Todd Douglas
@ToddDouglasPhD
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· Postdoc @ Yale (MCDB) studying cell death x metabolism x ubiquitin interplay · climate justice now · he/him
Joined April 2020
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grateful for receiving a "best poster presentation" award at this year's
@YalePostdocAsso
symposium!
🚨Congratulations to all the Winners! Thank you so much for your wonderful work 🎉🙌🏼
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@DrBenNeel
@bariweiss
Hi Dr. Neel, nice buzzwords - would you care to elaborate on how this is a "McCarthyist witch-hunt"? A third-party law firm conducted the investigation and found him to be guilty. That is due process. That is justice. What exactly are you "disappointed" and "frightened" by?
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Wanted to share some thoughts on something really important to me and all of us. Don't have a lot of followers, but if you see this I'd appreciate a read.
A thread: (1/12)
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@normalbitch96
This is personally offensive but I don't disagree. You just know she was a couple years shy of dying her hair purple.
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Feeling a rare but healthy dose of pride today - reached a personal milestone of 500 citations! Grateful for all the co-authors + exciting science I've gotten to work on. Lots more to come!
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Happy to have played a small (but important!) part in this. My first Crews Lab paper, 5th author or not -- check it out!
Excited to see another of my thesis chapters published. We developed a DcpS degrading PROTAC, with implications to better understand AML and SMA biology. Thanks to everyone who made this possible.
@CraigMCrews
@ToddDouglasPhD
@MattSimonLab
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@JohnFetterman
This is an exceedingly rare, singular case where I have to side with Oz on this one. Meat production is incredibly detrimental to the environment and our health and he's right that it should no longer be subsidized by the government. Higher prices would dissuade consumption.
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choosing what albums to listen to during tissue culture feels like the most important decision of my day
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Western blots should not be quantified.
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In the past four months alone four papers came out - all in good journals - that nicely corroborate findings from my 2019 paper. Hate to be petty, but it's a pretty small field and none of them cited our work. Love it!!!
I should get used to this, shouldn't I?
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GSDMD-dependent necroptosis? I wish Jurg Tschopp was alive to witness how complicated the inflammasome/cell death field has gotten.
Now online! Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis
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me, a third year postdoc writing a proposal for my future lab
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last year I spoke at a press conference urging CT politicians to block the building of the proposed Killingly Energy Center gas power plant -- just found that I was cited by
@SierraClubCT
..cool!
(they misunderstood my Dr. title, but eh)
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Support a great cause! Check out or
@desk_nhv
for more info on how to help out the New Haven community, and follow us at
@YaleBPA
to find out about more Black postdoc-led initiatives.
Despite the snow, my son and I had a great time volunteering with
@YaleBPA
to package/distribute food with
@desk_nhv
! Our co-outreach chair
@ToddDouglasPhD
is planning to do this again, so please join us! Or learn more about the great work they are doing and how to help!
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calling on the
#celldeath
community to appropriate "rapid unscheduled disassembly" when discussing necrosis
The biggest and most powerful rocket ever built, Space X's Starship, launches in Texas before a "rapid unscheduled disassembly" during ascent
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Today marks exactly 10 years since I ran my very first Western blot. What a ride it's been. Hell and back. Cheers to 10 more!
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babe wake up a new programmed cell death modality just dropped
New molecular details of
#cuproptosis
, an emerging form of cell
#death
mediated by
#copper
, mitochondrial respiration, and proteotoxic stress.
Work
@ptrtsvetkov
and Todd Golub
@broadinstitute
.
@ScienceMagazine
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ouch my heart... thank you, Nadia, for showing us how to leave this weird place with grace and courage. powerful. beautiful.
❤️
@DrNadiaChaudhri
passed away yesterday evening, having reached the end of her road with ovarian cancer. She leaves behind her Sun and Moon, a loving extended family, colleagues and students, friends around the world, and so many others who have been touched by her & her story 1/n
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Congrats to
@JasonHu222
and Po-Han on their latest story where they develop and implement an approach to induce targeted dephosphorylation of tau using heterobifunctional small molecules! Happy to have contributed.
