Josh Koenig PhD
@jfekoenig
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Following
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B cells and T cells. IgE and Allergy. B cell Tetramers. Multiplexed Imaging. Assistant Professor @McMasterU .
Hamilton, Ontario
Joined February 2013
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Last Seen Profiles
Pinned Tweet
We found type 2 polarized memory B cells! (Maybe the equivalent of Th2 cells?)
I am so excited to see this paper published
@ScienceTM
!
This was a team effort pushed by myself,
@allyssaphelps
,
@KellyBruton_
and our colleagues
@ALK_net
.
🧵1/18
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First day as an Assistant Professor doing... the exact same stuff I did before? 🤔 So excited to use systems and mechanistic immunology tools to answer B cell memory and allergy questions! I'll be recruiting grad students and postdocs soon! DM me to chat all things science ☺️
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This crazy cover was the brainchild of myself and my partner Claud Spadafora. There's a story! A short 🧵1/9
This week's new issue of
#ScienceTranslationalMedicine
has arrived! Researchers uncover stealthy immune saboteurs that drive allergic memory in humans, a new analysis in mice reveals how the brain recovers after stroke, and more.
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Super cool preprint from
@florsheim_eb
+
@RMedzhitov
! Mice are averse to eating allergens they are sensitized to, and there’s a neuro-immune explanation! Clinicians tell me all the time that kids significantly dislike the taste of their food allergen. (1/6)
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Some days are so awesome. I teared up getting this email. (p.s. my students call me budget Hank Green.)
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Not either of our idea. The lab is to thank for making the pipettes walk out of the lab.
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McMaster researchers create instruction manual to detect rare cells that could unlock secrets to allergies
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Very excited that this paper is out. It's a protocol, but it's also a lot more. There's a ton of validation data and recommendations. Great work by
@allyssaphelps
and Diego and a great collab with
@JustinTaylorLab
. A behind-the-paper and thread to follow soon!
@NatureProtocols
#NewNProt
: Tetramers to the rescue: enrichment of extremely rare antigen-specific B cells with tetramer probes
#flowcytometry
#immunology
@allyssaphelps
@jfekoenig
@JustinTaylorLab
@MacImmunology
@UVAImmunology
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I got really excited by the concept of sharing the stories that go untold that exist behind every paper.
Like
@JustinTaylorLab
, I wrote up some of the learnings that came along the way from our recent Nature Protocols paper!
(1/2)
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Thanks for the feature on our paper
@CTVNews
! Hopefully we can turn this finding into better therapies for food allergy! A lot more work to do, and we're ready to do it. 💪 Shout out
@allyssaphelps
@KellyBruton_
@Jordana_Lab
Researchers say they have found the 'smoking gun' for tackling life-long allergies
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Super excited to kick off the New Investigator Forum! Thanks
@CIHR_III
for having me. Excited to meet others starting out as an investigator in Canada!
#OurFutureOurIIINIF
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Wow! Incredible highlight of ours and
@MLafailleLab
's preprints at
@NatRevImmunol
! Thanks so much
@michelle_a_tran
and
@BerinLab
!
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The Koenig Lab is at
#IES2023
. Come on over to the Ask an Expert session to talk about multiplexed imaging using IBEX!
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Had a blast at
#CanNKC2023
! Such a good group of people. Fast friends with
@JeanetteEB
, whose team is doing awesome stuff.
@LabWaggoner
@SunLab_Official
Great chats! Thanks
@NersesianSarah
@Ana_LPortillo
for inviting me to talk at the workshop.
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This is the part of science twitter that speaks to my soul.
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Folks in British Columbia for the
@KeystoneSymp
B/T cell meeting, if you have a chance, visit Lynn Canyon in Vancouver! So awesome! Also come say hi at the meeting! ☺️
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To pay homage to all of these things, and to the fundamental allergy observations we made, Claud and I came up with this crazy idea. What if we took La Grande Jatte and made it a little more... allergic? Claud created this amazing art work... yes- the shrip has a hat. 8/9
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Super proud of the team's accomplishments at
@MacImmunology
Perey Symposium. Special thanks to
@JustinTaylorLab
for the great science, a fun visit, and fantastic advice!
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Great 🧵 from Dr. Maria Curotto de Lafaille about their paper back-to-back in the same issue as ours in
@ScienceTM
. Very insightful. Congratulations Maria and team!
