Muñoz-Pinedo/Ernest Nadal - PRETT lab
@apoptosislab
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Cell death, starvation, cancer metabolism, ISR, NSCLC, mesothelioma, #ApoList #MetaboList. Posts mostly by CrisMP. Oncobell, Thoracic Tumors (PReTT)@idibell_cat
Barcelona, España
Joined February 2017
Ever wondered what happens to starved cells that don't die? Do they do anything? Check @franzi_la last paper. --Spoiler: they tell other cells that they're hungry (1/15) #Tweetorial 👇 https://t.co/2pg0kjw66s
@idibell_cat @ICOnoticies @CampusBellvitge
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'Alternative' translational control by mTOR through the RNA binding protein DDX21, from Monika Wolkers' team mTOR signaling during T cell activation promotes cytokine production in T cells through 3′ UTR-mediated translation control: Molecular Cell.
cell.com
Jurgens et al. report that mTOR employs the 3′ UTR of cytokines to regulate their production. mTOR signaling upon T cell activation results in DDX21 binding to AU-rich elements within the 3′ UTRs,...
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Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis https://t.co/IiPk4jcp0J
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Good morning! (In Europe) Here's a selection of papers on cancer metabolism, cancer-inmunometabolism and cancer and diet and systemic metabolism (cachexia), as well as nutrient sensing and hypoxia. MetaboList, November 2025 https://t.co/E4s3zRkqWH
metabolist.wordpress.com
Glucose, lactate/acidosis Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer Zhengwei Wu, Zhenxun Wang, Seow …
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Glucose and ribose in an asteroid! Bio-essential sugars in samples from asteroid Bennu - Furukawa et al | Nature Geoscience
nature.com
Nature Geoscience - Samples returned from asteroid Bennu contain bio-essential sugars such as ribose and glucose that may have formed in the parent asteroid from brines containing formaldehyde,...
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Des de l'@ICO_oncologia i @hbellvitge hem participat al reportatge “Càncer, investigar dóna vida” de @som3cat i #30minuts, un repàs intens i esperançador de com han evolucionat els tractaments i la supervivència del #càncer en les darreres 3 dècades 👇 https://t.co/iJI9UtLQhp
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Nice comment by Angela Montero and Lydia Finley @lydfinley
https://t.co/qGtsnfx0BE
elifesciences.org
The metabolic fate of a nutrient called pyruvate determines how big cells become.
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That’s cool @RutterLab
This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins. https://t.co/X1n0OEsCeK
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Excited to share our new preprint—the main project of my postdoc in the Kaelin lab! Blocking HIF2 doesn’t just slow tumors—it can reverse cachexia and hypercalcemia in kidney cancer. In the OSRC-2 model, HIF2 inhibition restored weight, preserved fat/muscle, and rescued survival.
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Targeting of HIF2-driven cachexia in kidney cancer @NatureMedicine @RemailehAbu @kaelin_lab
@DanaFarber @harvardmed
https://t.co/HuXjqnUvdl
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This has to stop
#NoTimeToDie! Welcome mitoxyperiosis! @ThiruKanneganti Wang &co show @CellCellPress that carbon starvation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria driven membrane oxidative damage
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Ferroptosis induced by inhibition of GPX4 suppressed tumor growth in 2D, but not in 3D or in vivo. Lipids are different "Lipid Composition Alters Ferroptosis Sensitivity"
aacrjournals.org
Changes in lipid composition can affect induction of ferroptosis, explaining why sensitivity of cancer cells in tissue culture does not reliably translate to more complex models and suggesting...
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Rejuvenating the blood: a new pharmacological intervention targeting RhoA in hematopoietic stem cells🩸 According to a study published in @NatureAging, treating these cells with the drug Rhosin rejuvenates them and helps produce healthier blood cells💪 👉 https://t.co/QOfnkoLblK
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Unintended consequence of posting preprints: spammer journal emails asking to publish *it*. 20 daily scientific spam emails instead of 10
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Know this”, he says. “The main function of reviewers and the editorial process is to take your lovely, wonderful paper That you love so much, that you adore And convert it, step by step, into that which you will call ‘That frogging’ paper Mole @J_Cell_Sci
https://t.co/OLAelKMkFV
journals.biologists.com
Mole has finished his sojourn through Grant Hell (seeMole's Comedia I and Mole's Comedia II), accompanied by the shade of Sir Francis Bacon as his guide. Shaken (but not stirred), he begins to write...
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Join us in San Francisco for an evidence based, clinically focused dinner session on cancer cachexia at #ASCOGI. Secure your spot for this workshop that brings together leaders in GI oncology and metabolism:
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RESEARCH | @xiaobowang, I Tabas et al (Columbia U, USA) #Hepatocyte Caspase-8 in #MASH promotes the activation of hepatic stellate cells and liver fibrosis through an #apoptosis-independent mechanism 🐭 https://t.co/4FFbR1ThpX
nature.com
Nature Metabolism - Hepatocyte caspase-8 in MASH promotes the activation of hepatic stellate cells and liver fibrosis through an apoptosis-independent mechanism
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More interesting research from our Institute. Oncology Bellvitge rocks
An IDIBELL-ICO team paves the way to study the impact of polyphenols, components of plant-based diets, on the risk of developing a type of blood cancer🥬 They have laid the first stone on the path of this research, being a pioneering study in Europe📍 👉 https://t.co/qxr6H0EFya
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Interested in doing clinical science in the best city in the world? Clinician-Investigator job with NYU Grossman School of Medicine
nejmcareercenter.org
The Holman Division of Endocrinology, Diabetes & Metabolism at NYU Langone Health is seeking an academically oriented physician
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I strongly recommend this group, who are our neighbors. You would learn a lot, publish well and have fun. We are also looking for an applicant, by the way :-)
Looking for a Postdoctoral fellowship? Interested in hereditary cancer and paediatric cancer genomics and models? The Rare TumorS Lab is looking for candidates to apply to the JdC call. Hurry up, the deadline is approaching! DM_me!
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Another favorite from last month, also from a European group: "Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation" https://t.co/bLiuagMUhj
@VagnerCurie
journals.plos.org
Hexokinase 2 (HK2) is traditionally known for its metabolic role in glycolysis. This study shows that it also functions as an RNA-binding protein that regulates mRNA translation, particularly of...
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