Jonathan Kipnis 💔
@jonykipnis
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Obsessed with brain/immune system communication. Opinions are my own. This is a personal account. RT isn’t endorsement #Neuroimmunology #TcellsMakeYouSmart
Joined July 2009
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A senior prof visited us ~ 1 year ago. My student showed him a cool observation for which we are working on a mechanism. We now found out that a few months later this jerk published a small descriptive paper scooping my student’s initial observation. What should I do?
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PhD students: It’s healthy sometimes to time to ask yourself “why am I doing this experiment?” Often you may genuinely not have a good answer. “Working” during your PhD is not only “pipetting” - it’s also reading, thinking, planning. Don’t let anyone make you forget it.
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Change will come not when PIs stop submitting to Cell/Nature/Science but when exceptional post-docs who happen not to have Cell/Nature/Science publications will be treated fairly by search committees and be getting faculty job interviews and offers from top research institutions.
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Advice for postdoc candidates: If there is a lab you really want to join, don’t wait for an advertised position. Reach out to PI, explain what excites you about the lab/research, explain briefly what you want to do and attach your CV. This applies to my lab too 😉
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Scientific community needs a plan on how a potentially devastating COVID-19 impact on junior faculty, post-docs and grad students could be mitigated. We now focus on preventing the spread for the sake of our most vulnerable and then we should focus on most vulnerable in science.
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What people without little kids don’t understand, is that for those who do have little kids, it’s easier to schedule calls for 8:45pm than 5:30pm. Yes, having kids was our choice. But pandemic wasn’t. Maybe you can compromise so this pandemic does not crush ‘parents in science’?
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I’m thinking to start a thread of shaming of scientists who won’t share their reagents/mice. And I hope others will join. This assholesness of some PIs must stop.
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If PhD was easy it would not have been fun and if all experiments worked as planned it would take ~6 months to graduate. Most of the time we are all dealing with failures - it’s not easy but builds resilience! If you love science - no failure should stop you!
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Very excited to share our new story on the "missing link" for brain's immunity || Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma
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I think there is a confusion between impact factor and prestige/respect of the journal within/by scientific community. A society journal may be half of IF of some other journals, but is more respected and has a more rigorous review process.
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Dear post doc candidates - if you think you are not good enough for the lab of your dreams - you are most probbaly wrong! If your dream lab’s PI thinks you are not good enough for them - you don’t want to be there and this PI will most probably regret one day!
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For postdoctoral candidates who cannot secure their desired labs this year, the situation is devastating. What are their options? Join any lab that offers them a position? Sit out without salary until labs recover? We need a plan to help the most vulnerable.
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Most graduate students reach the point where they realize they are smarter than their PIs. That’s great! This point is the beginning of the end of your PhD. Nobody (not even yoyr PI) should know the literature, methodology and details of your project better than you!
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My grandma 96 years young… asked me what’s new with my science…
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If you’re an advanced grad student, don’t wait for your paper acceptance to look for post doc opportunities. Reach out and engage with potential PIs at least 6-8 months before you’re ready to start. The best timing is when you have just submitted your first-authored paper.
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Advice to postdoc candidates: after you visit a lab for interviews, make sure to follow up within 24h thanking the PI and key lab members. Write individual emails, even if it’s a copy/paste. Even if your experience wasn’t great, make sure to express appreciation for their time.
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Why should virtual meeting cost hundreds of dollars for postdoc to register? What is the expense that conferences are experiencing that justify the cost?
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I’m humbled and honored beyond words! Thank you
@theNAMedicine
and everyone who supported me!
Congratulations and welcome to the 100 new members elected today to the National Academy of Medicine!
#NAMmtg
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Best chalk talks I’ve heard had 3 parts. The main (~65% of the allotted time) focused on the immediate R01 plan (years 1-3), second (~25%) on ‘the next step’ question (years 2-5) and the last (~10%) on a ‘big question/dream’ (years 5-10). Good luck to all those interviewing!
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Everyone makes mistakes. What’s important is that you have the courage to tell your PI about the mistake the moment you learn about it, no matter how ‘late’ this is in the process. If you don’t feel comfortable being honest with your PI - you are working with the wrong person.
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Many complain about editors not dealing well with nasty reviewers. You can also help! If you are a reviewer and see a co-reviewers making unrealistic requests, email the editor and express your opinion about the unfair review. It will be more powerful than if the authors do so.
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Very excited to share a new story from
@kipnislab
led by
@Drieu_Antoine
in collaboration with many others from within&outside our lab on parenchymal border macrophages (PBMs) in regulation of CSF flow with implications to aging and Alzheimer's disease ||
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If your mentor is not answering your emails, you’re NOT to be blamed. And your PI must know about your project, at least enough to answer an email. That’s in a job description. If you need to think how to construct an email to get your mentor’s response – better find another lab.
