Thejus Jayakrishnan
@ThejusJay
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Gastrointestinal Oncologist at @DanaFarber @Harvardmed via @ClevelandClinic @CCFhemonc @AHNIMres & @aiims_newdelhi #earlyonsetcancers #multiomics 📚🚴
Boston, MA
Joined September 2019
I am riding 85 miles @PanMass to raise funds for @DFarberYoungCRC Please support if you can! https://t.co/D29C1Qg46R
profile.pmc.org
PMC Profiles
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Safety of ICI Rechallenge Following irAEs Recurrence rate for the same irAE ✅Pneumonitis: 20-31% ✅Hepatitis: 22-35% ✅Colitis: 34-39% 👉ASCO, ESMO, and NCCN guidelines are summarized in the following review article in JJCO. https://t.co/FJPfKjwS0R
@OncoAlert
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Proud mentee moments Learning the art of grant writing with Dr Khorana @aakonc has been such a privilege. The thought process, discipline, and vision behind every line remind me why mentorship matters. #MedTwitter #Oncology #asco
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Important paper. The dogma/SOC is locally recurrent or persistent anal SCC requires APR, but some pts decline surgery or tumors inoperable. In this series, 39Gy in 1.5Gy BID lead to CR in 46%, suggesting many tumors still radiosensitive & reRT can achieve durable LC. @OncoAlert
Ever thought about 🔄️re-irradiation for squamous cell carcinoma of the anal canal? Turns out... it can be done! Thanks to this ⏪retrospective study of 35 patients by @jordan_McD3 @ThatDamDoc @PrajnanDasMD @eugenekoay @ebludmir @Snoticewala @VanMorrisMD @DrEmmaHolliday
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Today is World #PancreaticCancer Day and at @DanaFarber, we are lighting our Healing Garden purple tonight to raise awareness. Read more here about three ways research could improve pancreatic cancer treatment: https://t.co/zsDTPUzA7J
@DanaFarber_Hale
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Very excited to see this in print. Our latest commentary highlighting the "missing piece of the puzzle" in neuroendocrine neoplasm classification, published in Med @CellPressNews . NENs are classified based on morphology, site of origin, and Ki-67 proliferation indices. These
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Kicking off the first annual Young Adult Cancer Symposium! Excited to be here among like-minded patients, survivors, caregivers, advocates and healthcare professionals dedicated to take action to figure out why young adults are getting cancer at an alarming rate! #AYACSM
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On @NPR @MorningEdition, @DanaFarber’s Dr. Ben Schlechter (@ben_schlechter) underscores the role of healthy eating in colorectal cancer prevention as new research associates ultra-processed foods to higher risk. https://t.co/qtdNG3SVHC CC: @DFarberYoungCRC
npr.org
A new study found that women who eat a lot of ultra-processed foods were 1.5 times more likely to develop pre-cancerous polyps before the age of 50, compared to those with healthier diets.
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@allisonoconn @JamesClearyMD A pancreatic cancer precursor lesion (Pancreatic intraepithelial neoplasia or PanIN) with complete loss of MTAP expression secondary to a p16 homozygous deletion. The normal ductal epithelium retains expression.
