JCO Precision Oncology
@JCOPO_ASCO
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Original research, reports, opinions, and reviews advancing the science and practice of #precisiononcology. Part of @JCO_ASCO family of journals.
Joined July 2016
RT @tuttsakhil: Implementation of DPYD and UGT1A1 Testing in Patients With GI Cancer: A Prospective, Nonrandomized Clinical Trial |@JCOPO_A….
ascopubs.org
PURPOSETo determine the feasibility and effectiveness of implementing pretreatment DPYD/UGT1A1 testing in patients with gastrointestinal cancer and its impact compared with a biobank population.MAT...
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Enhanced Detection of Druggable Mutations in Non–Small.Cell Lung Cancer Using Targeted Collection of Bronchial.Washing Fluid Compared With Plasma and Tumor Tissue. Read the full article: #NSCLC #LungCancer.
ascopubs.org
PURPOSENext-generation sequencing (NGS) has become the gold standard for the molecular testing of patients with non–small cell lung cancer (NSCLC). This prospective study evaluated the performance of...
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RT @tuttsakhil: Multi-Regional Profiling of Epidermal Growth Factor Receptor L858R Mutation-Positive Metastatic Renal Pelvic Cancer Success….
ascopubs.org
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Prognostic Indicators of Preoperative Fluorouracil, Leucovorin, Oxaliplatin, and Docetaxel Efficacy in Locally Advanced Gastroesophageal and Gastric Cancer: Integrating Biomarker Analysis and Clinicopathological Factors. Read the full article.
ascopubs.org
PURPOSEPerioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) is a standard treatment for locally advanced gastric/gastroesophageal junction cancer (GC/GEJC). The impact of...
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Mucin 16–Directed Therapy in #PediatricSarcomas: Case.Evidence of Ubamatamab Efficacy in Epithelioid Sarcoma and Its Implications for Other Sarcoma Subtypes. Read the full article: .#pedonc.
ascopubs.org
PURPOSEEpithelioid sarcoma (ES) and malignant rhabdoid tumor (MRT) are rare soft tissue sarcomas with poor prognoses. Although mucin 16 (MUC16) and its soluble form, cancer antigen 125 (CA125), are...
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RT @tuttsakhil: Mucin 16–Directed Therapy in Pediatric Sarcomas: Case Evidence of Ubamatamab Efficacy in Epithelioid Sarcoma and Its Implic….
ascopubs.org
PURPOSEEpithelioid sarcoma (ES) and malignant rhabdoid tumor (MRT) are rare soft tissue sarcomas with poor prognoses. Although mucin 16 (MUC16) and its soluble form, cancer antigen 125 (CA125), are...
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RT @KoheiShitara: Please to share biomarker analysis of FLOT-treated gastric/GEJ cancer @JCOPO_ASCO @ASCO : CLDN18.2 expression declined af….
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Personalized N-of-1 Combination Therapies for Advanced Gastrointestinal Stromal Tumors: #gicsm. Authored by @JasonSicklick, @Dr_R_Kurzrock, et al.
ascopubs.org
PURPOSEGastrointestinal stromal tumor (GIST) resistance to imatinib and other tyrosine kinase inhibitors poses an ongoing clinical challenge. We investigated molecularly matched combination therapies...
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Genomic Landscape and Clinical Relevance in Chinese.Patients With Upper Tract Urothelial Carcinoma. Read the full article.
ascopubs.org
PURPOSEUpper tract urothelial carcinoma (UTUC) is one of the common urothelial cancers. Although large cohorts have illustrated spectrum of germline mutations, landscape of somatic alterations has...
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Physiologically Based Pharmacokinetic Model to Assess the Drug-Drug-Gene Interaction Potential of Belzutifan in.Combination With Cyclin-Dependent Kinase 4/6 Inhibitors. Read the full article.
ascopubs.org
PURPOSEBelzutifan is a novel treatment for von Hippel-Lindau–associated cancers and is being evaluated in clinical trials for the treatment of renal cell carcinoma in combination with the cyclin-de...
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CNS Involvement by North American North American-Adult T-cell Leukemia/Lymphoma Is Associated With Discrete Dissemination Patterns and Molecular Profiles, Involving XPO1 E571 and KLF2/PI3KCD in Selected Cases. Read the full article.
ascopubs.org
PURPOSECNS involvement in North American adult T-cell leukemia/lymphoma (NA-ATLL) remains poorly understood. This study examined the CNS involvement in patients with ATLL treated at a tertiary...
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Prospective Clinical Validation of a Combinatorial Functional Precision Medicine Platform in Relapsed/Refractory Non-Hodgkin's Lymphoma. Read full article.
ascopubs.org
PURPOSEDespite initially responding to first-line treatment, many patients with non-Hodgkin's lymphoma (NHL) eventually relapse or are refractory. These patients are empirically subjected to salvage...
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Deep-Learning Model for Real-Time Prediction of Recurrence in Early-Stage Non–Small Cell Lung Cancer: A Multimodal Approach (RADAR CARE Study). Co-authored by @HyunAeJung62662. Read full article.
ascopubs.org
PURPOSEThe surveillance protocol for early-stage non–small cell lung cancer (NSCLC) is not contingent upon individualized risk factors for recurrence. This study aimed to use comprehensive data from...
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RT @tuttsakhil: Case of KRAS G12C-Mutated AML Treated With Sotorasib | @JCOPO_ASCO
ascopubs.org
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.@HyunAeJung62662 et al's pilot study introduces a deep-learning model that uses multimodal data from routine clinical practice to predict relapses in early-stage #NSCLC. Read the full article. .#LCSM
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RT @tuttsakhil: Combination Therapy With Olaparib Plus Lenvatinib in a Patient With BRCA2-Mutated, Radioiodine-Refractory, Metastatic Papil….
ascopubs.org
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RT @tuttsakhil: Response-Adapted Surgical and Radiotherapy De-Escalation in Resectable Cutaneous Squamous Cell Cancer Using Pembrolizumab:….
ascopubs.org
PURPOSEThe high rates of pathologic complete response (pCR) after neoadjuvant immunotherapy have generated interest for a risk adaptive surgical and radiotherapy-free management approach to reduce...
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Cancer Testis Antigen Expression Correlates With Immune.Activation and Survival in Small Bowel Neuroendocrine Tumors. Read the full article.
ascopubs.org
PURPOSESmall bowel neuroendocrine tumors (SBNET) frequently present with metastatic disease, and the efficacy of available systemic therapies, especially immune checkpoint blockade, is limited....
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Prognostic Role of MTAP Loss in Cholangiocarcinoma: Authored by @alm_o et al.
ascopubs.org
PURPOSEMethylthioadenosine phosphorylase (MTAP) loss is a common genomic event in cancer and is associated with an immunologically cold phenotype. Recent research has highlighted a synthetic lethal...
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