As a PhD student, my supervisor never answered my emails.
Then I became a PhD supervisor and realised why
A thread🧵 of my mistakes and how to avoid them
#phdchat
#AcademicTwitter
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Recently I was introduced by a colleague (neuroscientist), who said that the only thing he knows about immunologists is that they must love music because they have so many CDs... Unfortunately, the neuro-heavy audience did not get the joke 😂
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Immigrant scientists in the US are often going through much tougher times than their American mates. No family/parents to fall back on, to celebrate holidays with, or to escape to when you must take a few days of break. We don’t need a pity, just an understanding...
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I’m thinking to introduce mandatory vacations
@kipnislab
for students and postdocs (staff does not miss vacations anyway 😂). Whether you want it or not, you have to be outside the lab for X number of days per year… better traveling somewhere to clean your head. Thoughts?
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I might have come up with a definition of success in science. You are truly successful when you can genuinely be happy for achievements (grants, publications, awards) of a colleague ‘next door’.
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In our department we invite postdocs to chalk talks by faculty candidates. I know this is not a usual practice. Why not to let postdocs sit through chalk talks and see what works and what does not? Any reason that most departments exclude postdocs from attending chalk talks?
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I hope
@JoeBiden
assembles a strong task-force of scientists to help him deal with the pandemic. He needs a consortium of experts!
@EricTopol
@florian_krammer
@VirusesImmunity
@vsv512
just to name a few!
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What if labs publish each of their unique methods/protocols in
@biorxivpreprint
and in future papers, instead of rewriting the protocols, we just cite them? We waste so much time on methods by saying the same thing differently just so it’s not a “plagiarism”…
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After almost 13 amazing years at
@uva
our lab
@kipnislab
will be moving to
@WUSTLmed
! We are sad to leave and also excited with the opportunities and new collaborations ahead!
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When I was grad student, a senior/arrogant professor told me after my talk that results could be right, wrong or irrelevant and that mine are irrelevant. This week I’m sharing stage with him at WellcomeTrust Neuroimmunology meeting. Neuroimmunology is no longer irrelevant!
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In the elevator at
#SfN22
:
- what are you doing here?
Me: what do you mean?
- I thought you only interested in other cells of the brain, not neurons.
Me: if it’s a brain, it’s neuroscience, no?
- No
Me: I won’t argue (to myself: is this 2022 or am I back to my 1st SfN in 1998?)
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Colleagues, if you cannot be fair reviewers (for grants and papers) then Fuck You! And Fuck You again!
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Talked with
@drGregBowman
to understand what triggered his tweet and I'm sorry for my stupid subtweet. Too bad he is leaving because we could have formed strong partnership in making
@WUSTLmed
a better place. I pledge to do all possible to make
@WUSTLmed
safer workplace for all!
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Our story on meningeal gdT cells and their derived IL-17a in regulation of anxiety behavior through neuronal signaling is now online
@NatImmunol
! A beautiful work by a fantastic (but twitterless) post-doctoral fellow in the lab, Kalil Alves de Lima ||
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We are here
@WUSTLmed
(or on our way and arriving soon) and we are about to start the next chapter of
@kipnislab
in less than a week.
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My almost 19 and 16 year old daughters went to protest today in Charlottesville. I felt it was the right call to let them do it and express their frustration. We then had a long discussion over dinner about the situation . My wife and I did something right. Proud of my kids.
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Excited to share our new paper demonstrating how CNS immune surveillance takes place.
@JSRustenhoven
is working on a thread to explain the findings step by step. || Functional characterization of the dural sinuses as a neuroimmune interface
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We need to agree on and publish a perspective on equally contributing authorship order. Is it ok to switch an order of equally contributing authors (so that each co-first author puts themselves first on CV). Please comment and indicate if you’re PI/student/postdoc/fellow/editor.
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Social distancing is crucial. But do we really need to shut down research labs? For some postdocs/young PIs this could be catastrophic. Biomedical research isn’t ‘dispensable’ and there are alternative measures. Wearing protective gear? Dividing lab into non-overlapping ‘shifts’?
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People change labs, projects, careers... it’s all normal. It’s all about the match and personal preferences and happiness. No matter what - try to never burn bridges!
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For those perspective PhD students, interviewing these days - you are not expected to read and know every (or any) paper of every faculty member you meet with. I am happy to tell you what we do and am eager to hear what you did and what you would like to do. Interviews are fun!
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@NalediSaul
I know exactly what I want - I want to eliminate such jerks so science world becomes a bit better for all. How to do this - big question...