Check out our paper in
@ScienceTM
with insight into how B cell memory for allergen-specific IgE antibodies is stored in CD23+IgG1+ memory B cells in kids with peanut allergies. Similar findings in pollen allergy reported in the same issue by
@jfekoenig
1/n
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We pitched the concept to
@courtney_malo
and
@ScienceTM
and they were just as excited about it as we were. Such an open and accommodating team, and a very, very positive editing experience. Send your allergy work to them! 9/9
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The deep concern around ChatGPT in higher education reveals how unwilling academia is to change. Most classes are using archaic educational practices that predate computers. The world is not the same anymore. Teaching the old way won't prepare our students for the future.
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Check out the first commentary from my lab published today in
@AllergyEaaci
. We discuss the implications of Aung et al.'s work on antigen stability in the B cell follicle, published in Science earlier this year, for allergy and immunotherapy. 1/3
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I have so many but here are the ones with twitter/x.
@allyssaphelps
@VOlyntho
@KellyBruton_
@CKaushic
@chaudr8
@AmyEGillgrass
@StephanieEisen
@JenGommerman
@CarlaTheNove
@drdeannasanter
@GuzzoLabUTSC
@sheilasinghlab
@DavidsonBela
@JeanetteEB
@JanaBilanovic
, I've missed many
10 amazing women in STEM- pick it up and keep it moving!
@ScientistStephG
@sophiahlge
@RebeccaLynchLab
@SwisherLiz
@lawrensonlab
@immunegirl
@airdlab
@RachGolden
@FondufeYvonne
@MaiselLab
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Our most recent review is out now in JACI. I might put together a thread about it later!
Allergic diseases result from aberrant production of IgE antibodies against otherwise innocuous environmental antigens. Read a Rostrum on CD4+ T cells and T follicular helper cells. Could Tfh plasticity be harnessed for therapeutic benefit?
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To borrow from another piece from
@RMedzhitov
et al, this observation speaks to food allergy evolving as a hard-wired quality control system. Bad food? Reject it. Why, then, has this mechanism evolved against foods that are fine for most people? (4/6)
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Some goodbyes are just too hard... Like when they take the fancy demo microscope back to its home 😭
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I'm looking for a post-doc! Not for any particular purpose, just not sure if they exist anymore.🧐
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Thanks to all of my incredible mentors and friends who supported me along the way. I've been so fortunate to receive amazing advice from so many folks. I've been especially inspired by those who have been so kind and helpful the very first time we've met. Great role models.
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Some days, things just make sense. For example, when one of the kindest and most intelligent folks out there win a top award.
@KMcNagnylab
is a lucky group. Congrats
@MaggieChopra1
!
I feel so privileged to be recognized as a 2023
#VanierScholar
. Special thanks to my supervisor, Dr. Kelly McNagny, and the exceptional
@KMcNagnylab
team. So grateful for the support of my friends/family, mentors (
@dufourlab
,
@jfekoenig
,
@Jordana_Lab
) and the
@UBCMDPhD
community!
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It's amazing to see persistence and effort pay off.
@VOlyntho
captured our first microscopy images on human tissues today! So much more work lies ahead but we need to celebrate the little things.
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Awesome to see this community resource finally online! The IBEX Imaging Community is a collaborative, open science resource for multiplexed imaging. It is home to a massive list of community validated reagents that is relevant to anyone doing imaging!
1/5
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Amazing step for Canadian immunology and
@uoftmedicine
. Jen is a forward thinking innovator who champions equity and who engages in science in a kind and compassionate way. Thank you
@UofT
for giving me and other ECRs someone to look up to!
A big moment for me: I started as an u/g then grad student in Immunology
@UofT
. After 20 years of running my lab
@uoftmedicine
, alongside my friends and colleagues I am now excited to lead the Dept as Chair. Thank you all my mentors, family and friends for support along the way.
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Did this quality control system evolve purposefully for foods, or was its use primarily for other noxious substances? Are foods still an error? So many awesome questions arise from such elegant work. Bravo to all the authors, I can't wait to see the final version! (6/6)
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I've taken a ton of great advice from
@LabListon
's twitter over the past year. Here's another paper that was written with
@LesageS_CRHMR
who just volunteered a bunch of her time at the
@CIHR_III
New Investigator Forum, and who I learned a ton from in the past week!
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This is the right move. Other grad studies programs need to follow suit. Grad students- this is what your program looking out for you looks like. They aren't getting any extra $ for doing this, more than likely it comes from their grants. Still, it's the right thing to do.
