Roberto Pestana, MD, PhD
@PestanaRC
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I treat patients with sarcoma and gastrointestinal malignancies at Hospital Israelita Albert Einstein and serve as chair of the LACOG sarcoma group
São Paulo, Brasil
Joined April 2018
I am proud to share my latest article, published @CAonline (an unbelievable impact factor of 508 🤯) We review the tissue-agnostic potential of antibody-drug conjugates The most amazing part is it all started w/ Twitter interactions w/ @PTarantinoMD
https://t.co/B9IIJalvRT
acsjournals.onlinelibrary.wiley.com
As distinct cancer biomarkers have been discovered in recent years, a need to reclassify tumors by more than their histology has been proposed, and therapies are now tailored to treat cancers based...
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#CTOS2025 - a pleasure to moderate the session on Sarcoma & Society: Equity, Quality of Life & Global Care alongside the great Dr. Catherine Sarre and Prof. Winette van de Graaf @sarresurgeon @ctosociety @Winette_vdGraaf
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Historical - a great win for patients w/ chondrosarcoma! #CTOS2025 @RobinL_Jones
🚨Historical presentation at #CTOS2025 ChonDRAgon - first positive randomised trial in chondrosarcoma 🔹Ozekibart vs placebo 🔹 mPFS 5.52 vs 2.66 months 🔹 HR 0.479; p<0.0001 🔹 a manageable safety profile - most common TRAE: fatigue, diarrhea, and nausea
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#CTOS2025 - Ozekibart shows impressive benefit in PFS in patients w/ advanced conventional chondrosarcoma. The first randomizes trial w/ benefit of a systemic therapy in this disease @ctosociety @RobinL_Jones
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#CTOS2025 - nice to see a presentation highlighting the potential of insights from early-phase trials to treat rare cancers Check our prior publications: https://t.co/TyFgFMPzXc
https://t.co/yEleKeKwBG
aacrjournals.org
AbstractPurpose:. Recently, the Connective Tissue Oncology Society published consensus guidelines for recognizing ultrarare sarcomas (URS), defined as sarcomas with an incidence ≤1 per 1,000,000. We...
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#CTOS2025 - chondrosarcoma remains hard to treat even in the era of novel agents in the largest phase I unit in the world @MDAndersonNews @ctosociety
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#CTOS2025 pathologic fracture associated w/ worse distance metastasis ans disease-specific survival in high-grade chondrosarcoma @ctosociety A product of the biology of these tumors?
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#CTOS2025 Following the productive pre-congress meeting on genetic predisposition in sarcoma, a presentation on cancer surveillance for patients with genetic predisposition
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Whole lung irradiation (w/ boost when appripriate) shows promising results in adults with Ewing Sarcoma. Unfortunately, still very short PFS for CIC-DUX sarcoma #CTOS2025 @ctosociety
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Larotrectinib results in durable responses In patients w/ NTRK fusion-positive swrcomas -12% of patients with responses ongoing after 5 years #CTOS2025 @ctosociety
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Molecular profiling is a TOOL for sarcoma diagnosis, morphology is still key. As Prof. Dei Tos states: a fool with a tool is still a fool #CTOS2025 @ctosociety
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Herman Suit Lecture by Dr Paolo Dei Tos taking us through the journey of pathologic reclassification of sarcomas: A marriage between pathology and genetics #CTOS2025 #CTOS @ctosociety
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Inspiring opening session at #CTOS2025…reminding the past and preparing for a bright future. Especially nice to see GLOBAL collaboration as a goal @ctosociety @SilviaStacchia @alegronchi @DCalleMD @DrCeSarcoma @herbloong #CTOS
@SilviaStacchia opening the #CTOS2025 and highlighting the main goals of the Society: 🌟global collaboration 🌟friendship
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#CTOS 2025 started paying respects to the great Dr. Brian Van Tine, who unfortunately left us way too early. Dr. Van Tine was always incredibly kind to me and all in my team and helped my career in many ways
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Very honored to be part of this #consensus meeting on germline predispositions in sarcoma! Productive discussions on a very important topic
First activity of #CTOS2025 in full swing! The in person #consensus meeting focusing on #genetic #predispositions in #sarcomas. Multinational and multi stakeholder involvement. Thanks @SilviaStacchia @kjetilboye @DrLizConnolly @sarcomapatients and others for leading this charge.
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@TumorBoardTues @pashtoonkasi @IntegrityCE @JulianaRBeal @PestanaRC @camilagismondi_ @CathyEngMD @GIMedOnc @dr_yakupergun @EvelynWongYT @Erman_Akkus @GIcancerDoc @MyriamChalabi @ChiaraCrem1 @TaberneroJosep @ClaraMontagut 🏫 Mini Tweetorial 4 🏫 🔄 Anti-EGFR Rechallenge — WHO? 💧 ctDNA reveals who truly benefits: • Unmasks RAS/BRAF/EGFR-ECD resistance → CITRIC/PARERE: ~⅓ pts excluded by liquid biopsy • @pau_mascaro (ESMO25): low-freq clones don’t blunt ORR/DCR but link to shorter PFS/OS
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Interesting #TumorBoardTuesday case discussion on third-line therapy for metastatic pMMR colon cancer. A tough space in which there are many options but still a highly unmet medical need for novel therapies w/ higher and more durable responses.
@TumorBoardTues @pashtoonkasi @IntegrityCE @JulianaRBeal @PestanaRC @camilagismondi_ @CathyEngMD @GIMedOnc @dr_yakupergun @EvelynWongYT @Erman_Akkus @GIcancerDoc @MyriamChalabi @ChiaraCrem1 @TaberneroJosep @ClaraMontagut #TumorBoardTuesday 📋 Case: 👩⚕️ 59-year-old woman, ECOG 1 🦠 Primary: sigmoid adenocarcinoma 🧬 Molecular: RAS/RAF WT, HER2-negative, MSS 🌬️ Metastatic pattern: lung + peritoneum
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#tumorboardtuesday ✅Txs4⃣#mCRC have improved significantly - but still many Pts will need additional therapies 📢Join us Tuesday, 10-28-25 at 8PM ET as @pashtoonkasi & @mariaf_teix🗣️3rd-Line Decision-Making in Non-Driver mCRC RT and bring others into the discussion‼️
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