Vivek Subbiah, MD
@VivekSubbiah
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Chief, Early-Phase Drug Development|@SarahCannonDocs #Oncologist, #Phase1trials, #PrecisionMedicine. Tweets=My own.
Nashville, TN, USA
Joined March 2015
Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology | Nature Cancer
nature.com
Nature Cancer - Ferber et al. present an autonomous artificial intelligence agent system for deployment of specialized medical oncology computational tools, validating their system across various...
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Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response | Nature Cancer
nature.com
Nature Cancer - Han et al. report the design and characterization of a pressure-fused biomineral tablet for the long-acting sustained release of IL-2, promoting antitumor immune responses in...
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Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth | Nature Cancer
nature.com
Nature Cancer - Li and colleagues report that a septo-enteric polysynaptic circuit that is activated by chronic stress links the brain to the tumor microenvironment to promote colorectal cancer...
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Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors | Nature
nature.com
Nature - Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.
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RT @tmprowell: ‼️ Interested in use of registries for #oncology #DrugDevelopment & #regulatory decision-making? Or in pediatric #braintumor….
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Bitcoin’s on fire at $112K! Time to flip the charts on BTCC!.Exploring Cryptocurrency with Jaren Jackson Jr.🏀.
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Phase 3 Trial of Inhaled Molgramostim in Autoimmune Pulmonary Alveolar Proteinosis | New England Journal of Medicine
nejm.org
Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease characterized by progressive surfactant accumulation and hypoxemia caused by autoantibodies against granulocyte–macrophage colony-...
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Unexpected ability of large language models: predicting aging status | Nature Medicine
nature.com
Nature Medicine - We developed a large language model-based framework to predict the magnitude of aging across diverse populations using unstructured and heterogeneous data. The predicted aging was...
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Targeted Therapy of CAR+ T-Cell Lymphoma after Anti-BCMA CAR T-Cell Therapy | New England Journal of Medicine
nejm.org
A rare T-cell lymphoma after chimeric antigen receptor (CAR) T-cell therapy for myeloma was linked to CCR4 overexpression and vector integration, which highlights the need for monitoring after CAR ...
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RT @OncoDailyGI: Health-Related Quality of Life in KRASG12C-Mutated Colorectal Cancer - @VivekSubbiah . #Colorecta….
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RT @chadinabhan: The "CHALLENGE" trial on adjuvant "structured exercise" in colon cancer explained by the PI himself, Dr. Chris Booth on #H….
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Clinical utility of targeted RNA sequencing in cancer molecular diagnostics | Nature Medicine
nature.com
Nature Medicine - In a prospective study including 2,300 pediatric and adult patients with liquid and solid tumors, RNA sequencing provided actionable molecular information in 87% of cases, with...
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First-line sacituzumab tirumotecan with tagitanlimab in advanced non-small-cell lung cancer: a phase 2 trial | Nature Medicine
nature.com
Nature Medicine - In the multicenter phase 2 OptiTROP-Lung01 trial in patients with treatment-naive advanced non-small-cell lung cancers, the antibody–drug conjugate sacituzumab tirumotecan...
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Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial | Nature Medicine
nature.com
Nature Medicine - This pilot trial showed that perioperative treatment with the isocitrate dehydrogenase (IDH) inhibitor safusidenib of patients with low-grade IDH-mutant glioma, with craniotomy...
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Arsenic Trioxide and All-Trans Retinoic Acid Combination Therapy for the Treatment of High-Risk Acute Promyelocytic Leukemia: Results From the APOLLO Trial | Journal of Clinical Oncology
ascopubs.org
PURPOSEThe phase III APOLLO trial prospectively compared the efficacy of arsenic trioxide (ATO) in combination with all-trans retinoic acid (ATRA) regimen (ATRA and ATO [ATRA-ATO]) plus low-dose...
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Health-related quality of life in patients with KRASG12C-mutated chemorefractory metastatic colorectal cancer treated with sotorasib plus panitumumab or standard of care (CodeBreaK 300): results from a phase 3, randomised clinical trial - The Lancet Oncology.
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Elinzanetant for Vasomotor Symptoms from Endocrine Therapy for Breast Cancer @NEJM
nejm.org
Women receiving endocrine therapy for hormone receptor (HR)–positive breast cancer or its prevention among those at high risk for breast cancer commonly have vasomotor symptoms. Data are lacking on...
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A Breakthrough From China in a Rare Form of Kidney Cancer
jamanetwork.com
The study published in JAMA Oncology by Zhang et al1 describes the first, to our knowledge, prospective clinical trial dedicated to patients with documented fumarate hydratase–deficient renal cell...
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Personalized Primary and Secondary Prevention in Ovarian Cancer
jamanetwork.com
This Viewpoint describes available and emerging approaches for prevention and detection of ovarian cancer.
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🚨GLP-1 Receptor Agonists and Cancer Risk in Adults With Obesity @JAMAOnc
jamanetwork.com
This retrospective cohort study examines whether taking glucagon-like peptide-1 receptor agonists is associated with increased risk of different cancers among patients with obesity.
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🧬 End of an era in Houston: Honoring my brilliant friend & colleague Dr. Anirban Maitra @Aiims1742 as he wraps up an extraordinary decade at MD Anderson. A towering figure in pancreatic #CancerResearch. NYC & @nyulangone gain a visionary as Director of GI Cancer Center. Onward,.
Bittersweet day: said farewell to @Aiims1742 as he departs @MDAndersonNews for NYU (wonderful speech/symposium), & me announced as Scientific Director of the Ahmed Center for Pancreatic Cancer Research (!!). @Aiims1742–thanks for an amazing 12 yrs and prepping me for this role 🙏
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Always curious and full of energy, Beagles turn every walk into an adventure 🐾🎉.
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