Jason Zhenyi Hu
@JasonHu222
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PI @Shanghai Institute of Organic Chemistry, CAS; Postdoc w/ Crews lab @Yale; PhD @Colorado Boulder. Chemical Biology; PROTAC; PhosTAC
New Haven, CT
Joined September 2013
Celebrating the first anniversary of Hu ChemBio lab, and enjoy the early summer days of Shanghai!
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Super excited to see our PhosTAC work being featured by Craig and Prof. Bertozzi😀.
What an honor to host @CraigMCrews, inventor of PRO(and other)TACs, as keynote lecturer and guest at our @Stanford_ChEMH CBI graduate program retreat. Inspiring role model for translational chemical biology and entrepreneurship 🙏
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In this study, we combined the “occupancy-driven modality” of TKIs with the “event-driven modality” of bifunctional molecules to achieve dual inhibition of EGFR with TKI-based PhosTAC, which reveals differential downstream effects.
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I’m thrilled to share our recent work on dual inhition of EGFR with PhosTAC. Congrats to the team @POHANCHEN9, Wenxue, @siszheng, @JacquesSaarbach, Ines and John. And we are deeply grateful for the great mentorship from @Yanshen73854711 and @CraigMCrews!.
www.science.org
Bifunctional PhosTACs combine the strength of a phosphatase and a kinase inhibitor to achieve dual inhibition of EGFR.
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RT @J_A_C_S: Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality @CraigMCrews @Tod….
pubs.acs.org
Microtubule-associated protein tau is essential for microtubule assembly and stabilization. Hyperphosphorylation of the microtubule-associated protein tau plays an important pathological role in the...
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Excited to share our Tau PhosTAC paper on @J_A_C_S . PhosTAC provides a new modality for neurodegenerative diseases treatment. Many thanks to @CraigMCrews, and the awesome team Po-Han Chen, Wenxue Li, @ToddDouglasPhD , John @Yanshen73854711 🎉#PhosTAC.
pubs.acs.org
Microtubule-associated protein tau is essential for microtubule assembly and stabilization. Hyperphosphorylation of the microtubule-associated protein tau plays an important pathological role in the...
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RT @CraigMCrews: Ever wanted to dephosphorylate just a single phosphoprotein instead of blocking all downstream kinase substrates with a ki….
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