M Stephenson-Jones
@StephensonJones
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Neuroscientist investigating the Neurobiology of Reinforcement Learning. Group leader @SWC_Neuro.
Sainsbury Wellcome Centre, UCL, London
Joined July 2017
đThrilled that the labâs first paper is out today in @Nature! Credit to the amazing @cesca_gst, @HernyMV and @YviJohansson. Thank you to everyone involved in this massive effort!
nature.com
Nature - Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable soundâaction associations in the tail of the striatum.
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Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics. New preprint w/@AntjeKilias @bartos_marlene @JF_Sauer showing that representational drift isnât random https://t.co/ESfIQwAIGt
biorxiv.org
The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable...
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âWhere was I again?â Our study published today https://t.co/SssPQUDv7l reveals brain cells can form a coordinate system for our behaviours. Instead of locating where we are in the world, this coordinate system tells us âwhere we areâ in a sequence of behaviours: đ§”below:
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Two new postdoc positions available at UCL's Institute of Behavioural Neuroscience, with job adverts to be posted shortly. Feel free to DM if interested...
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Shelter experience boosts #dopamine release in the nucleus accumbens, generating a goal-location memory. Reactivating a neuronal ensemble developed from shelter experience enables navigation to the goal during escape. @Hyungbae_Kwon @KanghoonJung
https://t.co/b7L2kDpjls
nature.com
Nature Neuroscience - Jung et al. show that shelter experience boosts dopamine release in the nucleus accumbens, generating a goal-location memory. Reactivating a neuronal ensemble developed from...
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Super fun - watch in real time as contents are moved from one working memory slot to another :)
science.org
How the brain mentally sorts a series of items in a specific order within working memory (WM) remains largely unknown. We investigated mental sorting using high-throughput electrophysiological...
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come and join our team in Spain! we are looking for a researcher with a quantitative background to study the neurocompulational logic underlying visual attention-distractor networks
The lab led by @KardamakisAndre is seeking a researcher to explore the neurocomputational mechanisms of biological visual attention and distractor networks at the @NeuroAlc Open to candidates with an MSc, PhD, or equivalent experience. More info đ https://t.co/wJ8Z3eS9HD
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We are looking for postdocs funded by an ERC starting grant to investigate the mechanisms of cortical predictive learning! Opportunities to use in vivo whole cell recordings, 2-photon imaging VR for mice, and more. Please reach out if you are interested!
elxw.fa.em3.oraclecloud.com
We are looking for a motivated postdoctoral researcher to conduct basic research into sensorimotor plasticity in the visual cortex of mice, by utilizing virtual reality systems alongside in vivo...
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Neuroscience Faculty Job @UniofOxford Our department is searching widely to fill TWO neuroscience professorships (tenured or on track). Deadline : 18th of Nov. Further info: https://t.co/l3affUQBYm Apply and join our community. Any question drop me a line.
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Cool new evidence of the importance of representations outside of SWRs mPFC neurons that *aren't* modulated by SWRs are more spatially tuned and directionally selective, and mPFC has non-local representations of the upcoming choice independent of SWRs https://t.co/0dGEI11Fto
biorxiv.org
The hippocampus is known to encode spatial information and reactivate experienced trajectories during sharp-wave ripple events. These events are thought to be key time-points at which information...
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What is the nature of sensory prediction error signals in the neocortex? Our research published in @Nature reveals that these error signals are amplified responses to unexpected inputs, mediated by a cooperative thalamocortical circuit mechanism! 1/4 https://t.co/fS9ztjB1St
nature.com
Nature - Experiments in mice show that a cortico-thalamic circuit generates prediction-error signals in primary visual cortex that amplify visual input that deviates from animalsâ expectations.
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Where in the brain is abstract map generated? It is the lateral entorhinal cortex (LEC) and the medial prefrontal cortex (mPFC), working together!! Here is our new finding published in @Nature Prefrontal and lateral entorhinal neurons co-dependently learn itemâoutcome rules
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For fun holiday reading: what is the role of neocortex? The amazing @SaraMederos_ shows that a specific corticofugal pathway is crucial for learning to overwrite instinctive reactions. An epic study going from neural pathway down to synaptic mechanism!
biorxiv.org
Fast instinctive responses to environmental stimuli can be crucial for survival, but are not always optimal. Based on prior experience, animals can thus adapt their behavior and suppress instinctive...
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Are we too cortex exclusive? đ§ We found that perceptual decisions depend on a cortical pathway through thalamus (transthalamic), even though corticocortical projections are intact. Transthalamic pathways thus play a major but underappreciated role in perception. 1/5
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This work was a collaboration between scientists at @SWC_Neuro and @GatsbyUCL Thanks for reading! đ 13/13
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If you are interested in these questions and want to follow up on this work get in touch! We have multiple fully funded PhD and Postdoc positions available to work on this. 12/13
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This raises many questions, what is the source of replay if itâs not the hippocampus? How is replay in the different memory systems coordinated? Is striatal replay and dopamine release synchronized? 11/13
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This suggests that replay is a common feature for memory consolidation but that the hippocampus is not! 10/13
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In fact, not a single feature of the replay changed following the lesion. 9/13
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