We are raising base stipends in our
@MacBiochemGrad
program for all students by 20% to help mitigate the rising cost of living. By next year, this minimum will be over $31K for PhD students.
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Had the opportunity to meet Morgan and learn about her engineering approach this summer. She's very talented and so tenacious. Quite the deserved award.
Congratulations to Morgan Pugh-Toole at
@dalhousieu
for receiving a 2023/24 Doctoral Scotia Scholars Award for
#research
investigating the role for a natural killer cell-based
#immunotherapy
for high-grade serous carcinoma in an engineered tumor microenvironment.
🧵(1/5)
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Look at these wonderful faces! We've been so fortunate to work closely with
@ALK_net
and team on this paper. They're such a kind and intelligent team and doing incredible work in the allergy space. Thanks so much for this journey!
#PRESS
ALK and
@machealthsci
scientists have discovered 'the home of allergy' in the body. Their ground-breaking work has been published in the high impact research journal, Science Translational Medicine.
#allergy
#pharmanews
#pharma
#dkmedier
#research
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Thanks
@statnews
for the highlight of ours and
@MLafailleLab
's independent publications. A great and really well thought out piece that charts both group's trajectory with the project. Great work
@isabellacueto
!
Working with the cells of people with peanut allergies, researchers identify a "memory population" of immune cells that lead to allergic reactions.
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Further, why has the reaction evolved to be so violent? Aversion to taste makes sense to avoid a noxious substance, but what purpose could anaphylaxis have in this quality control system? (5/6)
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Deeply intelligent and insightful scientist talking about their area of expertise. Check it out!
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Tyrah was an awesome TA and will be sorely missed. Had a lot of fun playing with some uterus tissues with her as well. Huge congratulations, Tyrah!
Our amazing MSc student Tyrah Ritchie successfully defended her thesis yesterday! Here she is drinking out of the famous graduate chalice! Best of luck as she enters medical school at
@UTM
🎉
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👀 exciting things cooking
#Microscopy
Mosaic 🔬
[Allergic Mouse Intestine 1&9.DAPI 2.SMA 3.CD138 4.MHC-II 5&8.ST2 6.EpCAM 7.CD3]
#FluorescenceFriday
#Immunofluorescence
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👀Who are those two making discoveries?
@allyssaphelps
Researchers with
@MacDeptMed
have discovered a new cell that remembers your allergies.
@jfekoenig
@KellyBruton_
@ALK_net
@allyssaphelps
@McMasterU
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Darn
@CalmMcmaster
, something's cooking in your kitchen!
Imaging human
#tonsils
for the first time 😲
@zeiss_micro
@CalmMcmaster
Blue: DAPI
Green: CD3
Red: CD4
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@preprintclub
@MLafailleLab
@NatRevImmunol
@michelle_a_tran
@BerinLab
Also, thanks so much
@preprintclub
and
@michelle_a_tran
for the insightful critical appraisal of the work! It's given us a lot to think about for the future. I love what you're doing! (And thanks
@nkg2d1
for telling me about it!)
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We stand on the shoulders of giants.
@shlomchiklab
,
@bendall_lab
,
@R_JimenezSaiz
,
@DerekCroote
,
@MLafailleLab
, Menno van Zelm, Chris Allen, and Daisuke Kitamura for IgE and B cell memory work.
@ScottBoydLab
described switching pathways for human IgE. (17/18)
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IIDR is in great hands! Congratulations
@Millerlab_atMac
, very well deserved.
Please join us in welcoming Dr. Matthew Miller (
@Millerlab_atMac
) as our new Scientific Director!
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Great thread from Steve about his most recent work. We need to think more about NK cells in allergic disease.
1.We were broadly interested in what causes some children with atopic dermatitis (AD) to develop allergic and asthmatic disease (the atopic march) and are exploring potential mechanisms of this progression in a prospective early life cohort of children with AD (MPAACH).
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Ouch. Can I report this for directly attacking my personality?
Being an academic mostly involves saying “it will all calm down next week and I’ll get some proper work done”.
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This is huge for McMaster's very own
@RulloLab
. Congrats
@LabRullo
and
@BenjaminLake15
on this amazing work!
Tunable Multivalent Platform for Immune Recruitment to Lower Antigen Expressing Cancers (Rullo)
@LabRullo
@IBT_CAS
@WylieGroup
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@statfourwork
@KevinWNg
@Plasmacellguy
@DrJuanLMendoza
@slg1717
@KingOfPathogens
The IL-9 folks go hard.
