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Muñoz-Pinedo/Ernest Nadal - PRETT lab Profile
Muñoz-Pinedo/Ernest Nadal - PRETT lab

@apoptosislab

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Cell death, starvation, cancer metabolism, ISR, NSCLC, mesothelioma, #ApoList #MetaboList. Posts mostly by CrisMP. Oncobell, Thoracic Tumors (PReTT)@idibell_cat

Barcelona, España
Joined February 2017
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@apoptosislab
Muñoz-Pinedo/Ernest Nadal - PRETT lab
6 years
Ever wondered what happens to starved cells that don't die? Do they do anything? Check @franzi_la last paper. --Spoiler: they tell other cells that they're hungry (1/15) #Tweetorial 👇 https://t.co/2pg0kjw66s @idibell_cat @ICOnoticies @CampusBellvitge
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@apoptosislab
Muñoz-Pinedo/Ernest Nadal - PRETT lab
2 days
'Alternative' translational control by mTOR through the RNA binding protein DDX21, from Monika Wolkers' team mTOR signaling during T cell activation promotes cytokine production in T cells through 3′ UTR-mediated translation control: Molecular Cell.
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cell.com
Jurgens et al. report that mTOR employs the 3′ UTR of cytokines to regulate their production. mTOR signaling upon T cell activation results in DDX21 binding to AU-rich elements within the 3′ UTRs,...
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@MolecularCell
Molecular Cell
3 days
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis https://t.co/IiPk4jcp0J
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@apoptosislab
Muñoz-Pinedo/Ernest Nadal - PRETT lab
3 days
Good morning! (In Europe) Here's a selection of papers on cancer metabolism, cancer-inmunometabolism and cancer and diet and systemic metabolism (cachexia), as well as nutrient sensing and hypoxia. MetaboList, November 2025 https://t.co/E4s3zRkqWH
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metabolist.wordpress.com
Glucose, lactate/acidosis Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer Zhengwei Wu, Zhenxun Wang, Seow …
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@apoptosislab
Muñoz-Pinedo/Ernest Nadal - PRETT lab
4 days
Glucose and ribose in an asteroid! Bio-essential sugars in samples from asteroid Bennu - Furukawa et al | Nature Geoscience
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nature.com
Nature Geoscience - Samples returned from asteroid Bennu contain bio-essential sugars such as ribose and glucose that may have formed in the parent asteroid from brines containing formaldehyde,...
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@ICO_oncologia
Institut Català d'Oncologia
6 days
Des de l'@ICO_oncologia i @hbellvitge hem participat al reportatge “Càncer, investigar dóna vida” de @som3cat i #30minuts, un repàs intens i esperançador de com han evolucionat els tractaments i la supervivència del #càncer en les darreres 3 dècades 👇 https://t.co/iJI9UtLQhp
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@apoptosislab
Muñoz-Pinedo/Ernest Nadal - PRETT lab
8 days
That’s cool @RutterLab
@eLife
eLife - the journal
9 days
This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins. https://t.co/X1n0OEsCeK
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@RemailehAbu
Muhannad Abu-Remaileh
3 months
Excited to share our new preprint—the main project of my postdoc in the Kaelin lab! Blocking HIF2 doesn’t just slow tumors—it can reverse cachexia and hypercalcemia in kidney cancer. In the OSRC-2 model, HIF2 inhibition restored weight, preserved fat/muscle, and rescued survival.
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@LabWaggoner
Waggoner Lab
8 days
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@apoptosislab
Muñoz-Pinedo/Ernest Nadal - PRETT lab
9 days
This has to stop
@Lo_Zanzi
Ivan Zanoni
9 days
#NoTimeToDie! Welcome mitoxyperiosis! ⁦@ThiruKanneganti Wang⁩ &co show ⁦@CellCellPress⁩ that carbon starvation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria driven membrane oxidative damage
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@apoptosislab
Muñoz-Pinedo/Ernest Nadal - PRETT lab
10 days
Ferroptosis induced by inhibition of GPX4 suppressed tumor growth in 2D, but not in 3D or in vivo. Lipids are different "Lipid Composition Alters Ferroptosis Sensitivity"
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aacrjournals.org
