#Immunology out now @ScienceMagazine. After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen. By Jobinet al.

#Immunology out now @ScienceMagazine. Regulatory T cells inhibit pain sensing in female, but not male, mice. By @EloraMidavaine, @sakeen_k et al.

ICYMI by first release - now in print @ScienceMagazine:. Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection. By @CicaCanesso, @victora_lab, @danmucida et al

#Immunology by First Release @ScienceMagazine. In mice, during immune responses accompanied by elevated self-antigens, autoreactive CD4 T cells must be restrained by regulatory CD4 T cells with the same antigen specificity to prevent autoimmunity.

#Immunology out now @ScienceMagazine. Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases. By Maxim Zaslavsky @zazius, Erin Craig, @anshulkundaje @ScottBoydLab et al.

#Immunology out now @ScienceMagazine: . In mice, the transcription factor KLF2 keeps activated CD8 T cells on track to differentiate into functional effector T cells. By Eric Fagerberg, Nikhil Joshi @Joshilabyale et al

ICYMI by First Release - now officially in print @ScienceMagazine. Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations. From Shixin Ma, Sue Kaech et al. #immunometabolism

Not long to go now! Don’t miss out on applying for the NOSTER & @ScienceMagazine Microbiome Prize! . Enter: More details: ⤵️.

This Perspective from Aaron Ver Heul (@aaronverheul) puts the work of Andrew Liu, @KaplanLab et al into context. #Immunology @ScienceMagazine

#Immunology out now @ScienceMagazine: . Scratching in mice promotes pain-sensing neurons to release a neuropeptide that stimulated antigen-activated mast cells to degranulate and produce inflammatory mediators. From Andrew Liu, @KaplanLab et al

ICYMI by First Release - now officially in print @ScienceMagazine:. Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation. By Andrew MacLean, Michel Nussenzweig et al. #Immunology

#Immunology out now @ScienceMagazine . ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting.

If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 yrs don’t forget to apply for the NOSTER & @ScienceMagazine Microbiome Prize!. Grand Prize: $25K & your essay published @ScienceMagazine. Deadline: Feb 14th.Enter:

#Immunology by first release now @ScienceMagazine. Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation. By Andrew MacLean, Michel Nussenzweig et al.

This Perspective by Sonja Best and Adam Hage puts tuning the MAVS signalosome by cellular mRNAs into context. #Immunology @ScienceMagazine

#Immunology by First release now @ScienceMagazine. Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection. By @CicaCanesso, @victora_lab, @danmucida and colleagues.

#Immunology out now @ScienceMagazine. An unstructured region within MAVS interacts with cellular, rather than viral, RNA. This alters how MAVS interacts with other proteins and influences antiviral responses. By @nandangokhale, Ram Savan et al.

#Immunology out now @ScienceMagazine . Biased antibody responses to influenza strains in vaccines are strongly linked to genetics. Coupling antigens from different strains together may broaden antibody responses. . By @Vmallajosyula, Mark Davis et al

I am excited to say, we have not one but FOUR #Immunology Research Articles out this week @ScienceMagazine! Individual posts to follow!.

From Feb '24: A treatment combining a soluble IL-15 superagonist with broadly neutralizing antibodies against the HIV-1 envelope protein induced long-term viral control in rhesus macaques infected with SIV-HIV. #Immunology #HIV @ScienceMagazine