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@findboundary
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neuroscience, optimism. @join_polaris fellow.
London, England
Joined January 2017
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@metakuna
‘average ferry kills 3.17 passengers per billion miles’ actually just statistical error. average ferry kills 0 people. Charon the ferryman who lives in Hades is responsible for billions of deaths and should not have been counted
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Do you want a European economy based on public goods with no room for private enterprise, or an American one where the public domain is bankrupted for private benefit? Friends, there is a third way.
#anglofuturism
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@TylerAlterman
I saw one as a child and it was momentous. Go somewhere out in the open with lots of other people.
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@melodaysong
Doing inner work is not typically considered a basic need. Having friends is. Simple answers are sometimes the best!
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@GeorgeMonbiot
@ThosVarley
Well done for completely misunderstanding “psychosomatic” as a designation and continuing to propagate a harmful myth! Something psychological is not unreal, nor is it stigmatising in the mind of anyone except the patients.
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The first term of
@join_polaris
has been one of the most inspiring and optimistic experiences of my life. I wake up every morning believing that everything can be better, and trusting the people I've met to take us there.
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Muted this yesterday, the legions calling me names got old quickly. Worth saying again: there is no known disease pathology in ME/CFS, only symptoms.
Now, It's entirely valid to explore pharmacological routes to treating those symptoms for people who are suffering, but it
@GeorgeMonbiot
@ThosVarley
Well done for completely misunderstanding “psychosomatic” as a designation and continuing to propagate a harmful myth! Something psychological is not unreal, nor is it stigmatising in the mind of anyone except the patients.
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Neuralink is doing a good media round right now, but they're far behind the state of the art in interfaces.
Here's a prosthetic hand wired up to a BCI 4 years ago.
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warms the heart to realise that training 175B parameter language models requires a type of grit immediately recognisable to 90s hackers trying to get an extra 512mb of RAM to work in their PC
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@ruth_hook_
in fairness the concept of a psychology “lab” is fluid enough that you really can just speak it into existence
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@lookoutitsbbear
i'm a neuroscientist and i hope they include what you're doing in ephys tutorials one day, please keep going
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@pfau
I don't think this is the final word on this at all, but we're learning more about how reward systems track hunger, thirst, etc:
There's a good line of pioneering work throughout the last decade building up the methods to target hunger and thirst
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@ellegist
It's precisely the opposite of what the quoted tweet imagines: there's a peptide called orexin which regulates both emotions and wakefulness.
The full story isn't worked out as far as I can tell from a quick literature search, but probably aversive emotions create sleep
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A really nice look at how dendritic compartments can function as the missing 'error units' in hierarchical predictive coding:
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@eigenrobot
At the risk of being a little on the nose: ‘All that is solid melts into air, all that is holy is profaned, and man is at last compelled to face with sober senses his real condition of life and his relations with his kind.’
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@yuanyi_z
The single most diagnostic fact about New Labour's influence on political presentation.
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As I wrote over the weekend, there's a lot of harm in a diagnosis. It can easily become the mechanism sustaining the symptom.
Masochism is a key psychoanalytic concept
One form is victim entitlement—insistence one is entitled to special compensation in proportion to suffering & victimhood. Thus the need *to amplify suffering* in all ways
Without treatment, suffering & victimhood becomes a way of life
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@TiltingatM3
@rkidp
@GreySmithereens
@UrbanLandRent
I just went looking for this and found Graeber’s reply quite interesting:
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@qorprate
anecdote confirming this: the relatively healthy mental health discourse using phrases like "i'm stuck in a local minima"
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@nickcammarata
funnily enough, in practice this is how neuroscience was done in every institution I ever worked in
like 2-3 months convincing ourselves of the thing, ~1year+ putting it into whatever framework the audience need to hear
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@dwarkesh_sp
What does Tony think about Anglofuturism?
Poundbury, 2030
- You wake up
- Lab-grown full English for breakfast, served by robot butler
- Walk your children (which you can afford, because the housing crisis has been solved) to school
- HS22 takes you direct to Spaceport Cornwall, which can sustain heavy-lift launches
-
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@iotambat
another way to look at this is how thin your professor’s understanding of their field was
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@Aella_Girl
Conservatism has been theorised as a buffer against harshening conditions, since it tends to imply everyone gets what they deserve. See for example:
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People are saying this will be the beginning of England's greatest century.
Under Anglofuturism, low-earth orbit will be populated by thatched pubs. Because sound does not carry across the void of space, there will be no reason for restrictive licensing laws, and visitors will be able to drink for as long as they wish to
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@ctjlewis
people hear this as “literally a Von Neumann architecture” and not “does computation”
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@awaisaftab
@dost_ongur
This was a fantastic read. Particularly pleased to see Wittgenstein referenced, “classifications made by philosophers and psychologists are as if one were to classify clouds by their shape” — wise as ever!
