RT @resgen_io: Big update over the weekend: datasets can now be organized into folders!. Also, the default ordering for projects is by the….

Who is Pei Kib Breat? Left: peer-reviewed paper published in 2024, right: original paper in 1946 with image recognition problem. Is the 2024 paper AI-generated or just not fact-checked and proofread?.

9/🎉 A special milestone for me! We released this research a week ago, but today, I’m sharing it with you on a day close to my heart—my birthday! 🥳 Immensely grateful to my brilliant collaborators who helped bring this to life just in time. Couldn’t ask for a better gift!🎂.

8/🚨The big takeaway: cohesin isn’t just about genome structure—it’s an essential regulator of immune function, influencing how DCs fight pathogens and tumors. #ChromatinResearch.

7/ Coheins-Irf8 dynamic duo optimizes DC function by managing chromatin loops and compartmentalization.

6/🔬Cohesin complex doesn’t work alone in shaping the dendritic cells function. Transcription factor IRF8 ensures the proper chromatin organization, most significantly directing the compartmental switches of genes active in DCs and their activation.

5/🧪Mice deficient in cohesin show impaired IL-12 production and weakened anti-tumor responses, suggesting that cohesin is crucial for activating immune cells and proper cytokine signaling.🧫This could have implications for cancer therapies! My favorite figure by @NickAdams_PhD

4/ It aligns well with recent studies showing the role of cohesin in shaping promoter-enhancer interactions and counteracting the Polycomb repression!.

3/🌀Cohesin organizes chromosomes, but not only. In DCs, the response to the antigens is impaired without cohein! We figured out that genes that fail to get activated are those far (>100 Kb) from the nearest enhancers and more enriched in Polycomb before activation.

2/🦠DCs bridge innate and adaptive immunity. Surprisingly, strictly required factor for DCs to function is cohesin. Without it, cDCs fail to differentiate fully, but more critically, lose ability to cross-present antigens and secrete IL-12, a key cytokine for immune defense.

1/🧬Does chromatin organization shape immune responses? Our recent study with @NickAdams_PhD led by Reizis Lab and @leonidmirny explores how cohesin, a key player in chromatin loop extrusion, controls the chromatin architecture essential for conventional dendritic cells (cDC)👇.

RT @golobor: My lab is looking for PhD students with a background in physics and/or biochemistry/quantitative biology. If interested, ple….

RT @EcoRInya: Check out a recent review from the Larson lab, where Chris explores in depth how enhancers communicate with their target gene….

Excited to speak at the Genome Architecture and Function School and Workshop last week and introduce Hi-C analysis with @Open2C_team software and @trevmanz higlass-python version of amazing @higlass_io browser for Hi-C and other omics data.

RT @SchuhLab: Women are born with all their oocytes, which need to stay viable for decades to ensure fertility. How are they maintained for….

RT @OdedRechavi: No one knows how universities and the job market will look like 10 years from now but I'm starting to work on a course nam….

HoloView solutions may have a good solution buried there (I hesitate to use the Python visualization library whose developers have no intention to make their doc plots readable)

Proplot solutions (so sorry not to find a good map there, it's my favorite custom plotting lib)

other maps seem to attenuate the center: CMasher solutions