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Leon Smyth Profile
Leon Smyth

@lcdsmyth

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507

Neuroimmunology, meningeal stroma, and barriers 🦠 🧠 | Group Leader @MonashUni | former @kipnislab @wustl postdoc

St Louis
Joined April 2023
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@lcdsmyth
Leon Smyth
2 years
I am excited to share our latest research on the arachnoid barrier, a crucial yet poorly understood structure that partitions the CNS and the dura, out today @Nature. We discovered that gaps in this barrier allow communication between the CNS and the dura.
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nature.com
Nature - Arachnoid cuff exit points create openings in the arachnoid barrier enabling the drainage of cerebrospinal fluid and exchange of molecules and cells between the dura and the subarachnoid...
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@Maca_deAndres
Macarena de Andrés
5 days
As in life, academia is about overlapping stages. Now it's one of those moments: closing (euphemism for paper under consideration) my PhD work at @RuiBenedito_ lab while starting an exciting new chapter as a postdoc with @StefanieDimmel1. Tweetorial ahead👀 https://t.co/X8NCvMOBVK
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biorxiv.org
Hemangioblastomas (HBs) are highly vascularized central nervous system (CNS) tumours that can become life-threatening, especially in the context of Von Hippel-Lindau (VHL) disease, caused by the loss...
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@NatureBiotech
Nature Biotechnology
5 days
Clearance of intracranial debris by ultrasound reduces inflammation and improves outcomes in hemorrhagic stroke models - @StanfordRad https://t.co/BludN4qtBd
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@TrendsImmuno
Trends in Immunology
10 days
Keep your neutrophils close, but your mast cells closer https://t.co/UNOXUykORY
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@nottalexi
Alexi Nott 🏳️‍🌈
16 days
Happy to share our latest work led by two talented PhD students, Kevin Ziegler and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @UKDRI and @alzassociation. https://t.co/IwSMJAY0w5
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@LabWaggoner
Waggoner Lab
24 days
T-ALL exploits a neural proinflammatory pathway to colonize the meninges @jclinicalinvest https://t.co/7XJF3qf51L
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@LabWaggoner
Waggoner Lab
26 days
Tertiary lymphoid structures in a subset of gliomas that show signs of functional adaptive immune activation and are associated with longer overall patient survival and an immune-permissive tumor microenvironment @ImmunityCP @K_Imkeller 🇩🇪 https://t.co/5goCN0454e
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@karchlab
Celeste Karch
27 days
Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 ⁦@WashUMedADRC⁩ ⁦@alzassociation
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alz-journals.onlinelibrary.wiley.com
INTRODUCTION Genome-wide association studies have identified MS4A4A, a microglia-enriched gene, as a modulator of Alzheimer's disease (AD) risk. Common variants in MS4A4A affect AD susceptibility,...
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@jonykipnis
Jonathan Kipnis
27 days
Congratulations, @tmamuladze for this very well deserved recognition by @WashUdbbs 👏👏👏
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@jonykipnis
Jonathan Kipnis
1 month
Celebrating the finale of an amazing #RTN2025 and also acceptance of ⁦@lcdsmyth⁩’s paper 🤩
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@jonykipnis
Jonathan Kipnis
1 month
Next #ReThinkNeuroimmunology (#RTN2026) will be at the @WeizmannScience 🤩 We are so excited to come back to peaceful Israel 🇮🇱
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@jonykipnis
Jonathan Kipnis
1 month
Serious science with serious fun at #RTN2025
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@LabWaggoner
Waggoner Lab
1 month
Spotlight in @ImmunityCP Fibroblasts are not so scar-y in brain injury https://t.co/KxYRrfP8uz on https://t.co/Wz7YyD2yDK @Nature
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@LHohsfield
Lindsay Hohsfield
3 months
Thank you for the wonderful @NeuroCellPress Preview write-up about our recent publication on the velum interpositum (the VI-P of the leptomeninges) @SiegenthalerLab. I'm just disappointed that I missed out on such a good play on words.
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cell.com
The velum interpositum (VI) is a membranous extension of the leptomeninges under the hippocampus. In this issue of Neuron, Hohsfield et al. characterizes cellular properties of the VI in mice and its...
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@LHohsfield
Lindsay Hohsfield
6 months
Excited to share our new paper out in @NeuroCellPress today! Ever wondered how peripheral #myeloid cells get into the #brain? We discovered it's a leptomeningeal structure called the velum interpositum. Check it out here: https://t.co/s5n0hVzQ2U
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@maabellanas
Miguel Ángel Abellanas
1 month
I’m very happy to share the preprint of one of the projects I’ve been working on during my postdoc in Michal Schwartz’s lab at the @WeizmannScience 🧠 Alzheimer’s disease disrupts bone marrow myelopoiesis, leading to systemic immune dysfunction. https://t.co/jVj4k8rxPf
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biorxiv.org
Accumulating evidence suggests that both innate and adaptive immunity play crucial roles in combating Alzheimer’s disease (AD). Specifically, enhancing the homing of monocyte-derived macrophages to...
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@AndyShih_Lab
Andy Shih
3 months
It is debated whether poor #blood flow underlies white matter loss in #aging. Our recent study in aged mice supports this idea: Impaired drainage through rare, deep-reaching #venules causes mild #hypoperfusion that triggers inflammation and demyelination. https://t.co/nDVjgZjnWa
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@AusNeuroSoc
Australasian Neuroscience Society (ANS)
1 month
Find out more about #ANS2025 symposia for the Hobart 2025 ANS meeting including "New insights into the roles of cerebrovasculature in nutrient supply, waste removal, neurodegenerative diseases and beyond" here: https://t.co/9ztAE2SgYi
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@science_sophie
Science Sophie
1 month
@science_sophie
Science Sophie
1 month
Dear Everyone, I've read the #NHMRC draft strategy and I have notes ... So I'm going to...🧵🤔🧵😱🧵😵‍💫🧵🙏🧵🧵🧵 #NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
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