Changes in lipid composition can affect induction of ferroptosis, explaining why sensitivity of cancer cells in tissue culture does not reliably translate to more complex models and suggesting...
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@idibell_cat
IDIBELL
13 days
Rejuvenating the blood: a new pharmacological intervention targeting RhoA in hematopoietic stem cells🩸 According to a study published in @NatureAging, treating these cells with the drug Rhosin rejuvenates them and helps produce healthier blood cells💪 👉 https://t.co/QOfnkoLblK
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@apoptosislab
Muñoz-Pinedo/Ernest Nadal - PRETT lab
16 days
Unintended consequence of posting preprints: spammer journal emails asking to publish *it*. 20 daily scientific spam emails instead of 10
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@apoptosislab
Muñoz-Pinedo/Ernest Nadal - PRETT lab
18 days
Know this”, he says. “The main function of reviewers and the editorial process is to take your lovely, wonderful paper That you love so much, that you adore And convert it, step by step, into that which you will call ‘That frogging’ paper Mole @J_Cell_Sci https://t.co/OLAelKMkFV
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journals.biologists.com
Mole has finished his sojourn through Grant Hell (seeMole's Comedia I and Mole's Comedia II), accompanied by the shade of Sir Francis Bacon as his guide. Shaken (but not stirred), he begins to write...
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@MarcusDGon
Marcus Goncalves
19 days
Join us in San Francisco for an evidence based, clinically focused dinner session on cancer cachexia at #ASCOGI. Secure your spot for this workshop that brings together leaders in GI oncology and metabolism:
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@NatMetabolism
Nature Metabolism
22 days
RESEARCH | @xiaobowang, I Tabas et al (Columbia U, USA) #Hepatocyte Caspase-8 in #MASH promotes the activation of hepatic stellate cells and liver fibrosis through an #apoptosis-independent mechanism 🐭 https://t.co/4FFbR1ThpX
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nature.com
Nature Metabolism - Hepatocyte caspase-8 in MASH promotes the activation of hepatic stellate cells and liver fibrosis through an apoptosis-independent mechanism
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@apoptosislab
Muñoz-Pinedo/Ernest Nadal - PRETT lab
24 days
More interesting research from our Institute. Oncology Bellvitge rocks
@idibell_cat
IDIBELL
24 days
An IDIBELL-ICO team paves the way to study the impact of polyphenols, components of plant-based diets, on the risk of developing a type of blood cancer🥬 They have laid the first stone on the path of this research, being a pioneering study in Europe📍 👉 https://t.co/qxr6H0EFya
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@MarcusDGon
Marcus Goncalves
24 days
Interested in doing clinical science in the best city in the world? Clinician-Investigator job with NYU Grossman School of Medicine
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nejmcareercenter.org
The Holman Division of Endocrinology, Diabetes & Metabolism at NYU Langone Health is seeking an academically oriented physician
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@apoptosislab
Muñoz-Pinedo/Ernest Nadal - PRETT lab
24 days
I strongly recommend this group, who are our neighbors. You would learn a lot, publish well and have fun. We are also looking for an applicant, by the way :-)
@BRivera_Polo
Barbara Rivera
24 days
Looking for a Postdoctoral fellowship? Interested in hereditary cancer and paediatric cancer genomics and models? The Rare TumorS Lab is looking for candidates to apply to the JdC call. Hurry up, the deadline is approaching! DM_me!
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@apoptosislab
Muñoz-Pinedo/Ernest Nadal - PRETT lab
26 days
Another favorite from last month, also from a European group: "Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation" https://t.co/bLiuagMUhj @VagnerCurie
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journals.plos.org
Hexokinase 2 (HK2) is traditionally known for its metabolic role in glycolysis. This study shows that it also functions as an RNA-binding protein that regulates mRNA translation, particularly of...
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