LifeCanvas Technologies
@LifeCanvasTech
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Pioneering end-to-end solutions for 3D spatial biology.
Cambridge, MA
Joined June 2018
A new @uniQure_NV study shows promise for improving AAV-based #genetherapy delivery to the CNS. The team used the LifeCanvas pipeline to visualize biodistribution throughout whole mouse brains. 🐭 🧠 Learn more & see their #SmartSPIM data: https://t.co/GoCiEeUWWL
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Happy #MicroscopyMonday! Our tools allow #neuroscience researchers like Dr. Jing Zhou (@samplease lab, @UCSF) to visualize neuronal projections with stunning detail. This video highlights the intricate wiring of cortical excitatory neurons (red) in an Emx1-Cre; Ai14 mouse brain.
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Aggrecan is a key component of perineuronal nets (PNNs), extracellular structures that surround certain neuronal sub-populations and regulate neuroplasticity. This video shows aggrecan in an intact spinal cord, processed & imaged with our pipeline. #FluorescenceFriday
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On the left: The bustling ASCN meeting hall, with Chair @DrYongXu1 and Vice-Chair @Songlaboratory visible on screen On the right: Our Senior FAS Chris Tsang with Professor Young-Jin Son at the AKN Annual Meeting
We had the opportunity to support both the American Society for Chinese Neuroscientists (ASCN) and the Association of Korean Neuroscientists (AKN). We had a wonderful time connecting with researchers at both social events over food, games, and talks!
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We had the opportunity to support both the American Society for Chinese Neuroscientists (ASCN) and the Association of Korean Neuroscientists (AKN). We had a wonderful time connecting with researchers at both social events over food, games, and talks!
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In a global effort to map #neurodevelopment across species, scientists in the BRAIN Initiative Cell Atlas Network (BICAN) used single-cell & spatial -omics approaches combined with imaging tools like #SmartSPIM to create detailed cell-type brain atlases: https://t.co/wRZxO8sNS6
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Placental hormonal regulation plays a key role in #neurodevelopment. Dr. Jacquelyn Salzbank et al. @ColumbiaMed found that reduction in the placental hormone allopregnanolone triggers sex-specific neuroinflammatory responses and microglial dysfunction: https://t.co/21E261UcSV
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Congratulations to SfN Travel Award winner Dr. @EloraMidavaine! Her poster focuses on neurobiological adaptations to chronic pain during pregnancy, using LifeCanvas whole 🧠 mapping to hone in on an endogenous opioid circuit that contributes to pregnancy-induced analgesia.
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Save room in your #SfN25 itinerary for some more 3D 🧠 data exploring research areas from brain development to neuroimmune pathways! Next week's poster lineup features presentations from Drs. @ingvildeb, @EloraMidavaine, Quan Jiang, @ZhennWang, & Yidan Chen.
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This weekend kicks off #SfN25! Have you made your poster game plan yet? Today and tomorrow we'll be sharing a selection of posters featuring LifeCanvas 3D histology and imaging data 🧠 that you can add to your agenda. Check out our Sunday schedule below.
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In a new Nature study, Dr. @gabriel_neiman et al. developed an in vitro screening method to predict transfection efficacy of LNP-mRNA complexes in the heart, validating it with #SmartSPIM imaging in whole mouse hearts. Check out the paper: https://t.co/cBnNYqn3vK
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We recently went down to New Orleans to visit @TulaneBrain and demonstrate #tissueclearing techniques for neuroscientists. Thanks Dr. Deniz Ucar for hosting us at the Cell and Tissue Imaging Core!
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📣📣 We've extended our travel award deadline to Tues, Nov 11th. A few more days left to apply for $1000 towards #SfN25 travel expenses! Just tell us how you used LifeCanvas tech in your poster. Winner announced next Friday, 11/14!
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Glomeruli, the filtering parts of nephrons, are visible in cyan in this mouse kidney section imaged with #DALISPIM. Our new open-top #lightsheet microscope's unique design allowed us to image this 1-mm thick sample directly in a 12-well plate. #nephrology
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"I have too many cool 3D microscopy images in my algorithm" - no one Connect with us on Bluesky and Instagram to bring some ✨fluorescence✨ into your daily scroll: BSky: https://t.co/FA73m7nN8g IG: https://t.co/qeh5ElKrQO
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Check out the paper:
cell.com
Mohammed et al. developed ingestible capsules that sample the microbiome of the upper gastrointestinal tract utilizing a purely passive and autonomous sampling mechanism. Our capsules, which have...
Dr. @kramadi's lab at NYU Abu Dhabi used the LifeCanvas pipeline to develop CORAL, an ingestible device to non-invasively sample the small intestine #microbiome. The #SmartSPIM video below shows blood vessels (pink) & epithelial cells (blue) in rat duodenum.
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Dr. @kramadi's lab at NYU Abu Dhabi used the LifeCanvas pipeline to develop CORAL, an ingestible device to non-invasively sample the small intestine #microbiome. The #SmartSPIM video below shows blood vessels (pink) & epithelial cells (blue) in rat duodenum.
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For the first time, we show the spatial heterogeneity of mast cell-nociceptive sensory neuron clusters across the lumen-surface axis of bladder.
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