FeigeLab
@FeigeLab
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Translational research on Muscle and Aging biology / NIHS Nestle Institute of Health Sciences / @EPFL Ecole Polytechnique Fédérale de Lausanne
Lausanne, Suisse
Joined June 2019
Exciting translational publication just out @jclinicalinvest on a nutrition screen for #stemcells, #muscle #regeneration and #Aging. Fantastic work from our ex @epflSV student @SaraAncel & great collaborative team from Nestle R&D. 🧫💪🏃♂️.
Excited to share the discovery of nutrients that stimulate MuSCs during #Aging in @jclinicalinvest 🎉 Very grateful to all fantastic teams @RemiRmounier @GondINMG @Isabscionti and stellar colleagues JorisMichaud PascalStuelsatz @FeigeLab 🙏 #myotwitter.
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RT @HornbergerLab: 1/10 Excited to write this thread summarizing our new paper in @NatMetabolism, which identifies a potentially critical p….
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RT @ShukryHabib_Lab: Join us in Lausanne 🇨🇭 for the Lac Léman Regenerative Medicine Symposium, Sept 17–19, 2025! 🔬. Stem cells, aging, bioe….
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RT @NatureAging: Online now!✨RESEARCH: using multi-omics analysis of patient samples, Zuo et al link disrupted BCAA catabolism to sarcopeni….
nature.com
Nature Aging - Using multi-omics analysis, Zuo, Zhao, Wu, Wang, Wang and colleagues report disrupted branched-chain amino acid (BCAA) catabolism in skeletal muscle samples from patients with...
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A new way to think about disrupted amino acid fluxes between #mTOR signaling and #mitochondria oxidation as a new cause of #sarcopenia.
📎And see the associated News and Views by Jerome Feige here:
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A new musculoskeletal tissue is born : lipocartilage !.
science.org
Conventionally, the size, shape, and biomechanics of cartilages are determined by their voluminous extracellular matrix. By contrast, we found that multiple murine cartilages consist of lipid-filled...
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Converging results on impaired mitochondrial calcium as new hallmark of #aging in neurons and skeletal muscle 🧠 💪.
cell.com
Gherardi et al. identify that aging and disability impair mitochondrial calcium uptake in skeletal muscle via MCUR1. Food-derived polyphenols increase the import of calcium in mitochondria by binding...
New findings in mice have uncovered a crucial mechanism linking neuronal activity to mitochondrial function, researchers report in Science, revealing a potential pathway to combat age-related cognitive decline. 📄: #SciencePerspective:
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🙏.
Top altmetrics score 2024: #8🏆✨. @Vinz_Sorrentino, @FeigeLab (@NUSMedicine, @EPFL) and co-authors identify trigonelline as a human metabolite that can be used for NAD+ synthesis and that improves #muscle function in #aging worms and mice 💪🐭.
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A message to relay: Sarcopenia is not just any sort of muscle wasting, its the loss of muscle mass AND strength with old age (different from cachexia secondary to cancer/COPD/CKD/CHF or disuse atrophy during immobilization…).
Sarcopenia ≠ low muscle mass. Main differences between causes, dysfunctions, and outcomes associated with sarcopenia and low muscle mass👇. #muscle #sarcopenia #Health .
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Science based nutrients stimulating muscle stem cells for regeneration and aging 😀.🙏 to all authors, reviewers and editors.
Nutrients that stimulate muscle regeneration during muscle recovery and aging!. @SaraAncel, Joris Michaud, @FeigeLab & team show nicotinamide and pyridoxine enhance muscle regeneration in aged mice: . @GondINMG @GarciaPaulineJ
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New study @Cell_Metabolism on #MitoCa2+ during muscle #aging with a novel #polyphenol for dietary intervention. Great collaboration with UmbertoDeMarchi @dsb_unipd @linusgaia @KeithMGodfrey & great team !. #sarcopenia #nutrition #aging #mitochondria.
cell.com
Gherardi et al. identify that aging and disability impair mitochondrial calcium uptake in skeletal muscle via MCUR1. Food-derived polyphenols increase the import of calcium in mitochondria by binding...
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After seeing new world record by @mondohoss600 at #Paris2024 and reading association of elite sports with #longevity by @marc_dema lab, time to train for pole vaulting !!!!.
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RT @Kei__Sakamoto: A PhD position on metabolic signaling #AMPK is available in our Group @LabSakamoto at @Metabolcenter in Copenhagen. See….
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RT @davidjglassMD: Each year, the journal Skeletal Muscle's Impact Factor keeps going up. Now it's at 5.3 for 2-year impact, 5.0 for 5-yea….
skeletalmusclejournal.biomedcentral.com
The only open access journal in its field, Skeletal Muscle publishes novel, cutting-edge research and technological advancements that investigate the ...
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RT @ISMCopenhagen: @grith_hojfeldt giving a stellar presentation at #ibec2024 @UL on our recent collaboration with @FeigeLab and colleagues….
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RT @AnaisFrancoRom1: Happy and proud to share our new paper about MYTHO in @jclinicalinvest 🎉. “ C16ORF70/Mytho promotes healthy ageing in….
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1/ we generate a new tool that can be shared in the community. 2/ we confirm that Myf5 expression marks the depth of #quiescence and self renewal capacity via asymmetric division. 3/ we demonstrate that #aging specifically affects MuSCs with deep quiescence (Pax7+/Myf5-).
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Our new model to study #muscle #StemCell fate and dynamics in vivo with applications to #regeneration and #Aging. Congrats @SaraAncel JorisMichaud @BentzingerLab PascalStuelsatz & all coauthors. #myotwitter #quiescence #regeneration #aging #Pax7 #Myf5.
cell.com
Ancel et al. introduce StemRep, a tool that enables real-time monitoring of Pax7 and Myf5 proteins in muscle stem cells. The authors describe a deeply quiescent muscle stem cell subset that is...
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RT @RemiRmounier: Two days before the end of the early bird application for our EMBO workshop "Skeletal Muscle Development, Metabolism, and….
meetings.embo.org
Skeletal muscle plays a crucial role in human health at every stage of the life, from embryonic development to postnatal maturation, throughout adult life, and during the aging process. This EMB…
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