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I’ve now lived in the USA more than in any other country (3 total) but I still feel like that monocyte that engrafts in the brain and no matter how close to (or even better than 😉) microglia it gets, it will never become a “real”microglia…
#ForeverImmigrant
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It is not about being nice. It is about not being an asshole.
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In today’s
@ScienceMagazine
3 out of 8 articles are from one division (Immunobiology)
@wusm_pathology
! So
@LabRandolph
@TheColonnaLab
and
@kipnislab
came together to celebrate!
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Early in my career I was given an advice, which I’m now sharing - when giving a talk, you don’t impress the audience by presenting extra data over an extra time. Being respectful to allocated time is the key - it shows respect to other speakers, the audience and the organizers.
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Here is the official announcement about
@BIG_CenterWashU
. I am hoping to post about job opening tomorrow ||
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When we stated working on meninges ~15 years ago, nobody cared about "the borders"... over the years "the borders" of the brain have taken the central stage of neuroimmunology! "From esoteric mainstream" could have been an alternative title of this feature
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Rejections and defeats are part of our science lives. They are never easy, no matter how many acceptances and victories preceded… but learning to accept them (and maybe even gain some strength from them) and move forward is critical for survival in academia!
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A beautiful new review from the Nedergaard lab in
@NatRevDrugDisc
on how the glymphatic system could be used for drug delivery! This review contains an important information for designing future clinical studies 👏👍🤩||
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Inspired by discussion with my postdoc: Many of us don't know science history enough. Let's change this. I propose we each include in our lectures brief intro (1-2 slides) on science luminaries that inspire us. We will spread their legacy and educate each other. Agree? Then RT!
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Sometimes in 2021 we will have another lab shut down... after the vaccine, all of us will finally be able to travel and see our families. I expect at least a month if no activity... and, honestly, I can’t wait for it!
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A new mug to sip a coffee from at truly important meetings 🤣
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Why isn’t there a rule that all published mice have to be deposited to become publicly available? Spent now months on (begging for!) MTA for a published cre line to find out they restrict us crossing it with other strains! Why else would I want a cre line if not to cross??? 🤯
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If you have recently started a PI job without having CNS pubs from your training, please respond to let us know your highest IF pub (journal) and your institution. Many talented candidates who don’t have CNS pubs and are anxious about job prospects will be inspired by you! Thanks
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One of the happiest moments - My younger daughter got accepted to her dream school - our beloved
@WUSTL
We are all beyond thrilled!
#WashU2026
that is!
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My daughter said she was jealous of Katie Bauman and that she wished to be the one decoding the image of a black hole! She has the right aspirations! We need to hear more about hero female scientists so that our daughters know that even sky isn’t a limit to what they can achieve!
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A note to self: When you grow old, do not become that grumpy nasty old fart of a scientist who still wants all the attention and by means of achieving it spits poison right and left. Instead, write a textbook and embrace the young!
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Dear PIs (no matter how busy you are), please make an effort to send recommendation letters on your students (applying for post doc) and post docs (applying for jobs) ASAP. It’s pretty embarrassing for a candidate to find out that a letter from the primary mentor is delayed.
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Extension of a tenure clock by one year is obvious and insufficient. Universities should come up with the plan (or plans) how to support junior faculty in a post-COVID19 era! We also need plan for all post doc candidates who will have difficulties finding labs this summer/fall.
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Today is a sad day for me as Israeli. It happened that today I’m also inducted into
@theNAMedicine
. Here is the bright second of the day with the most inspiring
@kkariko
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Colleagues, I see a complete lack of excitement from my lab members to participate in virtual meetings. Do you have similar or different experience? Am I doing something wrong?
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Now officially out… a great effort of
@JasminHerz1
and co-authors on how IL4 regulates memory || GABAergic neuronal IL-4R mediates T cell effect on memory - ScienceDirect
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I feel bad for all those grad students who are defending their dissertations now and cannot have public defenses. This does not make your PhD any less important! Be strong and you will have cool stories to tell your kids and grandchildren!
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The happiest immunology program in the world! Join us! Cheers!
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We are looking for professional biomedical illustrators to help us create striking images for our review. please respond here or DM with info. Thank you!
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DIM DAM DUM (well, no DUM but DIM and DAM 😉)... Excited about this collaboration with the great
@FGinhoux
and
@IdoAmitLab
... ||
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Foundations should provide feedback on postdoctoral fellowships. How can postdocs improve their applications if they don’t know what went wrong? Applicants put so much time and effort - please consider requesting comments from your reviewers and share them with the applicants.
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My unsolicited advice for PhD in biomedicine and MSTP applicants:
During 1:1 with faculty do not ask “What is the most important discovery you made?”. Read about the work and come up with a specific question or ask “what exciting questions your lab is currently working on?”
