Looking forward to a great conference about spatial genome structure in Mexico in Fall! Come and register! 🇲🇽.

RT @Fusion_Conf: @KarimMekhail Please share with your followers and spread the word! @RogerRogergr @JumanaAHA @efapostolou29 @Samuel_Bak….

Great summary of our recent work on determining inter-chromosomal interactions across 62 diploid human genomes! THANK YOU!

RT @aipulserx: What role do inter-chromosomal contacts play in organizing genome structure, and how can we effectively detect and analyze t….

Perspective. Uncovering previously hidden patterns in the genome and understanding how chromosomes communicate in healthy and disease genomes is next. Big THANKS to the incredible team, to @ericjoycelab, Samin Aref, Thomas Liehr, Anja Weise, and to funding agencies! @CIHR_IG.

New rules of genome topology. 61 ‘topological anchors’ occur across cell types at the speckles, where especially p- and q-telomeric contacts coalesce regions of highest gene density and transcription factor binding and synergistically shape genome topology by a spatial gradient.

Contradictory findings. Rabl’s configuration with extensive inter-telomeric and inter-centromeric clustering exists across human cell types. Despite recent findings, Rabl’s configuration and chromosomal territories may not be mutually exclusive.

Fundamental Properties. Recurrent inter-chromosomal contacts occur in gene-dense and highly expressed genomic regions that harbor cell-specific and sex-specific genes. Check your cell type of interest in Supplementary Data 3 & 4.

Data science approach for Hi-C analysis. Supervised & unsupervised learning (Community Detection) assess the Spatially Interacting GeNomic ArchitecTURE -> SIGNATURE, to confidently detect interacting and non-interacting regions between different chromosomes across 53 2n genomes.

🚨Inter-chromosomal contacts (‘kissing chromosomes’) organize human genome topology along a spatial gradient of genome activity (62 Hi-C datasets). Check @NatureComms, @4DNucleome, @The3DGenome, @humangenomeorg, @netscisociety, @Emblebi, @MoGen_Grads

RT @ericjoycelab: Penn's Department of Genetics has several new tenure-track assistant professor openings. Please help spread the word!.htt….

So happy to announce renewal of my Canada Research Chair in Non-coding Disease Mechanisms! Congrats to all CRCs & many thanks for all admin support. @SSHRC_CRSH, @CRC_CRC, @NSERC_CRSNG, @CIHR_IRSC, @SickKidsNews, @SK_GGB, @MoGen_Grad NON-CODING FOR LIFE!.

Congrats, Marta! Great news!.

Cool research and great PI! Apply!.

Great retreat with awesome science, colleagues, and Benoit Bruneau from Gladstone Institutes!.

RT @benoitbruneau: Incredibly great time at @UofT Collaborative Developmental Biology program retreat and visit at @SickKidsNews. Thanks to….

Congrats Mitch & team!.

Congrats, more team efforts to come! 🥂.

DNA double-strand breaks are captured by nuclear envelope tubules to drive DNA repair! Check this great story out by @KarimMekhail lab and team: @SickKidsNews @SK_GGB @UHN @UofT @uoftmedicine.

Congrats, Mitra! Great to see the final print of this cool story!.