Anthony Rullo: chemically modulating proximity
@LabRullo
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Covalent and multivalent - proximity inducing strategies for basic and translational chemical biology
Joined June 2019
Chemoselective Tagging of Protein Methacrylation | Journal of the American Chemical Society
pubs.acs.org
Protein lysine methacrylation (Kmea) is a recently identified post-translational modification whose biofunction remains poorly understood. Until now, there has been no chemical labeling method for...
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Imine-linked covalent organic frameworks: Recent advances in design, synthesis, and application @COF_papers @MOF_papers @Molecular_Cages @POC_Papers
https://t.co/9S6208sJw9…
Imine-linked covalent organic frameworks: Recent advances in design, synthesis, and application @COF_papers @MOF_papers @Molecular_Cages @POC_Papers
https://t.co/VICqZa5FR0
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Excited to share our review on Induced Proximity-based therapeutic modalities now out in Nature Reviews Drug Discovery!
nature.com
Nature Reviews Drug Discovery - Induced proximity modalities encompass monovalent and bifunctional agents, such as molecular glues and proteolysis-targeting chimeras, that induce an interaction...
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🎉 New paper in Drug Discovery Today in collaboration with the Tuveson lab. “Clickable Covalent Metabolite Mimetics (CoMMs)” – nature-inspired scaffolds. Big congrats Elliot, Dharmendra, Shoujun & Adam! 🔗 https://t.co/yr5MQ4N4vh
#DrugDiscovery #CovalentDrugs #ClickChemistry
lnkd.in
This link will take you to a page that’s not on LinkedIn
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Great chemical review on induced proximity in the context of cellular immunotherapy https://t.co/aaVb51uGNp
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Specific binders to peptide–MHC class II are rapidly generated without laborious screening https://t.co/V7N6AGYPtV
https://t.co/UwDJy4S8Sh
nature.com
Nature Biotechnology - Specific binders to peptide–MHC class II are rapidly generated without laborious screening.
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With gratitude to reviewers, we are thrilled to report on a new type of hybrid drug: Baited SELEX: Drug-Directed Selection of Aptamers to PSMA for In Vivo Targeting of Prostate Cancer in Mice https://t.co/LusaluC1ND
@PCR_news @BeatPCa @prostatecanada @PCFNews @AptamerSociety
pubs.acs.org
We report a selection strategy for linking a drug-pharmacophore to a degenerate DNA library for use in cell- and whole-animal systematic evolution of ligands by exponential enrichment (SELEX) to...
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Development of Dual-Receptor Lysosome-Targeting Chimeras for Protein Degradation | Journal of the American Chemical Society
pubs.acs.org
A growing array of lysosome-targeting chimeras (LYTACs) have recently emerged as therapeutic candidates to treat malignancies and other diseases via targeted protein degradation. We established a...
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"We used a very low dose, almost 100 times lower compared to the traditional small-molecule drug, and the ABC still can achieve much better efficacy compared to the small-molecule drug given on its own," says @chemistrymit postdoc Bin Liu
news.mit.edu
Using nanoparticles shaped like bottlebrushes, MIT chemists can deliver a large range of chemotherapy drugs directly to tumor cells, which could reduce the side effects of treatment.
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A new generation of radiotherapies promises a more targeted attack on cancer. Learn more: https://t.co/chj1i58jEe
@NewsfromScience
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How to make immune cells “invisible” to facilitate allogeneic cell therapies? MIT and Harvard Build “Invisible” Immune Cells That Obliterate Cancer
scitechdaily.com
MIT and Harvard scientists have created engineered CAR-NK cells that can hide from the immune system and more effectively destroy cancer. The cells are designed to suppress immune-rejection signals...
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Happy to share my lab’s work out today in @Cancer_Cell demonstrating that multiple myeloma relapses after CAR T therapy frequently express low BCMA levels. We develop novel SEMA4A-directed CAR T cells eradicating MM, especially under BCMA low conditions. https://t.co/cgGMkh7GIy
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Controlling the 3D structure of #glycans allows increased binding to proteins- not just a curiosity but a powerful concept to develop better #vaccines
Stapling of β-Glucans Increases Antibody Binding | Journal of the American Chemical Society @peterseeberger @MpiciPotsdam @FU_Berlin
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Today's Nobel Prize for Physiology or Medicine relates to research on regulatory T cells https://t.co/rUp92Opbx3 For readers interested in harnessing the biology of regulatory T cells to treat disease, here's a comprehensive review https://t.co/4CVfcN5Y2r
https://t.co/z83V1d8cOQ
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Immunology takes center stage again at the #NobelPrize! Congratulations to Mary Brunkow, Fred Ramsdell & Shimon Sakaguchi for uncovering how regulatory T cells maintain immune tolerance—a discovery that transformed our understanding of autoimmunity and cancer immunotherapy
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Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes
nature.com
Nature Communications - PROTACs induce degradation by bridging a target protein and E3 ubiquitin ligase. Here, authors show that protein interface frustration correlates with cooperativity,...
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The fusion of intrinsically disordered regions to CARs enhances CAR-T signaling by inducing CAR condensation and enhances CAR sensitivity to low-antigen-expressing cancer cells https://t.co/9kvMmpxfNA
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