Excited to share our Tau PhosTAC paper on
@J_A_C_S
. PhosTAC provides a new modality for neurodegenerative diseases treatment. Many thanks to
@CraigMCrews
, and the awesome team Po-Han Chen, Wenxue Li,
@ToddDouglasPhD
, John
@Yanshen73854711
🎉
#PhosTAC
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Deeply disturbed. The past few months genuinely make me want to abandon my career. I don't understand what this is for. There is an ongoing genocide and the majority of my peers active on this site, scientists whose work I respect, have not publicly expressed any feeling
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We all need a friend like the selfless macrophage: "hey bro, I know you hurting rn...here, take these"
?
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@GovNedLamont
Governor, if you want a carbon-free future in CT why did you do nothing to stop the frack gas plant in Killingly from being approved? There is absolutely no reason to be building new gas power plants in 2021.
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when I'm a PI I'm going to make sure all my trainees know there is only one (1) way to use pipette tips and it's right to left, bottom to top. anything else is simply bad science.
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New paper feat. twitterless labmate Mack Krone on the development of engineered chromodomains as tools to detect methyl-histones (superior to Abs!) + for CRISPR-mediated gene silencing. Check it out!
#epigenetics
#proteinengineering
#chemicalbiology
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Just bros helping bros: male moths use horizontal gene transfer to promote successful courtship & mating. In other words, they're true wingmen........
Now online! HGT is widespread in insects and contributes to male courtship in lepidopterans
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Receiving a hand-written letter from a grad student mentee at the end of their rotation expressing how much they appreciate you + your mentorship >> good data tbh
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preparing for a weekend in Boston the only way I know how: listening to the quintessential modern New England hardcore album on repeat
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Come join us!
Please join us on April 23rd to celebrate Earth Day with a hike in Sleeping Giant State Park! We'll have food and a raffle to celebrate!
Sign up here:
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had a great time at
#cshlmetab23
! feeling amped to get back to work and grateful for all the new connections!
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I dance with the devil almost daily (carry stacks of 10+ plates of precious cells to the microscope knowing full well I will never forgive myself if I drop them).
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me working at an Ivy League listening to Dead Prez's They School
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"Cells must put their affairs in order before they die."
Finally, the function of the mysterious capase-7 is revealed. For the record, Death Facilitator is a 10/10 death metal band name.
Nature research paper: Caspase-7 activates ASM to repair gasdermin and perforin pores
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reminder that it's acab today and every single other day, past, present, and future.
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wife put on the Rugrats 2 movie on as a joke - 5 minutes later both crying real tears. they didn't need to go this hard wtf?
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@drstarbird
@WeyemiLab_UT
LOL WHAT! Oh no... I'm actually studying ROS/cell death - lord knows how much data I've inadvertently skewed... thanks for the heads up!
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Strictly Black Dahlia Murder on rotation today.
Trevor Strnad forever 💔
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the ocean rn
The "Icon Of The Seas" sets sail in January 2024. 5610 passengers, 2350 crew members, 5 times larger and heavier than the Titanic, 19 floors with more than 40 bars, restaurants and bowling alleys. What a monstrosity!
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massive W - hoping Yale et al will follow suit!
BREAKING: After a decade of constant pressure by students, faculty, and alums,
@HARVARD
IS FINALLY DIVESTING FROM FOSSIL FUELS.
It’s a massive victory for our community, the climate movement, and the world — and a strike against the power of the fossil fuel industry. (THREAD)
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Calling all mid- to late-stage US postdocs looking to transition to a faculty position!!
Check out the post below to take part in a fantastic initiative to highlight the diverse future leaders in life sciences research. Register by Dec 1 and follow
@InterSciFellows
for updates!
The 2021
#IntersectionsScienceFellowsSymposium
will highlight research from talented mid- to late stage postdocs. Present your work, find mentors and network with scientists from diverse backgrounds! Apply here .
#BlackinSTEM
#LatinXinSTEM
#academicchatter
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@YaleBPA
@brookemariebell
Also - here's the pamphlet we made with info on the climate crisis and how it disproportionately affects communities of color. Check it out!
