Eric Joyce
@ericjoycelab
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Associate Professor, @PennGenetics @PennEpiInst 3D Genome structure and function
University of Pennsylvania
Joined July 2017
🚨New preprint from the lab🚨 🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK. https://t.co/KGTUAZqHyS
biorxiv.org
The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their...
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We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs. Please share with colleagues who may benefit!
ericjoycelab.com
In an effort to make Oligopaint FISH probes more broadly available to the research community, we offer DNA and RNA FISH probe design, synthesis, and generation. By dedicating a full-time staff memb…
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Dr. Randi Isenhart (@isenhartrandi) has a new 1st author publication for her work in the @ericjoycelab on: The length and strength of compartmental interactions are modulated by condensin II activity:
journals.plos.org
Author summary The three-dimensional organization of the genome plays a critical role in regulating cellular function, yet the mechanisms that govern large-scale chromatin architecture during...
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We are deeply saddened by the loss of an esteemed colleague, friend, mentor & a pioneer in Drosophila & meiosis research. R. Scott Hawley was a dedicated supporter of GSA & a champion of genetics. Read an In Memoriam published in Genes to Genomes: https://t.co/Nabrvgthv7
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Exciting news 📃🧬🔬 Today we report on the dynamics of a fascinating class of molecular motors, so-called SMC proteins in @CellCellPress
https://t.co/MRIIHE893Z
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Excited to share our latest work on bioRxiv! Using cell-cycle dynamics and NIPBL depletion, we show that long-range enhancer interactions can form de novo without loop extrusion. Alternative mechanisms, including LDB1 and YY1, may play key roles. https://t.co/CgBN4QJcuL
biorxiv.org
NIPBL promotes chromatin loop extrusion by the cohesin complex until it stalls at convergently oriented CTCF sites, leading to the formation of structural loops. However, to what extent loop extrus...
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ft. @HarkeJailynn, Jeewon Lee, @SonCNguyen, Staci Rakowiecki, @rebecca_yunker, @doug_epstein, @ericjoycelab (@PennGenetics), Arian Arab, @Melike_Lak (@PennEpiInst) & @SHugelier (@UPennPhysiology) @MolecularCell
https://t.co/JP65evo2rD
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Our paper discovering a centromere-localized retroelement RNA is now out in @GenomeBiology 🎉! Transcription of this retroelement is higher in CENP-A chromatin where insertions of this element seem to occur preferentially. Pls check it out and RT!
genomebiology.biomedcentral.com
Background Centromeres depend on chromatin containing the conserved histone H3 variant CENP-A for function and inheritance, while the role of centromeric DNA repeats remains unclear. Retroelements...
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Congratulations @HarshiniChandr8 💐 Using human neurons homozygously-engineered with familial AD mutations, she found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs BioRxiv: https://t.co/JymYYJdcId
We are excited to announce the winner of the GOA Young TAD for 2024 is @HarshiniChandr8 🏆🥇🏅 Congratulations to Harshini and also to the other finalists! The 3D genome field is in great shape with so many innovative young scientists!
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It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
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🚨Inter-chromosomal contacts (‘kissing chromosomes’) organize human genome topology along a spatial gradient of genome activity (62 Hi-C datasets). Check https://t.co/a5izMPo6C4,
@NatureComms, @4DNucleome, @The3DGenome, @humangenomeorg, @netscisociety, @Emblebi, @MoGen_Grads
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Happy to share work with Hadi, Yao & @Maxime_Tortora characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion https://t.co/iiaiJg2ZeB
biorxiv.org
In mammalian interphase cells, genomes are folded by cohesin loop extrusion limited by directional CTCF barriers. This interplay leads to the enrichment of cohesin at barriers, isolation between...
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First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? https://t.co/l7bwPsTSkd (1)
biorxiv.org
Enhancers are critical genetic elements controlling transcription from promoters, but the mechanisms by which they convey regulatory information across large genomic distances remain elusive. Here,...
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Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? https://t.co/xKP9tGFFlQ
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1/🧬Does chromatin organization shape immune responses? Our recent study with @NickAdams_PhD led by Reizis Lab and @leonidmirny explores how cohesin, a key player in chromatin loop extrusion, controls the chromatin architecture essential for conventional dendritic cells (cDC)👇
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📣Sharing the latest research from the @MRSantosLab, just released on bioRxiv! We found LINE1 RNA promotes nuclear compartmentalization to repress the 8-cell state in human embryonic stem cells. https://t.co/uE06Xx3QcY 👇Key findings:
biorxiv.org
The family of LINE1 transposable elements underwent a massive expansion in mammalian genomes. While traditionally viewed as a mutagenic selfish element, recent studies point to roles for LINE1 in...
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We then show these changes are found within tissues and during aging. To learn more, check out our preprint! Thank you to all co-authors, the Buenrostro lab, and everyone at @HSCRB & @broadinstitute who made this work possible! https://t.co/sim05C81m0
biorxiv.org
Microscopy and genomics are both used to characterize cell function, but approaches to connect the two types of information are lacking, particularly at subnuclear resolution. While emerging multip...
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Speaker Spotlight: @MariekeOudelaar from the Max Planck Institute will share exciting research on the mechanisms behind 3D genome folding and its role in gene regulation during cellular differentiation. Don't miss it! Register here 👉 https://t.co/xHZSamYZuq
#chromatin2024
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Excited to see our paper officially out in the August issue of @CD_AACR !
Condensate-Promoting ENL Mutation Drives Tumorigenesis in vivo through Dynamic Regulation of Histone Modifications and Gene Expression, Yiman Liu, Qinglan Li, @LilingWanLab, and colleagues. @PennMedicine @PennCancer @PennEpiInst @Penn_CBIO
https://t.co/kp3WvDlgom
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