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Congrats
@kcjorgensen
! Very well deserved. One of the best TAs I ever had in my immunology class and now doing amazing things in a great lab!
Congratulations to
@kcjorgensen
for winning the Polanyi Prize in Physiology and Medicine. 5 awards are presented each year by Nobel laureate Dr. John Polanyi. Thank you
@JillDunlop1
and Government of Ontario for the support.
@UofT
@uoftmedicine
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Arguably Seurat's most famous painting is called "A Sunday Afternoon on the Island of La Grande Jatte". This painting took Seurat 2 years to make, and its huge; 6.6 x 9.8 ft (2 by 3 metres). The work at the
@artinstitutechi
, same city as
@ImmunologyAAI
this year! 5/9
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Journal club material for any allergy researchers. Hygiene hypothesis has perplexed me for a while. Yet, microbial signatures are coming out of human trials constantly. What does it all mean?!
Check out our latest paper led by
@JunjieMa4
and
@BigEUrgard
, where we tested what impact a microbe-rich environment would have on immune responses to aeroallergens.
@NylenSusanne
and I teamed up with
@SRosshart
’s team who developed the wildling mouse.
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Mac's Biochem department is pushing science in the right direction. I'm continually impressed.
Are you an equity-deserving STEM undergraduate student interested in a fully-funded 12 week intensive summer research experience at one of the best Universities in the world? We got you.
@BBS_McMasterU
@McMasterU
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One of my awesome TAs for 3I03 is out here doing the most! Amazing
@Emily_YF_Feng
!!
#Superstar
Not 1… not 2… but 3
#CIHR
CGSD awards! Congrats to our PhD students
@Ana_LPortillo
@Emily_YF_Feng
@LizBalint
for their well deserved awards!
#AshkarLabCGSD
squad!
@MacImmunology
@machealthsci
@MacDeptMed
@Mac_HSGS
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@AdrianoAguzzi
We had a similar situation happen with mice a few years ago. I like the way it was handled- mice went to both groups with the broad warning "someone else has asked for these reagents for the same purpose."
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AWARD WINNER!
@VOlyntho
brings it in with her graphical abstract! Amazing work
#superstar
#PereySymposium2022
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This was published today! Congrats
@florsheim_eb
,
@RMedzhitov
on your beautiful paper. Cannot wait to read it and see the changes in the final version!
Super cool preprint from
@florsheim_eb
+
@RMedzhitov
! Mice are averse to eating allergens they are sensitized to, and there’s a neuro-immune explanation! Clinicians tell me all the time that kids significantly dislike the taste of their food allergen. (1/6)
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@MacImmunology
@MSU_McMaster
@machealthsci
Thank you MIRC! Also thank you to the 3I03 TAs!
@Emily_YF_Feng
@_sudeshnadhar
@hannambam
@allyssaphelps
& many more
1
0
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Super engaging talk from
@StephanieEisen
at
@MacImmunology
IIP seminar. Love her passion and the way she thinks about allergy/immunity!
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It was such an incredible pleasure
@JenGommerman
. Such an amazing talk, and thanks for your insight on our work! Mac was lucky to have you, and I can't wait until we get to bring you back!
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Special shout out to Vi for the poster and much of the data!
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Thanks for having me Rick! I love your studio space and your great energy! I'll be tuning in more often.
Great discussion with
@jfekoenig
from
@McMasterU
on Good Morning Hamilton on
@AM900CHML
about his discovery of MBC2. More details here
#allergies
#HamOnt
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I really like this piece!
Me, as I did my usual morning sneezes and reached for the allergy pills: "Ah, yes, that must be the IgE."
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Memory NK Cell...
@Ashkar_Lab
would be all too happy to see this.
Icebreaker activity for CSI attendees but also all our tweeps! Pick your birth month and number to find out what immune cell you are... do you actually exist?!
#CSI2022
🧫🦠🔬🧑🔬
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@KingOfPathogens
@statfourwork
@KevinWNg
@Plasmacellguy
@DrJuanLMendoza
@slg1717
Also I was too late to save my poor IL-4. Expelled like a parasite 😢
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Every year I give guest lectures. Every year, looking at the crowd, students look like they're bored out of their minds. Every year, students tell me they loved the lecture. Why am I so bad at evaluating enjoyment in real time?!
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If you're using mine and
@JustinTaylorLab
's tetramer protocol and you're fighting with a protein that likes acidic pH- we've found that the SA-APC that we use can be exchanged into pH 4.7 and stays fluorescent. A protein that aggregated at neutral pH polymerized well at 4.7!
