Jun Qi Lab
@JunQiLab
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Chemical Biology lab @HarvardMed and @DanaFarber. We use a multidisciplinary approach to study biological roles of epigenetic proteins & transcription factors.
Boston, MA
Joined December 2018
It is so exciting to see our collaborative work with @Nilay_Sethi is now available online. My team and I are always eager to learn more about novel therapy development for CRC together with Nilay and his wonderful team!!!.
Proof-of-concept: Epigenetic reprogramming could one day be a new therapeutic path in colorectal cancer. @Nilay_Sethi explains how histone acetylation shapes CRC cell fate in this @AGA_Gastro study:
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It is awesome to have JQ-WON team to build a boat and get first place in the boat building competition at @DFCI_ChemBio retreat!!!! Awesome design, decoration, ride, and teamwork!
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It is so great to have @LilingWanLab to visit us and give a great seminar.
Had a great time visiting Dana-Farber Cancer Institute and sharing our work on chromatin mechanisms in cancer! Huge thanks to @JunQiLab for the invitation and generous hosting. So much fun reconnecting with mentor & old friends, making new ones, & a full day of amazing science!
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Congratulations to all of our friends, collaborators, and colleagues!!! @FilbinMariella @Nilay_Sethi @Oser_Lab @srviswanathan.
Dana-Farber has elected the largest cohort of physician-investigators to the 2025 class of ASCI.@DanaFarber @FilbinMariella @ManciasLab @Oser_Lab @AbbyRosenbergMD @Nilay_Sethi @srviswanathan . #ASCI #Cancer #OncoDaily #Medicine #Oncology #MedEd #MedX
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It is so exciting to receive the Curing Kids Cancer Research Award from @curingcancer together with our dearest collaborators, @ADurbinLab @RousselMartine! Thank you for supporting our work to develop a novel therapeutic strategy for medulloblastoma!
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It is great to celebrate this holiday season with a group of hardworking and self motivated lab members. Thank you for making the science so much fun. I am excited to work with you more in 2025. Happy holidays, Qi lab!!!!!
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It is also exciting to see that the Chem-Seq works so well with HDAC1/2 with @Nilay_Sethi and @LabSethi after the development on Chem-Seq of BET bromodomain @jaybradner.
Aberrations in epigenetic regulation prevent cellular differentiation and endow plasticity to cancer. By screening drugs using a new reporter system, we found that inhibiting HDAC1/2 promotes colorectal cancer (CRC) differentiation and anti-tumor activity.
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It is exciting to work with @LabSethi and whole team on this project to reveal more mechanisms on CRC differentiation.
Aberrations in epigenetic regulation prevent cellular differentiation and endow plasticity to cancer. By screening drugs using a new reporter system, we found that inhibiting HDAC1/2 promotes colorectal cancer (CRC) differentiation and anti-tumor activity.
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It is very exciting to contribute to the book: Epigenetic Drug Discovery @RoySocChem together with @ADurbinLab, Dr. Qi Liu and Aimee Qi in the lab to get it done. Thank @CherylArrowsmi1 and Dr. Ho Man Chan for the invitation. here is the link to book:
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Very happy to announce our latest paper on pediatric/AYA glioma! 🎉See tutorial from fantastic @Gavcruzeiro and @IlonLiu below 👇🏻- I’m so very proud of your resilience and dedication! #endbraincancer @DanaFarber @DFBC_PedCare @BostonChildrens.
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My team and I are so excited to get support from @StBaldricks. We look forward to bringing more chemistry to understand pediatric cancer and develop novel therapy by working together with our wonderful collaborators, @FilbinMariella @ADurbinLab @RousselMartine.
Hot off the press! 📢 Announcing our latest round of grants, totaling $9.4 MILLION for kids' #cancer research! Learn more about the projects you helped fund:
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It is exciting to see our collaborative work with Prof. Jian Zhu at OSU on KDM5A/B functions on HIV-1 published. Thank you, Jian for the wonderful collaboration. KDM5A/B contribute to HIV-1 latent infection and survival of HIV-1 infected cells - ScienceDirect.
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Congratulations, and well deserved.
So very thankful to @RecordatiD for naming me the 2024 winner of the Recordati Prize for Scientific Research. This years focus on #neuroblastoma reflects the work of many, including @JunQiLab @TheAbraLab @KStegmaier_DFCI Tom Look and many others.
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More story to follow on these two important targets.
Tweetorial alert!.Pleased to report our new paper: Here, we build on work identifying different inhibitors of the EP300/CBP histone acetyltransferases that target these proteins in different ways, to ask the question: "Does it matter where you target?".
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so excited to learn more about different domain functions in different type of cancers. It is exciting for me and my team to learn more and more about pediatric brain tumor and its dependencies. @RousselMartine @ADurbinLab @Abraham_Abrahub.
But what are the effects of targeting different domains? With support from @TheAbraLab, we tested these different inhibitors in #medulloblastoma cells. In #medulloblastoma, targeting the bromodomain of EP300/CBP caused rapid loss of a network of genes required for survival.
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It is so great to see that different cancers need EP300/CBP functions differently. The chemical probes can help us to identify the most efficient way to target EP300/CBP in different cancers, as MYCN-amplified neuroblastoma more relies on EP300 structural functions @CD_AACR.
Led by @NohaShendy, Melissa Bikowitz and Logan Sigua, and with Martine Roussel's lab, we were struck that #medulloblastoma cells seemed preferentially sensitive to @inobrodib. But inobrodib/CCS1477 didn't cross the blood-brain barrier, which limits its use in brain tumors.
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It is so exciting to see our collaborative work with @ADurbinLab @RousselMartine and Ernst Schonbrunn is now published in @NatureComms! We are so excited to learn more about the pediatric brain tumor and hopefully can find novel therapy for it.
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We are sending away our fantastic undergraduate research Paris for summer intern @ADurbinLab. Thank you for great contribution and thank Chen for great mentorship for Paris. @ADurbinLab cannot believe you stole her from us.
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