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a decades-long, hard-earned victory thanks to the tireless work of local 33 (+34/35) and generations of community organizers!!!
We Won! Grad workers at Yale said overwhelmingly: UNION YES!
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@pencil_gang
@DrBenNeel
@bariweiss
Better wording, in that case: the law firm produced a report which Whitehead used to determine he was guilty of violating their policies on sexual harassment.
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Recent action by
@ScientistRebel1
&
@ClimateHuman
[follow them!] reminded me that we everyday-scientists have a moral responsibility to help turn this mess around. So many get into medicine/research wanting to help others, discover a new medicine that will save lives.
(9/12)
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...and one month later.
*Nipsey Hussle's Grindin All My Life plays softly in the distance*
#10000hours
#perseverance
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Twitter really just put this post from someone I don't follow at the top of my feed just to spite me.
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@ArnaudjLegrand
since we were talking about science+metal wanted to drop this:
I played bass in a melodeath band for many years and since I was studying microbiology I of course had to write a song about the plague.
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it's that time of the year! since absolutely no one asked, here are my 10 favorite albums of 2021 in no order. hoping to lure out the intersection of
#sciencetwitter
and
#musictwitter
-- let's see your lists!
#aoty2021
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I mean, we got multiple Covid vaccines just about a year from genome sequencing!! An incredible feat in no small part due to the power of community. Labs dropped everything. Pivoted to Covid research. Shared unpublished data. Worked together.
(11/12)
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This is a climate emergency on a scale that dwarfs SARS-CoV2. Let's work together. Let's pivot. Let's rethink our future and do everything we can to save it while we still can.
(12/12)
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the most important climate movement imo let's GOOO
BROS WE MADE IT! MEGA THANKS to
@nellgallogly
for the article (our dads read it to us) and perfectly NAILING OUR MOVEMENT.
We can DECARB THIS MFER and get YOKED, and make some MONEY and crush a NATTY and get YOKED.
LFGGGGGGGGGGGGGGGGGG
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LET'S GO!!
BREAKING:
@Sen_JoeManchin
throws in the towel. Asks Schumer to remove energy permitting from the spending bill. Doesn’t have the votes
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Honorable mentions:
Orville Peck - Bronco
Quelle Chris - DEATHFAME
Nicholas Craven x Boldy James - Fair Exchange No Robbery
Earl Sweatshirt - SICK!
Kendrick Lamar - Mr. Morale & The Big Steppers
Kenny Beats - Louie
Freddie Gibbs - $oul $old $eparately
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👋 talk 👋 that 👋 TALK 👋
“It’s clear that for the future generation, we have to act now in a very fast way.”
- 2021 physics laureate Giorgio Parisi speaks about the current climate situation at this morning's
#NobelPrize
press conference.
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Tomorrow is election day: please vote if you are eligible. We need as many votes as possible. If you have time to spare, consider doing some phonebanking. Our democracy, environment, society, etc, depend on it.
Info/register here:
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for what it's worth, thanks to the tireless efforts of local activists+advocates, like my amazing wife, Killingly is currently dead in the water!
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feel like not enough people recognize Hanson's 1997 opus "Mmmbop" as a powerful, cautionary statement on time's relentless and unforgiving forward momentum.
appreciate life folks, because in an mmmbop, it's gone.
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Breaking my Twitter strike to share my 10 favorite albums of 2022. Mostly for myself, but... enjoy!
🧵
#aoty2022
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@MayorElicker
this is deplorable. You're not "helping people move out," you are dehumanizing unhoused NHvers + violating their basic rights. Invest in safe infrastructure for the unhoused first. To be fair, this would be easier if Yale paid their taxes.
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Great paper describing an energetic substrate trade-off between innate immunity & mitochondrial metabolism in Drosophila, how this affects infection outcome, and how they are influenced by life-history events - explaining inter-individual heterogeneity.
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having Covid is fine when billy woods x Preservation, Vince Staples, Yung Lean, and Father John Misty all drop on the same day to keep you going.
#blessed
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Pollinators are essential to our ecosystem and for our survival*. Their numbers are plummeting, in large part due to climate change and overuse of toxic pesticides. Check the link below to fight the latter.
