Great meeting on the spatial genome! Learning a lot and kicking off new collaborations!

tRNA-overlapping long non-coding RNA loci repress codon-biased genes

📢Paper Alert: https://t.co/VJOZKZyiGD. We characterized tRNA-overlapping lncRNA loci = tROLs! tROL perturbations silence codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding and coding genomes. @MoGen_Grad @SickKidsNews @SK_GGB @lncRNA_papers @CIHR_IG

See you in Mexico, 3D genomics aficionados!

Proud to see this work on a new #machinelearning model for #RNA structure, ECSFinder, now online https://t.co/oFjhOp8mg1 This work was led by @non_coding_gal , a PhD student co-supervised with @martinalexsmith at @ramacgenomics in collab with John Mattick. Full thread 👇🏼

📢Deadline extended! Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25 Final slots

Looking forward to a great conference about spatial genome structure in Mexico in Fall! Come and register! 🇲🇽

@KarimMekhail Please share with your followers and spread the word! @RogerRogergr @JumanaAHA @efapostolou29 @Samuel_Bakhoum @tonycesare4 @CreminsLab @CatherineFreud2 @taekjip @brokendna @LeungLab @MarinaLusic @PeterLyLab @NucleomeHunter @Kramadan2 @jesstylerlab 🇲🇽🌞

Great summary of our recent work on determining inter-chromosomal interactions across 62 diploid human genomes! THANK YOU!

What role do inter-chromosomal contacts play in organizing genome structure, and how can we effectively detect and analyze them across different cell types? @NatureComms @SickKidsNews @UofT "Inter-chromosomal contacts demarcate genome topology along a spatial gradient" • This

Perspective. Uncovering previously hidden patterns in the genome and understanding how chromosomes communicate in healthy and disease genomes is next. Big THANKS to the incredible team, to @ericjoycelab, Samin Aref, Thomas Liehr, Anja Weise, and to funding agencies! @CIHR_IG

New rules of genome topology. 61 ‘topological anchors’ occur across cell types at the speckles, where especially p- and q-telomeric contacts coalesce regions of highest gene density and transcription factor binding and synergistically shape genome topology by a spatial gradient.

Contradictory findings. Rabl’s configuration with extensive inter-telomeric and inter-centromeric clustering exists across human cell types. Despite recent findings, Rabl’s configuration and chromosomal territories may not be mutually exclusive.

Fundamental Properties. Recurrent inter-chromosomal contacts occur in gene-dense and highly expressed genomic regions that harbor cell-specific and sex-specific genes. Check your cell type of interest in Supplementary Data 3 & 4.

Data science approach for Hi-C analysis. Supervised & unsupervised learning (Community Detection) assess the Spatially Interacting GeNomic ArchitecTURE -> SIGNATURE, to confidently detect interacting and non-interacting regions between different chromosomes across 53 2n genomes.

🚨Inter-chromosomal contacts (‘kissing chromosomes’) organize human genome topology along a spatial gradient of genome activity (62 Hi-C datasets). Check https://t.co/a5izMPo6C4, @NatureComms, @4DNucleome, @The3DGenome, @humangenomeorg, @netscisociety, @Emblebi, @MoGen_Grads

Penn's Department of Genetics has several new tenure-track assistant professor openings. Please help spread the word! https://t.co/I4Ljo9WYu2

So happy to announce renewal of my Canada Research Chair in Non-coding Disease Mechanisms! Congrats to all CRCs & many thanks for all admin support. https://t.co/kjYUJmrEd6, @SSHRC_CRSH, @CRC_CRC, @NSERC_CRSNG, @CIHR_IRSC, @SickKidsNews, @SK_GGB, @MoGen_Grad NON-CODING FOR LIFE!

Congrats, Marta! Great news!

Cool research and great PI! Apply!