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Recurrence Patterns of Esophageal Adenocarcinoma in the ESOPEC Trial Comparing Perioperative CTx With Preoperative Chemoradiotherapy @JCO_ASCO
https://t.co/FN6K1rdWeV 👉similar locoregional recurrence 👉less Distant recurrence with FLOT 🧐FLOT improved OS through better systemic
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Unlike the G12Cmutation, which has a cysteine residue that can be targeted by covalent inhibitors, G12R lacks this specific residue, requiring different approaches. Very interesting idea for KRAS G12 R mutations @Dr_R_Kurzrock cc’ @Aiims1742 @DavidHongMD
Just out. 🎯🔥🎯Pancreatic cancers with KRA G12R can respond to MeK inhibitors: dissecting the mechanisms. https://t.co/oKgebxfYDk
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Another @VanAllenLab @DanaFarber_GU collaboration with our friend @BraunMDPhD + many super stars like @Chrislabaki1 @eddy_saad @ZiadBakouny et al (all co-mentored @VanAllenLab)--we will unlock biomarkers of IO resistance in RCC, 1 step at a time. cc: @DanaFarber_GU @ImmunityCP
Here's our latest - a deep dive into myeloid mediated immunotherapy resistance in kidney cancer, pairing single cell meta-analysis with companion experiments (h/t @DrChoueiri + @BraunMDPhD collaborations) Congrats Kevin Bi et al! @DanaFarber @broadinstitute @ImmunityCP
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👇🏽This is an excellent read 📕 📖 🔖 if you get a chance @JCO_ASCO
#TumorBoardTuesday
@TumorBoardTues @pashtoonkasi @IntegrityCE @JulianaRBeal @PestanaRC @camilagismondi_ @CathyEngMD @GIMedOnc @dr_yakupergun @EvelynWongYT @Erman_Akkus @GIcancerDoc @MyriamChalabi @ChiaraCrem1 @TaberneroJosep @ClaraMontagut @pau_mascaro 👨🏽🏫Mini Tweetorial 9👨🏽🏫 🔥 JCO 2025 (Beiter et al.): IO in pMMR CRC — striking gap in ORR4⃣NLMCRC vs CRLM 👉 ORR often 20–30% in NLCRC vs ~0–10% in CRLM Are we underestimating a true biology-driven subgroup❓ 📊 https://t.co/3mSInk53dS
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🔥off the press🔥 LEAP-012 phase 3 study: TACE with lenvatinib + pembrolizumab vs plc for intermediate stage HCC 👉IA just released 👉PFS benefit maintained 👉No OS benefit, study stopped 🧐How to implement in clinical practice? I still consider as an effective option for
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👀this🧐thoughtful piece by Dr. @gagan_brar24 on utility of #ctDNA🩸🧬 in non-metastatic rectal #cancer. As we talk about organ sparing approaches, a number of scenarios to keep in mind👇🏽. 💡ctDNA “origin”💦 would be of value in these circumstances. @OncoAlert @OncJournal📚🗞️
Reviewing the utility of ctDNA in rectal cancer with @pashtoonkasi published today @OncJournal
https://t.co/GeL6DV7y2n
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Happy to share that the data we presented at #ASCO2025 @ASCO (and many more details) are now published in @JCOPO_ASCO : Whole-body MRI (WBMRI) among individuals with Li-Fraumeni Syndrome (LFS) @DanaFarberNews @DFCIPopSci
https://t.co/tQvrU7XaFr
ascopubs.org
PURPOSEIndividuals with Li-Fraumeni syndrome (LFS) are at risk of developing cancer in multiple organs and therefore require a multimodal screening program. We assessed the performance of annual...
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Last week's Colorectal Club was led by @ben_schlechter, who gave a fascinating talk about new immunotherapy approaches in #colorectalcancer. Works well for certain subsets of patients but comes with its own caveats @DanaFarber @KimmieNgMD
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This month's Colorectal Club was honored to have Dr. Ramesh Shivdasani share some of his work on intestinal stem cell dynamics in adenoma formation. Very intriguing findings! @DanaFarber
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cT3/T4 per CT identifies patients with dMMR colon cancer with substantial risk of recurrence despite FOLFOX: cT3N0: 84% 3-year DFS cT4N0: 70% 3-year DFS Of course, NICHE2 : 100% 3-year DFS for cT3/4 For patients with dMMR colon cancer cT3/T4 by CT: we should discuss risks and
Proud to present combined NICHE-2 & FOXTROT analysis in dMMR locally advanced CC -Neoadjuvant IO superior to chemo -20% relapses with chemo in "good prognosis" group; 30% if T4 -Minimal path response to chemo - Clinical staging identified high risk group
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Team Beyond CRC at this year's Jimmy Fund Walk! We are so grateful to have such an amazing team walking and fundraising for the Jimmy Fund and the Young-Onset Colorectal Cancer Center. @TheJimmyFund @DanaFarber @KimmieNgMD
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