It's
#NationalPollinatorWeek
. Remember the amazing contributions these little buddies make — and take action to protect them... or else.
🐝🦋☠️😉⬇️
Here's one way:
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@The_PW_Lab
Music to my ears! Congrats on the great work. Very motivating to see there is still room for low-throughput but highly thorough dissection of complex signaling events at the forefront! Now if you'll excuse me, I have to go order some GSDMD siRNA, just to see...
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Come join us help out folks in New Haven with DESK!
👇👇👇
If you're interested in helping those experiencing homelessness or poverty in the New Haven area, please sign up and join us in volunteering with DESK
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Deciding on my first post has been stressful, so here's some shameless self-promotion to get the ball rolling.
Thankful to
@JRNLclub
for the invite to discuss the blood and sweat of my PhD. Great initiative! Honored to be among so many great scientists and such high-impact work.
.
@ToddDouglasPhD
of the
@MayaSalehMcGill
lab uncovered how dynamic post-translational modifications regulate the deubiquitinase OTULIN to fine-tune cell death outcome.
@CellReports
@McGillU
@McGillMed
@MIMM_McGill
#apoptosis
#JRNLclub
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Nice work showing the importance of Langerhans cells in the development of dermatitis in cpdm mice, my first love (well...?)
Also nice to have validation of my unpublished data (see: thesis appendix) showing a microbiota-independent phenotype!
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Vince Staples - Ramona Park Broke My Heart
Stormzy - This Is What I Mean
Pusha T - It's Almost Dry
E L U C I D - I Told Bessie
JID - The Forever Story
Charli XCX - Crash
Soul Glo - Diaspora Problems
FKA Twigs - Caprisongs
Drake x 21 Savage - Her Loss
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And the flip side: "oh you done with those mito's? here, send em my way no worries I gotchu"
Legends.
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genuinely losing my mind
Israel is boosting Columbia professor and former IDF soldier Shai Davidai. Both are calling Columbia students terrorists.
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Check out this presentation by Caitlin on a really cool project I had the pleasure of collaborating on! She shows that DCs lacking DOCK8 undergo a caspase-dependent "shattering" during migration, ultimately causing a pathological Th2 skewing in the context of pulmonary infection.
Caitlin Schneider of Judith Mandl’s lab
@mcgillu
shows how migration-induced cell shattering and death due to DOCK8-deficiency causes a T helper type 2 response.
@McGillPhysioloG
@NatImmunol
#celldeath
#dock8
#Th2
#cellmigration
#JRNLclub
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Now, climate scientists across the world are - and Indigenous leaders HAVE BEEN - screaming as loudly & clearly as they can that we are hurtling towards total ecological, environmental, and consequent societal destruction and the biomedical community barely makes a peep.
(4/12)
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Beautiful.
Single mutation makes Escherichia coli an insect mutualist
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@RosasGoncalo
@ArnaudjLegrand
hopping into this thread to say Daughters are amazing. YWGWYW was incredible.
also Behemoth's Demigod came out during my formative metal years and changed me forever. one of my favorites of all time.
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🤯Transgenerational innate immune memory via gamete DNA methylation... So cool!
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5. Ka - Languish Arts
Ka has the sharpest pen in the game, argue witchya mama. It's on full display, over his tried-and-true sparse, mostly drumless beats. Some of his most potent bars.
"We was sinnin for dinner, no reservations"
Standouts: Touché, No Reservations, Full Cobra
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Well boy do I got good news for you: you CAN save lives, right now. Talk about it, share articles, buy less, drive less, go plant-based, donate, be mindful in the lab, vote, ruffle some feathers, engage in civil disobedience.
(10/12)
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first sign of frost means it's officially Mobb Deep and Agalloch season
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@caitlinisinlab
congrats!! but get ur boots off Maryse's bench.. 😤
(sorry, yes I deleted/reposted bc I couldn't bear to look at the typo)
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the fact that my cells aren't observing MLK Day today is honestly pretty disrespectful
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6. Ka - Woeful Studies
Anotha one. Same as above. Ka really, truly does not miss.
Standouts: We Not Innocent, Counted Out, The Block
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