Our new paper from the @FrydmanLab published in @ScienceMagazine identifies 22 TRiC mutations in patients with brain disorders of unknown origin. We characterized these disease-linked mutations in 3 model species and found them to be dominant mutations. https://t.co/iBjut6QRyZ

I’ve been awarded an @alzassociation grant for my research that combines a multimodal approach to understanding the brain’s molecular pathological changes in aging and AD. Thanks to Carlo Condello, @JayShin, Nakabeppu, and Kubo Sensei for their support and mentorship. #ALZFunded

7/ Find more in the link: https://t.co/iGBhRra75p. We look forward to engaging with the scientific community for feedback and discussions. #Spatialtranscriptomics #Bioinformatics #Brainaging #BioRxiv #Schizophrenia #Neuroscience #molecularneuroanatomy

6/Huge thanks to our incredible multidisciplinary team @SatoshiYoshina1, @JayShin, @chungchau_hon, @carninci , Kubo-sensei and others.

5/We show that ILAs play a crucial role in the disrupted brain circuitry of schizophrenia and propose potential targets for novel therapies and morphological markers for histopathological diagnosis.

4/We also found a negative relationship between ILA processes and GFAP+ cell density in the grey matter with "healthy" aging.

3/ Further histological investigations showed that interlaminar astrocytes (ILA) in layer 1, which extend long processes into cortical layers, exhibited reduced cell density and abundance of processes in schizophrenia.

2/ We performed an integrative analysis of spatial and single-nucleus transcriptomics of the anterior cingulate cortex in schizophrenia patients, together with a thorough histological analysis. Our findings highlight significant alterations in glial cells, primarily astrocytes.

1/ I am happy to share that our latest research paper is now available as a preprint on bioRxiv! 🧠🧬Integrative Transcriptomics Reveals Layer 1 Astrocytes Altered in Schizophrenia https://t.co/iGBhRra75p

Massive effort, honored to be part of it !

Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful

Single-nucleotide variant calling in single-cell sequencing data with Monopogen | Nature Biotechnology

Scientific discussion and brainstorming session to push our ideas and improve our research. Good times with @SCIJulioLeon and @JARamilowski.

When you leave but never really leave ;)Schizophrenia research 🎯 Excited to contribute to understanding this complex disorder. #JikeiUniversity #spatialtranscriptomics #Japanbrainbank

We are excited to release Seurat v5- with new methods for multimodal, spatially resolved, and massively scalable single-cell analysis. https://t.co/7BMGF7x1wV

⭐️Cellular foundation for a new perspective of AD pathophysiology⭐️ 👉Cellular dynamics across aged human brains uncover a multicellular cascade leading to Alzheimer's disease https://t.co/UsFbBY9gOs Outstanding work from @naomi_habib and Philip L. De Jager labs!👏👏

Jackson Pollock or spatial profiling? A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain https://t.co/yHVP8cjrGO Preprint @AllenInstitute of whole mouse brain atlas, comprised of >11 million single cells profiled with scRNA seq & MERFISH 🤯

Delighted to share our paper in @stemcellreports on a novel 3D #iPSC-derived model of GRN- #FTD with a focus on astroglia toxicity. Fantastic collaboration with @UllianLab HuangLab @KampmannLab @synapticure @AlectorTx and others. #ALS #Organoids #TDP43 https://t.co/TrW58uCx8r

Meet my 94-year-old grand uncle in rural Peru, with some mobility problems but cognitively sharp, making jokes, and telling me about all the other relatives I need to visit, especially my other tio-Abuelo, who turned 100 last year. Tempted to take some blood samples #healthyaging

Last experiment in Japan before going back to CA, #spatialtranscriptomics #NasuHakola disease!