Matthew S. Alexander
@Matt_Muscle_Guy
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Geneticist, Skeletal Muscle, Drug development, Gene therapies. Non-coding RNA, and Zebrafish Aficionado. All tweets are my own. Instagram @thealexanderlab
Birmingham, AL
Joined March 2014
New #Oncogene journal paper: The tumor suppressor pRb and its relative p130 are required to maintain murine adult skeletal muscle homeostasis.
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New #MolTherMethClinDev paper: Enhanced therapeutic potential of a microdystrophin with an extended C-terminal domain.
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Interesting new @NatureComms paper: Early-life exercise extends healthspan but not lifespan in mice.
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Congrats to @LorsonLab and colleagues for their new @hmg_journal paper: Novel neurofilament light (Nefl) E397K mouse models of Charcot–Marie-tooth type 2E (CMT2E) present early and chronic axonal neuropathy.
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Congrats to @jyoti_k_jaiswal, James Novak, and colleagues on their new #CellDeathDis paper: Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy.
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New @hmg_journal paper: A discrete region of the D4Z4 is sufficient to initiate epigenetic silencing. #FSHD
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RT @JuleenRZierath: Our latest: HIF1α mediates circadian regulation of skeletal muscle metabolism & substrate preference in response to tim….
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New @JCI_insight paper from Villalta and Spencer labs: Macrophage-derived Spp1 promotes intramuscular fat in dystrophic muscle.
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New #SkeletalMuscle paper: Abnormalities in the genioglossus muscle and its neuromuscular synapse in leptin-deficient male mice.
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New @NatureComms paper: Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia.
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RT @CraigAGoodman1: Evaluating skeletal muscle wasting and weakness in models of critical illness.
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Some good news amidst the chaos, my lab officially received our notice of award for a #DoD CDMRP DMD grant focused on evaluating new therapies that impact DMD neurological symptoms. Excited to work on this project with Karen Gamble’s lab in UAB Psychiatry.
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New @jclinicalinvest paper: Iron supplementation alleviates pathologies in a mouse model of facioscapulohumeral muscular dystrophy. #FSHD
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RT @CraigAGoodman1: Extreme exercise in males is linked to mTOR signalling and onset of amyotrophic lateral sclerosis..
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New @NatureMedicine paper: AAV mini-dystrophin gene therapy for Duchenne muscular dystrophy: a phase 1b trial. #DMD
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RT @GGouspillou: Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy | Nature….
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Interesting new #JACC paper: Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation.
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New @NatureComms paper: In vivo self-renewal and expansion of quiescent stem cells from a non-human primate. #MuSC
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