Exciting work from @MarinLab in @CellCellPress, revealing a mechanism regulating the development of parvalbumin (PV) interneurons. Their study uncovers a postnatal molecular switch driving the activity-dependent maturation of these cells in the cortex.

10/10 Here’s the paper @CellCellPress if you want to dig in https://t.co/R94qlCglm6 That’s it. Thanks for sharing! @dev_neuro @MRC_CNDD @KingsIoPPN @wellcometrust

9/10 In sum, our findings reveal a postnatal molecular switch that drives the activity-dependent maturation of parvalbumin interneurons, a critical population for cortical function. Funded by the @wellcometrust

8/10 Importantly, this mechanism also allows PV interneurons to regulate their mitochondrial content and function, which may also contribute to their maturation

7/10 PGC-1alpha cooperates with ERR-gamma to directly regulate the transcription of many PV-enriched genes. Incidentally, it also seems involved in repressing genes that are typically enriched in other cells, like SST interneurons

6/10 How is this achieved? We discovered that PGC-1alpha regulates the expression of most genes that are typically enriched in mature PV interneurons

5/10 What are the mechanisms regulating the protracted maturation of cortical interneurons? We found that this process requires neuronal activity and is mediated by the transcriptional modulator PGC-1alpha

4/10 Interestingly, while PV interneurons are generated in the embryo, they are late bloomers: in humans, for example, it takes more than two years for PV interneurons to acquire their mature properties

3/10 Several unique properties distinguish PV interneurons: They exert a very tight control over the output of pyramidal cells; are fast-spiking, meaning they can fire action potentials at very high frequencies; are covered by perineuronal nets, and have many mitochondria

2/10 PV interneurons are a type of inhibitory neuron in the cortex, characterized by their expression of the calcium-binding protein parvalbumin. These neurons play a crucial role in regulating neuronal activity and are involved in memory, sensory processing, and motor control.

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the cerebral #cortex. This is the story @CellCellPress https://t.co/R94qlCglm6 ⬇︎ thread @dev_neuro @MRC_CNDD @KingsIoPPN @KingsCollegeLon @wellcometrust

I am excited to announce that the Ciceri lab will open its doors in September 2025 at the San Raffaele Telethon Institute for Gene Therapy, SR-TIGET! @SanRaffaeleMI @Fondaz_Telethon

We're #hiring! Looking for an experienced and dynamic Research Strategy Manager... More details in link below Deadline 09 July https://t.co/ymHwYZxrqg

La enfermedad metastásica: cada vez más cerca de una cura o de poder evitarla. Nuestros premiados, el Dr. Eduard Batlle, jefe de @BatlleLab en @IRBBarcelona, y el Dr. Óscar Marín, jefe de @MarinLab en @KingsCollegeLon, ambos premiados en ediciones anteriores y actuales miembros

Our study on the impact of altered serotonin (5-HT) signalling on developing sensory cortex is now live @NatureComms We use longitudinal in vivo imaging of 5-HT & neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction.

#Neurociencia | 🧠 El neurocientífico @Marinlab, del @KingsCollegeLon, explica las posibles intervenciones del #cerebro en desarrollo para acotar trastornos del neurodesarrollo. ✍ @alilo1920 https://t.co/nX0OoFQZQn

#Neurociencia | 🧠 El neurocientífico @Marinlab, del @KingsCollegeLon, explica las posibles intervenciones del #cerebro en desarrollo para acotar trastornos del neurodesarrollo. ✍ @alilo1920 https://t.co/oBEeATlHWw

JUST PUBLISHED Development of GABAergic Interneurons in the Human Cerebral Cortex Oscar Marín @MarinLab of @KingsCollegeLon @FENSorg @WileyNeuro #Gaba #Neurons https://t.co/kTrLNMv5nD

1/12. How do cortical interneurons select specific pyramidal cells during development? Julie Jezequel in @Rico_lab has identified specific cellular and molecular codes that interneurons use to target pyramidal cell types @NatureComms @dev_neuro @MRC_CNDD @KingsIoPPN

OUT NOW in @EJNeuroscience Development of GABAergic Interneurons in the Human Cerebral Cortex Oscar Marín @MarinLab of @KingsCollegeLon @FENSorg @WileyNeuro #Gaba #Neurons https://t.co/KyyMjpr74v