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It was such a pleasure to have you. Amazing talk! I'm on the
#theonlylabever
bandwagon!
Had a wonderful day
@MacImmunology
yesterday. So great to catch up with the MIRC crew and to make new friends. Special thank you to the fantastic trainees and
@jfekoenig
for hosting. 😘
#theonlylabever
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My good friend
@SG_ChildHealth
tells me to tweet it or it didn't happen. We're demo-ing a very fancy
@LeicaMicro
microscope for the next week for our multiplexed imaging!
@VOlyntho
had some great images today!
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Ok, so
@GuzzoLabUTSC
is bad.ass. Awesome scientist and even cooler person. Thanks for the stories and advice! How did I not know sooner?
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This was such a brilliant talk. Judith is thinking differently about immune problems. So cool!
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The excitement when your optimizations finally work!! 🥹
@CalmMcmaster
#nasalpolyps
#immunofluorescence
#microscopy
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Big hard thing finally done. Sorry to everyone waiting on emails from me...
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From those anecdotes, this can sometimes be the difference between staying on allergen immunotherapy and ceasing. We know that most who cease will relapse into clinical allergy. This relapse is very likely due to memory responses that reconstitute allergen specific IgE. (2/6)
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@stephanielangel
So many circulating B cells (not PCs) express J chain... And most are not IgA... Saw this in our single cell work time and time again but never had much of an interpretation. Thanka for sharing this, I can't wait to read.
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Wooo! Congrats Sophie!
We are delighted to announce that our PhD Candidate, Sophie Poznanski, is now newly minted Dr. Poznanski! Sophie successfully passed her PhD defence on Friday with flying colours! Congratulations Dr. Sophie Poznanski, the lab truly won't be the same without you!
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Food allergy is often considered a misplaced immune response against innocuous foods, but in that case why have we evolved to have an IgE-mediated mechanism that dissuades consumption of a food? (3/6)
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@HaleyZubyk
made me the cutest stuffed cell! Hurray for office decorations! It's been such a great term teaching with you in cell biology so far!
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Have a great time! In person again is so fulfilling. I'm sure amazing ideas will emerge.
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Tour de force from
@MazDivangahi
. Such a unique thinker, but makes it seem like the ideas are only logical. The work is so clear, the experiments well designed, and succinctly explained. Blown away.
#PereySymposium2022
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@samworkenhe
@sci_questions
You're both stellar, regardless of these rejections. It's very reassuring to see folks I look up to struggling with the same things that I stress about. Thank you.
1
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@Plasmacellguy
I suspect that
@LabPhan
would have done it in some of his beautiful intravital stories.
1
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Just me re-advertising working with one of the best in the B cell business. Top mentorship quality, opportunities in abundance, proven track record with trainees. The whole package!
The Taylor Lab @ UVA will be hiring for the fall! The lab postdoctoral fellowship program will continue, and the professional development components have been extended to the entire lab. So reach out if you want to be in a lab that plans for your success with us and beyond. (4/4)
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And here's the other one, very relevant for my cancer immunology friends
@LabRullo
@sheilasinghlab
@Ashkar_Lab
Sharing two new preprints using our LIPSTIC technology to find DCs that prime CD4 T cells in two very different (and important) immune settings. This 🧵 is on a study led by
@AlexChudnovskiy
(🇺🇦🇺🇦) on the priming of a CD4 T cell response to cancer. 1/n
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@TheBrysonLab
@JustinTaylorLab
can probably help you get in touch with the folks from the Spanier et al paper that was shared above. Justin and/or I have some of the tools to help but probably far easier done with Brian et al at UM.
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@KevinWNg
@KingOfPathogens
@statfourwork
@Plasmacellguy
@DrJuanLMendoza
@slg1717
I'm sensing a certain GC-ness to your preferences! (which I wholeheartedly approve of.)
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This is a great opportunity with a great mentor! Dr. Justin Taylor has helped us tremendously; he's an incredible collaborator. You get it all here- visionary science, very competitive pay for an academic PDF, career guidance, and someone who will provide their support long-term!
We proudly announce the Innovation Fellowship, an approach to better support & train
#postdoc
for success in the Taylor Lab, and beyond. We aim to recruit 2-3 fellows at or above the high end of a $60-72K/year salary range. Apply now & please RT!
(1/5)
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2
0
3