Amanda Lund Lab
@theLundLab
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the Laboratory of Lymphatic Immunobiology - exploring the contribution of lymphatic transport to dermal and anti-tumor immunity @nyulangone
New York, NY
Joined May 2018
Lymphatic vessels disseminate antigens, leukocytes, lipids, metabolites, and tumor cells between normal and malignant tissues dynamically reprogramming the host over time 👇 - still lots more to learn about their impact on micro and macro tumor progression and immunotx
Tumour-associated lymphatic growth & remodeling were once viewed as passive means for lymphatic spread. In this #Review, @theLundLab provide a working framework for the role of the lymphatic system in tumour progression & response to immunotherapy. https://t.co/ygOh8epgAl
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We had a lot of fun with this one - Lymphatics meet B cells with @CarlaTheNove! @nyulangone 👇 Sometimes less is more
@biorxivpreprint Lymphatic constraint of germinal centers optimizes protective antibody responses https://t.co/Q410ylIqnE
@theLundLab
@nyulangone @CarlaTheNove
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We are super excited about this conference - see below! We have an awesome line up and lots of built in time for discussions and informal interactions.
🚨Grant and Talk Opportunities Available! Click here to register and apply now: https://t.co/aTJcL8YcuR We look forward to welcoming you to #CancerImmuno next year!🇵🇹🌞 #FusionImmunology #FusionCancerResearch
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Excited to share our manuscript defining the role of CXCR6 in CD8 TRM formation in skin - hint, its not migration - led by then graduate student @TaylorAHeim with help in revision by @IbrahimOchapa @J_Immunol
https://t.co/HOHnL5xdOE
academic.oup.com
Abstract. Tissue resident memory T cells (TRM) provide protection against local re-infection, and yet the interstitial signals that govern their formation
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CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @J_Immunol @theLundLab @TaylorAHeim @nyugrossman 🇺🇸 https://t.co/affihMkENl
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Check out this beautiful new study by Miranda Hunter, @whitefishlab & team linking mechanical force to phenotype switching and tx resistance in melanoma. And the brilliant 1st author is on the job market! 🐟✨
nature.com
Nature - Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and...
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Immune Tolerance and Surveillance: Implications for Cancer and Autoimmunity— Amanda Lund, Mark Anderson, and Chen Dong will address this topic in a plenary session at the #AACRimmunity25 Conference (September 24-27; Montreal). Learn more: https://t.co/P0vDzadVgT
@theLundLab
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We are putting together an exciting program with fresh perspectives and new biology!! Come join us next year in Portugal! @DelgoffeLab @Joshilabyale 🪐⏳
🚨NEW CONFERENCE ALERT! SAVE THE DATE! Cancer Immunology: Across Space & Time 📅Date: 10 Jul - 13 Jul 2026 🌏Location: Lisbon, Portugal 📢Early Bird & Talk Submission: 15th January 2026 Don't miss out, Register now ➡️ https://t.co/lb2v5CWufa
#CancerImmuno #FusionImmunology
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Congrats to all on a labor of love. I recall "pd-1 is boring" as a grant review comment. Not so boring in fact... https://t.co/kHAaADhhPY
nature.com
Nature Immunology - Anandasabapathy and colleagues show that the inhibitory receptor PD-1 impacts the specification of tissue-resident memory T cells in the skin.
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📍Join CRI Lloyd J. Old STAR Dr. Amanda Lund @theLundLab @nyulangone at 10:15 AM today for #AACR25's SY20 - Hubs of Anti-Tumor Immunity: Lymph Nodes and Lymphoid Structures! Learn more about this session, and about Dr. Lund's presentation: https://t.co/iQ6TZBhCwL
@AACR
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#AACR25 come check out SY20 Wednesday at 10:15am to discuss Lymph Nodes and Lymphoid Structures in Cancer with me, @BcellBruno and @ZivShulman !!
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Mark Foundation Emerging Leader Award winners are making a splash at #AACR25! 🎉14 are chairing or presenting at plenaries and sessions throughout the weekend. Get the full list of grantee presentations: https://t.co/196EypfBwR
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Cancer research cannot wait! In response to @NIH uncertainty & funding cuts, we’re committing $2.5M to support 10 additional postdoctoral fellowships over the next year at leading universities and research centers worldwide. Details: https://t.co/7p0tHTIaTw
#CancerResearch
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Science is an investment that pays enormous dividends. So if you’re business-minded, it’s an offer you can’t refuse! Here's my full speech from the Stand Up For Science rally in DC today (Link and text below)
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Basic science is inspired by curiosity, accountable to evidence, and subject to peer review. Politics should have no role.
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In an unprecedented move, the US National Institutes of Health has begun mass terminations of research grants that fund active scientific projects because they no longer meet “agency priorities”. https://t.co/ALQlFtfuVd
nature.com
Nature - Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.
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🔬As we close this year’s #BlackHistoryMonth, I honor the legacies of those who persevered, innovated, and expanded human knowledge—despite the obstacles before them. A personal reflection on legacy, science, and the responsibility of diversity, equity, & inclusion (DEI). 🧵👇
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This is a thread on our paper by Eric Fagerberg . KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection https://t.co/wS3WiiJdqJ
science.org
Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress...
An interesting target, but we think it will be insufficient without other factors like Tbet and Zeb2. Experiments are ongoing to test these ideas. Lastly I want to thank a few people who helped in the process. @sarah_h_ross who handled our paper and especially our collaborators
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