Manolis Kellis
@manoliskellis
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Dissecting disease mechanism. Single-cell, Epigenomics, Regulatory Genomics, Disease Genetics, Brain, Cancer, Metabolism. @MIT Prof, @MIT_CSAIL, @BroadInstitute
Cambridge, MA
Joined July 2009
Kellis Lab is hiring! New grants in #Alzheimers #Schizophrenia #Cancer #EHR #SingleCell #Genome #Epigenome #Transcription #Disease integration. Computational & experimental positions, profiling and circuitry dissection. Join us! @MIT_CSAIL @BroadInstitute
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Excited to share our latest preprint by Alexis Yang and Gary Lee, in collab with the @jberchuck lab: https://t.co/cb3pRjketO. We found that transcription of enhancers (a mark of activation) causes distinct fragmentation patterns in #cfDNA.
biorxiv.org
Circulating cell-free DNA (cfDNA) assays are being widely adopted in oncology and maternal-fetal medicine. Patterns of cfDNA fragmentation can provide useful information about gene regulation and...
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So proud of #RileyMangan and #NikithaThoduguli presenting platform talks at #ASHG25 today on #SingleCell phenotypes for #Alzheimers, and #DeepLearning #Evolution of human cis-regulatory elements. Spread the word! @MIT @BroadInstitute @HarvardMed
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This holiday, skip the stress. USDA Prime steaks delivered to their door. They'll thank you later. 8 FREE Steak Burgers + FREE shipping ($145 value) on orders $149+ Use code SANTA149 →
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MIT Course announcement: Machine Learning for Computational Biology #MLCB25 Fall'24 Lecture Videos: https://t.co/Puzq59oni4 Fall'24 Lecture Notes: https://t.co/RRNRY1SZaZ (a) Genomes: Statistical genomics, gene regulation, genome language models, chromatin structure, 3D genome
Today was my last lecture for @MIT #ComputationalBiology: #Genomes, #Networks, #Evolution, #Health. I recorded each and immediately posted online here: https://t.co/z7eouWlosl Please do share, and let me know which topics need more explanations, clarifications, and corrections!
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Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma @NatureComms @gmboland @manoliskellis
https://t.co/ZaxZGRtcVm
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MIT Course announcement: Machine Learning for Computational Biology #MLCB25 Fall'24 Lecture Videos: https://t.co/Puzq59oni4 Fall'24 Lecture Notes: https://t.co/RRNRY1SZaZ (a) Genomes: Statistical genomics, gene regulation, genome language models, chromatin structure, 3D genome
Today was my last lecture for @MIT #ComputationalBiology: #Genomes, #Networks, #Evolution, #Health. I recorded each and immediately posted online here: https://t.co/z7eouWlosl Please do share, and let me know which topics need more explanations, clarifications, and corrections!
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I could never imagine combining deep conversations on #AI & #longevity with the beauty of my beloved Andros… until the AI Longevity Salon, hosted by @manoliskellis - where science met philosophy & ideas on longevity flowed. Thanks, Manolis, for the photos & the inspiring event.
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Excellent talk by @manoliskellis at Athens College on AI and navigating complex data with Mantis. https://t.co/WvcQUwAq8S
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If you are at ICML2025, welcome to attend our workshop "Multi-modal Foundation Models and Large Language Models for Life Sciences" tomorrow (Jul 19 Saturday). The workshop features a stellar lineup of invited speakers, including Valentina Boeva @val_boeva, Manolis Kellis
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Greek friends, join us next Sunday July 6 in @Athens, as we hack the Future of #AI in the Cradle of Western Civilization, at the #EugenidesFoundation. After the success of our last hack at MIT, we're partnering with SundAI Club again to bring cutting-edge technologies to the
If you love #Hacking and building the future of #AI, join us next Sunday May 18 for a joint #Hackathon with @Sundai_club (Boston), and Æthos (Berlin). You can be one of the first to build on our #Mantis Cognitive Cartography Platform for Human-driven AI-powered Visual Data
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So excited to speak on #AI powered #DrugDiscovery at 10am this morning, at the @MIT Club of Boston @MITboston BioSummit on AI in HealthCare and Biotech. *Live now on Zoom*: https://t.co/LqPOX6lgPp Already 140 attendees and growing, please join us! @MIT_alumni @MITBiology @MITEECS
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If you love #Hacking and building the future of #AI, join us next Sunday May 18 for a joint #Hackathon with @Sundai_club (Boston), and Æthos (Berlin). You can be one of the first to build on our #Mantis Cognitive Cartography Platform for Human-driven AI-powered Visual Data
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Please join us for an @MITBiotechGroup and @MITEECS and @IEEEorg @TheACMG joint mixer tonight, at the interface of #ComputerScience and #Biology. Mixer from 6pm-7pm, and panel conversation from 7pm-8pm, in the @MIT #StataCenter student street, room 32-144. Excited to many of
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.@MIT_CSAIL Prof. @manoliskellis is reimagining healthcare with AI: from one-size-fits-all drugs to precision, modular treatments tailored to each patient’s biology. His lab is mapping disease at the molecular level to revolutionize drug discovery. More: https://t.co/aCXvRNBYmi
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This episode explores former Marine Emory Wongor's transformational journey walking the entire Pacific Crest Trail. He discusses combat experiences, meditation parallels, humor as a coping mechanism, the “post-trail blues”
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Beautiful work by @KrithikTweets, @PardisSabeti, @Sameed, @_albertgu and team at @BroadInstitute @MIT @Harvard! Dramatic improvements in modeling and speed. AI for Biology and Medicine is continuing its amazing acceleration
🧬 Meet Lyra, a new paradigm for accessible, powerful modeling of biological sequences. Lyra is a lightweight SSM achieving SOTA performance across DNA, RNA, and protein tasks—yet up to 120,000x smaller than foundation models (ESM, Evo). Bonus: you can train it on your Mac. read
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Excited to share our salon conversation on the Neuronal Basis of Consciousness with @KennethSKosik and #EmeryBrown. https://t.co/l21sYf4FY5 Eager to hear your thoughts and comments, and also suggestions about future salon speakers, topics, and guests! @HarvardMed @BroadInstitute
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