
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⏰ Today is the last day to submit a nomination for the ISSCR 2026 Board of Directors election. Nominate your colleague or yourself 👉
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Thrilled to be selected as an #ISSCR2026 Ambassador! The @ISSCR 2026 Annual Meeting will take place in Montréal, Canada on 8-11 July 2026 and features 4 days of cutting-edge stem cell science and global research talks. Learn more here: https://t.co/LBUyuWl5py
#isscr2026
invt.io
Register now
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We’re 5 days away from the #BayAreaScienceFestival! 📅 Oct. 25 🕚 11 am - 4 pm 📍 UCSF Mission Bay Campus Come find the Biohub booth (near the food trucks) to learn about #zebrafish and organelles, and pick up some cool stickers! #ScienceOutreach #BayAreaFamilies #STEMkids
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Excited to share some work that came out of my lab when I was at UCSF. Thanks to @UCSFstemcell @UCSFOrtho and @calico, We studied cellular dynamics and trajectories through single cell RNA Seq, heteromotility analysis and Cell Painting, to identify key regulators of stem cell
biorxiv.org
For efficient regeneration, muscle stem cells (MuSCs) transition out of quiescence through a series of progressively more activated states. During MuSC aging, transition through the earliest steps is...
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Join us today, 10/16, for Getting to Patients! Dr. Claire Clelland will share “Developing CRISPR gene therapy for C9orf72 FTD/ALS: the path ahead to clinic” with Special Guests and perspectives from a family with the C9orf72 gene https://t.co/GldDMEsxec
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Congrats to @M_Kyle_Cromer on receiving a @NIH Director’s New Innovator Award! Cromer’s working to treat sickle cell disease by helping bone marrow produce healthy red blood cells—without the need for harsh chemotherapy. #UCSFProud
https://t.co/wcgHdD8aCC
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Why Does Female Fertility Decline So Fast? The Key Is the Ovary. New in Science: @czbiohub & @UCSF team led by Eliza Gaylord, Mariko Foecke, Ryan Samuel, Bikem Soygur, Tara McIntyre, @FaranakFattahi & @DJ_Laird compared human & mouse ovaries across age.
ucsf.edu
New research shows that the surrounding cells and tissues of the ovary play a crucial role in how eggs mature and how quickly fertility wanes.
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On #StemCellAwarenessDay, we reflect on CIRM’s mission since 2004: advancing stem cell & gene therapy research in California. To date, we've approved $4.6B to support innovation, education, & infrastructure. Take this fun quiz made by a CIRM Scholar: https://t.co/y3bjVuSfKb
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For #StemCellAwarenessDay, a look at a human neuron grown from stem cells, captured by Dr. Yonatan Perez (@Kriegsteinlab). This work could inform therapies for neurological disorders and brain regeneration.
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Congratulations to our Broad Center members (Conklin, MacKenzie, Li, Bruneau, and Willenbring) and colleagues on their newly awarded CIRM Discovery (DISC0) grants! 🔬
“Discovery research is critical for uncovering novel disease targets and biomarkers that we can translate into therapies for clinical use,” said Kelly Shepard, PhD, Director of Discovery & Education programs at CIRM. Read the full announcement: https://t.co/tT8zdFHUsw
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Office view goals? The UCSF Broad Stem Cell Center delivers—morning fog and evening glow included. Thanks, Lael & Cassie, for these snapshots! #UCSF #Dolby #KarlTheFog #OfficeViews #CampusViews #GoldenHour
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