Elphege Nora Lab at UCSF
@ElphegeNoraLab
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Our laboratory seeks to understand how chromosome structure relates to genome functions Tweets by Elphege
San Francisco, CA
Joined December 2018
First preprint from the lab 🚨. How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process?. (1).
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RT @Dev_journal: Target gene responses differ when transcription factor levels are acutely decreased by nuclear export versus degradation….
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RT @MartyYang: Ecstatic to share the first story from my post-doc, co-led with Megan Ostrowski, out now in final form (.
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RT @jane_skok: Thrilled to share our new preprint, 'A genome wide code to define cell-type specific CTCF binding and chromatin organization….
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RT @QuintanaMurci: ‘Human Peoples’ is out @PenguinBooks.A genetic journey through how migrations, admixture (among humans and with Neandert….
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RT @NAltemose: I’m excited to share the first preprint out of the Altemose Lab! This stems from a heroic effort by Dr. Matt Franklin @matt_….
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RT @jrichardalbert: In short, we investigated the impact of DNA methylation (5-methyl-CpG) on 1. CTCF promoter-enhancer looping and 2. Poly….
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RT @m_alexanian: 🎉Excited to finally share that our new work (previously @biorxivpreprint) is now online at @Nature! A fantastic team effor….
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RT @Jesse_R_Dixon: It’s a bit belated, but I am happy to share the latest work from our group, led by a very talented post doc in the lab,….
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RT @Xingjie_Ren: We @YinShenLab are excited to share our work on the functional characterization of enhancers of neuropsychiatric risk gene….
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CTCF, just like any transcription factor, binds its target sites on and off. Turns out considering this dynamic is essential to explain chromosome folding patterns from Hi-C and microscopy, and how they rearrange upon tampering with cohesin. What an exciting manuscript! 👏.
Happy to share work with Hadi, Yao & @Maxime_Tortora characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion.
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RT @EddaGSchulz: 📢 New preprint from the lab! .CRISPR-screening wizard 🧙 🧬 @TSchwammle figured out how different signals 🚦 are integrated a….
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1 week left to apply to the open-rank faculty search for the UCSF dept. of Biochemistry & Biophysics. All area of fundamental biology are welcome. Reach out if you have any questions.
Our department of Biochemistry and Biophysics at the University of California San Francisco is recruiting tenure-track faculty. We welcome all areas of biology across models - from single molecules to organisms and ecosystems. Deadline Oct 15 2024.Pls RT.
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RT @pablonavarroLAB: After a massive team effort leaded by the incomparable @NicolaFestuccia I am really happy to share our freshly publish….
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@KarissaLHansen @dewit @geoff @RobertBlelloch @_RiniShah @Erikacander @LucaBraccioli @bffswithbiology (21) Oops, wrong X handle 😅.- meant to tag the one and only Geoff Fudenberg @gfudenberg for key contributions to the transcriptomic analyses and stimulating ideas.
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@KarissaLHansen @dewit @geoff @RobertBlelloch (20) Additional authors on X: @_RiniShah @Erikacander @LucaBraccioli @bffswithbiology @RobertBlelloch.
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19) This was a heroic effort by graduate student.@KarissaLHansen, who created more engineered cell lines than we can count with the help of genome editor extraordinaire Annie Adachi, and many wonderful collaborators in our lab and in @deWit, @Geoff & @RobertBlelloch groups.
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(18) How does the SRR2 work to boost the effect of distal enhancers? Condensate biophysics? Unknown looping factors? 🤷. How can we hunt for similar elements across the genome & across cell types? 🧪🧬❓. We would love to know – check out the paper for some discussion.
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(17) So it’s not that complicated in the end:. If you rely on an enhancer, you will need cohesin extrusion beyond ~18kb. UNLESS you have a promoter-proximal regulatory element that can synergize with your distal enhancer – which happens independently of cohesin.
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(16) Why? Quite simply, you have now removed the two redundant axes that support long-range enhancer action at Sox2.
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