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We're going to find out that a huge amount of behaviour labelled as autism spectrum disorder is not immutable, not divergent brain development, but simply a failure to learn social cues which is easily fixed with the right stimulus.
Do you think Empathy, MDMA & 5-HT or Autism are interesting? Here is a🧵about our NEW PAPER! w/unpublished data & insider tidbits!
Thank you
@dr_brein
@Jie_Neuro
@parnazboroon
@TheBorisLab
@mCherryGarcia
& twitterless colleagues
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@MajmudarAdam
this is great. strong agree with “early papers seem to intentionally feel pressure to fit ideas into neuroscientific and biological justifications” – taking those papers at face value is a footgun for bad historians of the field
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@EikoFried
@pimcuijpers
This is one of the most impressive tools I have ever seen in the open science ecosystem for psychology. Is there a plan for maintaining it in the future? (e.g., somewhere to donate, open source, grant)
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With thanks to the people quote tweeting me to say I’m fabricating claims of harassment, and they’ve checked every reply. A sample:
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@nickcammarata
and really this speaks to the way in which theories act more as interfaces than explanations
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@ctjlewis
yeah, the “nooooo it hasn’t really learned the rules” thing seems like huge cope when it’s unclear humans ever learn anything like that — just sufficient scale to better avoid mistakes (but still some errors!)
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lot of cowards won’t read this because it’s girl coded but let me tell you this is science fiction horror of the highest degree
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ChatGPT what is the color of the middle square in each of these pictures?
A: Blue and Yellow
that's what happens when you compare patches i guess?
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@WiringTheBrain
Human participants choose options which maximise the number of future choices they can make: (2023)
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@BenRatkaj
there are better versions of this technology already discovered!
bigger question is how you move beyond motor interface - decoding motor planning signals from
the brain is fundamentally a lot easier than most other things
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Dopamine as the pleasure molecule is such a boring story. Dopamine is the hypothesis molecule, delivering hallucinations and motivation. How do you tell the difference? Is there one?
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Antidepressant prescribing increased by 66.3% in the 6 years between January 2016 and December 2022, mostly driven by prescriptions to females aged 12 to 25.
The rate of antidepressant prescribing to girls under 18 increased 129.6% from March 2020.
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@cremieuxrecueil
They are transparent about this in the original study. It's useful for generating better studies, I don't think you can walk away assuming it's a big pile of nothing.
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marriage rates 📈
GDP 📈
anglofuturism secure
trust the plan
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@statsepi
I think everyone involved is getting what they want in this situation. Nothing to see here.
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On going in search of organic pathology explaining psychological symptoms: “I spent 13 years at NIMH really pushing on neuroscience… and when I look back on that I realize that while I think I succeeded in getting lots of cool papers published by cool scientists at fairly large
"Real psychotherapy is not about DSM diagnoses and never was. Real psychotherapy outcomes are not reducible to DSM symptom lists."
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@KordingLab
There are many moderating variables (eg, therapist empathy, alliance with patient, belief/investment in therapy) which make a headline figure like this inappropriate. “psychotherapy” - you might as well estimate the effect of “drugs”
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In mice, an overactive threat detection system is responsible for anorexic behaviour.
Does this tell us something about the relationship between anxiety and anorexia?
Read on to find out how ↓
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@ellegist
Interesting bias. One explanation: larger head circumferences are known to be associated with resilience to brain pathology and injury, i.e, even with brain damage you can function relatively normally. Thus, selection effects at work. Everyone on this part of Twitter is
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@kasratweets
@brianbrianmuh
we're never getting anywhere talking about the efficacy of "psychotherapies" — efficacy is different for each, e.g.,
therapists play a big role in success, and we're starting to understand how much and why
error rates from leaving therapist effects out of a model:
some
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We can rephrase explanations like this in terms of measurable quantities.
Mark describes patients who experienced early life as uncertain. Sound familiar?
Picking fights is a way to gather evidence, so if you tend to be uncertain you’ll be motivated to pick more fights.
High-conflict personalities--usually those with Cluster B disorders--routinely "pick fights" or "stir up" conflicts in interpersonal relationships. This behavior mirrors the early environment of the patient, which was fraught with conflict, and is a form of repetition compulsion.
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@GeorgeMonbiot
@ThosVarley
Contrary to your claim, the condition is not widely recognised as a physiological disorder. Treatment guidelines have changed in response to patient distress, which rather undermines your claim this is a story about an intransigent medical establishment.
Moreover, a proposed
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@ThosVarley
@GeorgeMonbiot
The “psychosomatic” model (to the extent that’s a reasonable way to refer to it) doesn’t imply no physiological symptoms. You can find plenty of physiological changes in depression, ADHD, take your pick.
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@pfau
Not my field, but there have been breakthroughs in cancer biology showing how the nervous system is involved in regulating tumour growth and much else.