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I hope that major journals will consider changing their EndNote styles to highlight all co-first authors. What should the next steps be to make a real change? || First authors: is co-equal genuinely equal?
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People who are COVID positive should not be apologizing. It’s a pandemic and if you get it does not mean you are reckless in your behavior. It’s everywhere and not everyone has the luxury of isolating themselves from the world in the comfort of their homes. So let’s calm down 🤦🏻♂️
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It’s fun to receive galley proofs on Friday night with a notice that they need to be returned within 24 hrs. Years of experiments, months of revisions, but the galley proof - 24 hrs! Why is it suddenly so urgent?
🤨🧐🤪
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After your rotations, before considering committing to the lab, ask yourself these three questions: Can I grow to be my very best self in this environment? Can I work with this PI? Will I have the freedom to explore? When answering, consider labmates, PI’s character and finances.
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When I visit for seminars, postdocs often express frustration with
@NIH
4year limit on K99 eligibility. Why not extend eligibility to 5-6 years or come with alternative funding mechanism? Complex projects may take long time but these efforts should be encouraged not punished.
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New NIH funding opportunity for new PI without preliminary data: Early Stage Grant for innovative project that represents a change in research direction and for which no preliminary data exist. Applications must not include preliminary data!!!
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I am truly honored to be joining an exceptional group of academic editors
@JExpMed
. Stepping into huge shoes of
@holtzman4
, who served in this role of many years, and I am happy to keep
@WUSTLmed
presence on the board 😉
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Our paper is out now and if you don’t want to read it, you can read this thread instead 😉 Bravo to co-authors for a fantastic teamwork! 👏
@smyth_leon
and I are excited to share our latest work
@NatureNeuro
! We describe an unexpected form of neuroimmune communication whereby CSF gains direct access to skull bone marrow niches and regulates immune supply to CNS borders.
A thread. 👇
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This is the first slide on my presentations from now until this war is over. If you have a problem with this arguably political statement, please let me know. I completely understand and will happily cancel my talk at your institution/conference. Peace 🕊️
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I have zero patience for those jerks who make any effort NOT to share their mice (or other reagents). You make science space very unpleasant!
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A new work from our lab (in collaboration with many exceptional labs at
@WUSTLmed
) by
@Da_Mesquita_S
(now PI
@MayoClinic
), attempting to link
#MeningealLymphatics
to human Alzheimer's (please read the supplemental figures - a lot of cool data there!) ||
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What do universities do to help post docs? I think all schools should offer subsidized childcare and subsidized (or better free) dinners for post docs (or better all trainees) and their family members. Yes, it will cost a lot but think how much would be gained!
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Those who are most illiterate in science, are the loudest ones in spreading nonsense theories about vaccines. The blame is partly on us, the scientists, for our inability to deliver science to non-scientists. Should we include media classes to our graduate school curriculum?
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Beautiful paper today in
@NatureNeuro
on meningeal lymphatics' role in viral infections (three papers in May issue are dealing with borders of the brain!) "Brain borders at the central stage of neuroimmunology" ||
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Who knew that PhD in epidemiology takes a few weeks?
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Excited to share our new work identifying new routes through which the brain waste is being removed and immune cells may come inside the brain. Congrats to Leon and all coauthors. Thread below! 👇
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I am excited to share a preliminary program of
@BIG_CenterWashU
Symposium for next year. Please scan QR code and apply. Registration is FREE for all but number of attendees is limited. The final program will include short talks selected from the abstracts and a poster session.
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We should appreciate our postdocs every day and every hour. You are the pillars of the scientific progress and I, personally, owe my post docs everything I have. Thank you 🙏
#PostdocAppreciationWeek
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How can you not love this work? The mother of all microglia RNAseq papers! Wow!!! 🤩
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Today at the gym, guy training next to me (and seeing me not being able to move my neck) tells me that he had an infrared treatment and it helped.
Me: what’s infrared treatment?
Him: It’s a non ultraviolet infrared light that rebuilds molecular cells
Me: 😳
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Thank you for all the suggestions. I have just emailed him saying that I don’t believe he stole the idea from my student and asking him to explain why he has not mentioned that his lab had similar results when we shared ours. Let’s see what he says.
A senior prof visited us ~ 1 year ago. My student showed him a cool observation for which we are working on a mechanism. We now found out that a few months later this jerk published a small descriptive paper scooping my student’s initial observation. What should I do?
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Schools are virtual through at least the end of year. I don’t know how parents in science who are on tenure track (or postdocs) will deal with it. Year off tenure clock is insufficient. We need creative solutions, likely not without
@NIH
involvement. And we need them soon.
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Our new
@nature
article on the role of meningeal lymphatics in aging and Alzheimer's disease is now online:
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