MariaLafaille Lab
@MLafailleLab
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IMMUNOLOGY OF ALLERGIES, IgE BIOLOGY AND B CEL MEMORY. Opinions are Maria's own.
New York, USA
Joined January 2023
Extreme budget cuts for science in Argentina can put in peril generations of scientists.
nature.com
Nature - Javier Milei’s actions after taking office have research institutions facing shutdown.
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RT @hernandezmsilva: It’s a huge honor to receive this year the MIT Martin Luther King Jr. Leadership award and could not agree more with t….
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Dear Dusan and Dusanites colleagues: we will miss you big time!!! Best wishes as you move to the other side of town. @BogunovicLab.
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RT @BogunovicLab: It’s been 10y since we opened our lab at @IcahnMountSinai. What an exciting ride and supportive environment it has been.….
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New work from the Victora lab (@victora_lab) explains why in secondary immunizations, new germinal centers form from naïve cells that bind poorly to the antigen. It’s all about pre-existing antibodies!
biorxiv.org
Re-exposure to an antigen generates serum antibody responses that greatly exceed in magnitude those elicited by primary antigen encounter, while simultaneously driving the formation of recall...
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Results of the first stage of the NIAID funded CoFAR OUtMATCH trial, involving 10 sites including Mount Sinai (Scott Sicherer, PI) were just reported
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Important news for pediatric food allergy!! The FDA approved anti-IgE (Omalizumab) treatment to reduce reactions to accidental exposures to allergenic foods. More in
nih.gov
Drug can help protect kids with multiple food allergies during accidental exposure.
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RT @NEJM: Original Article: Omalizumab for the Treatment of Multiple Food Allergies . Editorial: Options for Multip….
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RT @ScienceTM: This week's new issue of #ScienceTranslationalMedicine has arrived! Researchers uncover stealthy immune saboteurs that drive….
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Therefore, the findings described in our new @ScienceTM manuscript link these Type 2 IgG memory B cells to the production of peanut allergy-causing IgE antibodies, an important discovery for understanding and treating #FoodAllergy. 5/n
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When we isolated the cells that directly bind the main peanut allergen Ara h 2, we found that they belong to the Type 2 IgG memory cells, they contain clones that are similar between different individuals, and they produce antibodies that bind Ara h 2 with high affinity. 4/n
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The population of CD23+IgG1+ memory B cells from highly sensitized peanut allergic children contain peanut specific clones and generate IgE plasma cells upon activation. 3/n
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Food allergies are caused by IgE antibodies, but the role of B cell memory in persistent IgE responses is unclear. We now show in pediatric peanut allergy that CD23+IgG1+ memory cells are key players, they are increased in allergic children and correlate with IgE. 2/n
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Check out our paper in @ScienceTM with insight into how B cell memory for allergen-specific IgE antibodies is stored in CD23+IgG1+ memory B cells in kids with peanut allergies. Similar findings in pollen allergy reported in the same issue by @jfekoenig 1/n
science.org
A population of IgG+ memory B cells in peanut-allergic individuals contains high-affinity allergen-specific clones and is poised to switch to IgE.
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Our new manuscript on by Miyo Ota, Ken Hoehn and collaborators reveals the importance of type2-marked IgG memory cells in food allergy persistence. @SinaiImmunol @hoehnousk @skeinstein.
biorxiv.org
Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell memory of persistent IgE responses. Here we describe in human pediatric peanut allergy CD23+IgG1+...
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B cells in Aranda et al.:In addition to revealing the type2-marked IgG memory B cells, our manuscript has nice scRNAseq analysis of human blood B cells (naïve, memory and plasma from blood of adult atopic and non-atopic subjects. Check it out! @tonestrife @edgarEGK @SinaiImmunol
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