Taylor Heim
@TaylorAHeim
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Joined July 2023
When Macrophages Disappear, Skin Blood Vessels Age! Check out our new study @Nature that uncovers how the loss of specific macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology 👇👇 https://t.co/1aYE3OUUVj
nature.com
Nature - Capillary-associated macrophages are selectively lost over time, contributing to impaired vascular repair and reduced tissue perfusion in older mice.
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CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @J_Immunol @theLundLab @TaylorAHeim @nyugrossman 🇺🇸 https://t.co/affihMkENl
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Excited to share the first of many works out of @JJMilnerLab. Be sure to check it out! Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment: Immunity
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#Immunology out now @ScienceMagazine After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen. https://t.co/LOvvkcJXwA By Jobinet al.
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Now out in @ScienceMagazine we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment. https://t.co/dKnuHkQ0W9
science.org
Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii)...
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Cancer immune evasion, immunoediting and intratumour heterogeneity
nature.com
Nature Reviews Immunology - Here the authors describe the different ways that cancer cells evade the immune system and how these mechanisms impact immunoediting and tumour clonality. They suggest...
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Check out our latest paper “Differentiation fate of a stem-like CD4 T cell control immunity to cancer”, led by @Maria_Carden1 now live @Nature
https://t.co/CrbGlEdQja . This work examines how CD4 T cell differentiation dictates the outcome of the cancer response. Thread below
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I'm so excited to be co-running this @KeystoneSymp! We'll be hearing some titans of T cell immunology talking about differentiation in tissues! Abstracts are due November 5th! Put one in and come have a great time with us! #KSTCells25
https://t.co/MdqbC6Hq7M
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Our paper describing in vitro resident memory T cell differentiation in an epithelial organoid model is out at @CellReports
https://t.co/7OtHK1LdWo. If you are excited about T cells and reproductive mucosa, we are looking for postdocs- https://t.co/JfegqlS0V2
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I am pleased to drop our newest story as a pre-print on BioRxiv ( https://t.co/rVQ2TsbtHv). This is a follow up to our paper from a couple weeks back that came out in @J_Immunol ( https://t.co/i9DOwAkgqS). 1/n
academic.oup.com
The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.
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Excited to share our perspective on resident memory T cells in solid tumors!!Huge thanks to @ImmunityCP and @Jodi___G. Amazing figures and artwork from @KatarinaECheng and support from the whole @Masopust_Vezys team. https://t.co/iAsbjUqXdK
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In contrast to exhausted CD39+ T cells in chronic infection, CD39+ TRM cells are fully functional when stimulated ex vivo with cognate Ag @J_Immunol @PCRosato1 @JordIsaacs
https://t.co/4yxnorhmOm
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New in Science #Immunology: CD8+ resident memory #TCells in draining lymph nodes are seeded by T cells traveling from skin infection via the lymphatics in mice. @nyugrossman @theLundLab
https://t.co/8X1hPSdTnf
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Alarm functions of PD-1+ brain resident memory T cells https://t.co/AdXrFNWyUW
#biorxiv_immuno
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Microvascular immunity is organ-specific and concealed in peripheral blood https://t.co/RU5WwPLw2S
#biorxiv_immuno
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