Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: https://t.co/GOE3GZlaLL For more information on vaccines in pregnancy visit https://t.co/ZT6ZSXxkjl

New paper from Julie Jézéquel and the @Rico_lab on role of cadherins in neuronal inhibition out now in @NatureComms! https://t.co/i7bxUZG80a

7/10 For PV interneurons, Vgf is the critical gene modulating the plasticity of inhibitory inputs received from other PV interneurons

10/10 Here’s the paper @Nature if you want to dig in https://t.co/HvYAZe9LZc That’s it. Thanks for sharing! @dev_neuro @MRC_CNDD @KingsIoPPN @ERC_Research

3/10 Neuronal activity operates within a tightly controlled range for the optimal functioning of #brain circuits. When synaptic connectivity and network activity are modified, such as when we are learning, compensatory mechanisms are needed to maintain stability

9/10 In sum, our findings identify a previously unknown form of interneuron plasticity and strengthen the idea that neuropeptide signalling plays crucial roles in maintaining neural circuit stability. Funded by the magnificents @ERC_Research and @RosetreesT

5/10 How is this achieved? We found that PV interneurons induce the expression of two genes encoding multiple neuropeptides, Scg2 and Vgf, in response to increased activity

4/10 Using experimental manipulations, we found that PV interneurons scale the inhibition they receive to maintain stability. When the activity of a PV interneuron increases, it “requests” more inhibitory inputs from other PV+ interneurons, effectively rebalancing its activity

2/10 The cortex contains two main classes of neurons: excitatory “go” pyramidal cells and inhibitory “no-go” #interneurons

1/10 Our latest research, led by @MartijnSelten, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @Nature https://t.co/HvYAZe9LZc 🧵⬇︎ @dev_neuro @MRC_CNDD @KingsIoPPN @ERC_Research @RosetreesT

We invite you to our inaugural lecture for Professor @RobertHindges called 'With an eye on the brain' 📅When? 3 December 2024 17.30-18.30 📍Where? Lecture Theatre 1, New Hunt's House, Guy's Campus Register at this link: https://t.co/2ItGfc3wIv #Neuroscience

Apply now! Fully @The_MRC funded #PhD fellowships with enhanced stipend in #neuroscience #neurodevelopmental disorders, @MRC_CNDD. Deadline Jan 1st 2025! https://t.co/onar7oAmMB Home students only I'm afraid. Please RT!

Exciting and stimulating couple of days discussing how to bridge the gap in neurodevelopmental conditions. Huge thanks to all our speakers, organisers, and everyone who attended. #D2T24

Please come along to our next External Seminar, this Thursday at 1pm. We will hear from @EBaBlab @BristolUni, hosted by @LabDarren See you there!

Last few tickets remaining!

Fully funded iCASE PhD with @laupellegrini and @VernonLab_KCL to investigate psychedelic drug exposure in human choroid plexus & CSF using organoids. Apply by 29 Oct: https://t.co/QZyRqlhtgS #MRCDTP25 #PhDOpportunity #Neuroscience #MentalHealthResearch #Organoids #Psychedelics

Registration now open for our next symposium! 🧠 From Discovery to Translation: Bridging the Gap in Neurodevelopmental Conditions 📅 18-19 Nov 2024 Organised by @JonnyOMuir @Joel_Winston @laupellegrini Alice Egerton & Laura Mantoan Tickets limited!

To continue our External Seminar series, this week we welcome Dr Manual Valiente @valientelab 🗓️ 1pm, Thursday 26 September 2024 📍 Lecture Theatre 2, New Hunt’s House, Guy’s Campus #metastasis #tumour #brain #neuroscience @MRC_CNDD @cniostopcancer @renacer_brainmetnetwork

🚨 Deadline is approaching fast— 25th Sept! ⏳ There’s still time to get your application in and join us... 📄✨

We are looking forward to seeing @Sergiu_P_Pasca work. Please be aware that it is 1 pm (not 2 pm) at Lecture Theatre 1