Alexi Nott ๐ณ๏ธโ๐
@nottalexi
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Group Leader at UK Dementia Research Institute at Imperial @ukdri | Lecturer @imperialbrains | Epigenetics in brain disorders | LGBTQ+ champion | He/him
Toronto, Ontario
Joined February 2018
Nice to see this review out with.@IRHoltman! | Genetic insights into immune mechanisms of Alzheimerโs and Parkinsonโs disease |
frontiersin.org
Microglia, the macrophages of the brain, are vital for brain homeostasis and have been implicated in a broad range of brain disorders. Neuroinflammation has ...
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RT @LukensJohnR: Astrocyte priming enhances microglial Aฮฒ clearance and is compromised by APOE4 @NatureComms .
nature.com
Nature Communications - How brain glial cells form an immune memory can impact disease pathology. Here, the authors show astrocyte priming boosts Aฮฒ clearance by microglia, a protective...
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RT @Fusion_Conf: ๐จ Donโt forget to register for #Neuroepi25!.โณ The deadline is fast approaching - Thursday 7th August 2025. This is your laโฆ.
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RT @Fusion_Conf: ๐ข Big news! #Neuroepi25 has just released the final programme!.๐ Check it out now on the conference website.โ
And don't foโฆ.
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RT @UKDRI: It's a pleasure to welcome a new Group Leader to the UK DRI! ๐ ๐ ๐ฅณ . Prof @PareshMalhotra joins our Care Research & Tech Centreโฆ.
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RT @MootazSalman: Thrilled to join the @UKDRI & @TheBHF as a Group Leader in the Vascular Dementia Centre, and proud to bring the UKDRI toโฆ.
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RT @sj_marzi: How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cellsโฆ.
nature.com
Nature Communications - APOE is the strongest risk gene for late onset Alzheimerโs disease and its expression is upregulated in microglia in response to amyloid beta. Here, the authors show...
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RT @soyonhonglab: Dear immune/glia lovers of brain, gut and beyondโฆ Weโre looking for a lab tech/manager to join our team! Pls see detailsโฆ.
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RT @sj_marzi: Trying to get cell type specific insights from bulk brain epigenetic studies? Check out our new method CHAS for cell type decโฆ.
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RT @sj_marzi: Really nice work from the @nottalexi lab using functional genomics to show that genetic risk for multiple neurodegenerative dโฆ.
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A first first-author paper by Aydan Askarova with Reuben Yaa & @sj_marzi showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways ๐๐ท More to come from Aydan later (hopefully) this year.
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RT @sj_marzi: We are so happy to share our latest paper "CHAS infers cell type-specific signatures in bulk brain acetylation studies of neuโฆ.
cell.com
Murphy et al. develop CHAS, a computational tool that uncovers cell type-specific patterns in bulk tissue histone acetylation data. Applying CHAS to brain disorders reveals distinct cell type targets...
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RT @Fusion_Conf: @nottalexi we are looking forward to your presentation at #Neuroepi25 in Malta.๐.Please share with your followers to letโฆ.
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RT @sj_marzi: We're so thrilled to finally share with you the published version of our CUT&Tag optimization and benchmarking paper "CUT&Tagโฆ.
nature.com
Nature Communications - Cleavage Under Targets & Tagmentation is a rapidly expanding technique, but thorough evaluation and benchmarking against established ChIP-seq datasets are required....
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RT @n_skene: The Dept. of Brain Sciences at Imperial (@ImperialBrains) is recruiting a new Head of Department (link below). Keen to haveโฆ.
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RT @OxfordPDCentre: Thank you to @UKDRI Group Leader @nottalexi for joining us today & for his great talk on โThe Epigenome of brain cellโฆ.
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RT @alessia_neuro: Last day @UKDRI @ImperialBrains before starting my maternity leave ๐ผ I will only briefly come back before heading to Turโฆ.
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RT @ImperialBrains: Are you looking for a fully funded #PhD studentship? . Join our Dr Nurun Fancy for a studentship for 3.5 year project iโฆ.
imperial.ac.uk
Funding is often secured through Wellcome Trust or MRC DTP Fellowships. Further information about this and specific projects studying under the supervision of Departmental supervisors who have...
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