Additional credit to multiple members of the Matsen, Victora, and other labs, especially @GallowayJared for coding; @tylernstarr and @jbloom_lab for deep mutational scanning; @WardLab1 for cryo-EM; and @TheArmita and @yun_s_song for help with math modeling.

We took this idea seriously and applied it to germinal centers, evolving the same reaction over 100 times. No spoilers here, though I can tell you that the amount of data is huge, and some of the findings were pretty surprising. Please check out the preprint!.

In his book Wonderful Life, Stephen Jay Gould proposes a thought experiment where one would replay evolution on Earth many times from the beginning, so as to find out what features would emerge reproducibly and which ones were contingent on historical accidents

Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by Will DeWitt (UW) and Tatsuya Araki and Ashni Vora (our lab), in a very close wet-dry collaboration with @ematsen ’s lab at the Hutch.