Shreyas Suryanarayana
@ShreyasMSurya
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Neuroscientist @DukeNeuro, Postdoc in the Huang lab.Interested in cortex, thalamus, motor control, development and evolution.
Durham, North Carolina
Joined May 2019
📊 Data: 🧠 36 brains imaged by whole-brain LSFM—shoutout to @LifeCanvasTech 🔬 40 brains imaged with confocal 📍Anterograde tracing from 8 isocortical areas 📍Retrograde labeling from 4 major brainstem/spinal targets 🧵 More to come—read the preprint
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We demonstrate how these two neurogenic programs—with distinct evolutionary histories—differentially shape isocortical output architecture, establishing it as the apex of hierarchical sensorimotor integration.
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This expansion is area-specific, reflecting the functional specialization of each region across motor, sensory, and associative areas, and shaped by pruning of a pan-isocortex corticospinal axonal scaffold in indirect, but not direct, ET neurons.
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Using novel genetic access to directly- and indirectly-generated extratelencephalic (ET) neurons in the same mouse, we find: 🧠 Direct ET neurons: Project primarily to forebrain & midbrain 🧠 Indirect ET neurons: Amplify these projections and massively expand to hindbrain & SpC
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Happy to share the first preprint of my postdoctoral work, where we redefine and remap the isocortical efferent projectome through two foundational neurogenic mechanisms. Done together with @anxu72317700 and collaborators @hm_mohan, and twitter-less Yongjun Qian & Shengli Zhao.
Distinct neurogenic pathways shape the diversification and mosaic organization of cortical output channels https://t.co/CIyrwqvIb2
#biorxiv_neursci
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1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the cerebral #cortex. This is the story @CellCellPress
https://t.co/R94qlCglm6 ⬇︎ thread @dev_neuro @MRC_CNDD @KingsIoPPN @KingsCollegeLon @wellcometrust
cell.com
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to...
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Happy to share this new paper from the lab in collaboration with George Augustine, characterizing synaptic connectivity between the claustrum and the anterior cingulate cortex. Congratulations to Roberto, Zach, and all co-authors! @RobertodelaTor
New in Current Biology "Presynaptic and postsynaptic determinants of claustro-cortical connectivity" CLA→ACC projections are highly specific: defined by presynaptic identity, postsynaptic target, and cortical layer. Check it here: https://t.co/8uhUAPpiQQ
#Neuroscience #Claustrum
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🎉Thrilled that the lab’s first paper is out today in @Nature! Credit to the amazing @cesca_gst, @HernyMV and @YviJohansson. Thank you to everyone involved in this massive effort!
nature.com
Nature - Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.
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Delighted that my final lead author postdoc study @HuangLabDuke is accepted in @Dev_Cell! This has been a huge challenge to publish. Big thanks to Josh for his support and shoutout to my co-authors @jessemaurica @WilliamGalbavy @borshuen
@CSHL @DukeNeuro
cell.com
Inside-out laminar patterning is a fundamental mechanism in cortical neurogenesis, but sequential specification and precise laminar deployment of projection-defined excitatory neuron types also...
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Congrats again Hemanth!!
Excited to announce that my lab will start in the Dept. of Neurobiology and Anatomy at UTHealth Houston! Will be recruiting at all levels- reach out! Learn more:
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Congrats again @DhananjayHuilg1!
We’re excited to welcome Dr. Dhananjay Huilgol to the @DBT_NBRC team as Scientist-IV! His research focuses on cellular and gene mechanisms driving neuronal differentiation and diversity, with insights into cortical evolution and neurodevelopmental disorders.
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The macrophages that pretend to be a neuron 🤣🤣🤣take a look at our study published in Nature and see how macrophage exert ms modulation of sensation and action via glutamate. Fantastic collaboration with @digiovannilab @LabPerrier
https://t.co/DQkOOZvVbF
nature.com
Nature - A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component,...
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Neuroscientists beaten at predicting experimental outcomes by LLMs trained on neuroscience studies. Who can keep up with the literature? Maybe the machines 🫨
"Large language models surpass human experts in predicting neuroscience results" w @ken_lxl and https://t.co/YOhCmQlJsu. LLMs integrate a noisy yet interrelated scientific literature to forecast outcomes. https://t.co/49WYirBdBv 1/8
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A fantastic recognition for the foundational discoveries that are reshaping the present and the future...
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”
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BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
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Really excited to share the latest preprint from my lab @CSHL. Work done by @IskoEmily, a fantastic graduate student, in collaboration with @TonyZador. So what is this paper about?
Selective expansion of motor cortical projections in the evolution of vocal novelty https://t.co/rgp8cnTtsB
#biorxiv_neursci
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Debra Silver, PhD, has been honored with the 2024 Javits Award from @NIH for her groundbreaking work on intellectual disability and autism. Her research on radial glia cells continues to illuminate the complexities of neurological disorders. @TheSilverLab
https://t.co/OaaUM7ukAj
medschool.duke.edu
Debra Silver, PhD, professor of molecular genetics and microbiology, cell biology and neurobiology at Duke University School of Medicine, has been awarded a 2024 Javits Award by the National Instit...
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A beautiful tribute to an inspirational career.......Remembering comparative neuroanatomy ‘great-grandfather’ Harvey Karten
thetransmitter.org
The National Academy of Sciences member and pioneer in studying non-mammalian vertebrate brains died on 15 July at 89 years old.
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Great place to do science, strongly recommend!!
What are the computational/neural units underlying instincts 🖥️, and where are they located in the brain 🧠? How do neural modules orchestrate behavioral modules, to generate what we semantically recognize as individual behaviors🦉? Thrilled to pursue these questions and to be
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🏆Congrats to our #LifeCanvasTravelGrant Winners for the @SfNtweets 2024 meeting. Their research using our advanced imaging tech including #SmartSPIM, #SmartBatch+, #Clear+ clearing pipeline, stood out brilliantly. @ShreyasMSurya @albit_caban and Samuel Reynolds! Stay tuned!
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