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@neuroecology
Does systems neuroscience have conceptual advances? 1-3 were existing concepts — though the evidence in favour is of course new
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@ThosVarley
@GeorgeMonbiot
I was on board until you suggested the failure of CBT is enough evidence to reject psychotherapy entirely!
There’s nothing here that doesn’t also apply to SSRIs for MDD: it will help some people but not others, the treatment will introduce new problems, and we’re in for a few
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Phrenology never went away.
A new neuro-morality doing the rounds on TikTok....
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@nEquals001
@ctbeiser
@michael_nielsen
@andy_matuschak
exactly, this is the strong version of “tools for thought” but somehow it always ends up being a note taking app
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@cremieuxrecueil
Though, following this report, the Civil Service removed cognitive testing in favour of situational awareness tests:
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Two weeks to the next in this series of London talks, which covers embodied cognition:
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@ellegist
more prefrontal cortex in a more effortful task is not news and glutamate can just be a measure of task-related activity – the link between glutamate and fatigue is a leap
(their logic: working harder in the gym burns calories and makes you sweat, therefore calories cause sweat)
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A simple principle predicts the detailed structure of learning: birds learn to produce the average of the behavioral trajectories associated with successful outcomes.
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Intriguing case of brain fog, fatigue, dizziness, and patients with a deep conviction that there is a conspiracy against them.
New study finds no brain injuries among 'Havana syndrome' patients
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@ellegist
Yes, you're absolutely right. A broad definition of appetite keeps that etymology working. e.g., orexin pops up in addicts to drive drug seeking during withdrawal — certainly an appetite of sorts!
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@yacineMTB
ty for attracting so many bad arguments against this position so I can collate them. you will be remembered when the neurocratic future comes to pass
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new paper contending that most of the ways we measure the components of executive function reduce to speed of information uptake, in other words a noisy measure of IQ
emphasis on executive function as the real predictor of life success is probably overstated
also impactful for
It's out! 🤩 New paper led by my brilliant PhD student
@ChristophLffle2
, in which we show that individual differences in executive functions (updating, inhibition, shifting) measure nothing but individual differences in the speed of information processing:
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@pfau
@KordingLab
Last time I said something like this on here I got accused by faculty of saying Hinton et al. were "liars" – have fun!
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Contra this, finding changes in the brain ≠ you are looking at a brain disorder.
You can pump your intuition on this by thinking about alcohol abuse: drink a lot and you'll lose grey matter volume, slow neurogenesis, and likely end up having a stroke.
But the disorder which
For those arguing that schizophrenia isn't a brain disorder, it's worth reviewing this 2001 Thompson et al. study that found significantly greater grey matter volume loss from age 13-18 compared to normal controls after controlling for medication effects.
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this effect in full:
- significant difference apparent only in the disappearance of five unusually low data points from the placebo condition (circled on figure)
raw egg brain damage
Rub testosterone gel on a man's arm and he will, quite literally, stop engaging in deceptive behaviour because he has an audience ("strategic prosocial behaviour") and say exactly what he thinks and feels, regardless of what others think. Amazing, right?
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@93vintagejones
@ClarkeMicah
@Sargon_of_Akkad
“I want to share in Britain’s trials and tribulations because I need it, and it needs me.” Hear, hear!
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@bryancsk
makes my happy that they’re trying but neuralink is still behind SOTA as far as I can see, they’re just making nice product demos of existing things
interesting discourse around it because I don’t think people realise how much harder it is to get past this point
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@GeorgeMonbiot
@ThosVarley
Yes, I did that thanks. This is a hatchet job making a lot of out of fringe cases. Pushing for a new interpretation won’t change the fact that medicine sometimes fails, it will only relocate that failure from psychotherapy to biological interventions.
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What’s fascinating about this is it repeats centuries of confusion in philosophy of mind, when introspection was held up as the chief method of investigation.
Wittgenstein: “What we are destroying is nothing but houses of cards and we are clearing up the ground of language on
This is a fascinating conversation with a girl who lacks an internal monologue. She articulates the experience quite well.
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@mezaoptimizer
If? It was called the Fabian Society back then. And let me tell you, they were hard into eugenics.
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@lumpenspace
One of the very timely things about Dune being adapted for the screen is the concept of foresight emerging from advanced memory.
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@gershbrain
For anyone wanting to think functionally: (I consider working through this course one of the most useful things I have ever done intellectually!)
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@esfinn
This is great, the issue in the past was of course people making large claims in the title and abstract to sell these papers. N = 17 for "Validation of a scanning paradigm to test for [X]" is fine, "Localisation of decision making in PFC" is not.
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figure below is the ratings for photographs
you can ask why there would be lower attractiveness ratings for autistic people: my guess is because diagnosis is subjective and you’re more likely to get one if you don’t have the halo effect of physical attraction
but that’s left
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@micahgallen
is this “world famous cuisine” nutritionally complete and ready in under a minute? I didn’t think so
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